2. Gene
  3. FOXR1 - forkhead box R1 Gene

FOXR1 - forkhead box R1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：叉头盒 R1

种属: Homo sapiens

同用名: FOXN5; DLNB13

基因 ID: 283150 | 基因类型: protein coding

关于 FOXR1

Cytogenetic location: 11q23.3 Genomic coordinates (GRCh38): 11:118,971,761-118,981,287 (from NCBI)

This gene has 3 transcripts (splice variants), 1 gene allele, 82 orthologues, 42 paralogues and is associated with 42 phenotypes. Restricted expression toward testis (RPKM 1.2).

功能概要

该基因编码叉头框 (FOX) 转录因子家族的成员。 FOX 家族成员是单体的螺旋-转角-螺旋蛋白，具有大约 110 个氨基酸的核心 DNA 结合域。许多 FOX 转录因子在早期发育过程中决定细胞命运。这种叉头盒蛋白缺少在许多其他 FOX 家族成员中发现的 C 末端碱性区域。它位于神经母细胞瘤中通常缺失的 11q23.3 区域内。[RefSeq 提供，2008 年 7 月]

This gene encodes a member of the forkhead box (FOX) family of transcription factors. FOX family members are monomeric, helix-turn-helix proteins with a core DNA-binding domain of approximately 110 aa. Many FOX transcription factors play roles in determining cell fates during early development. This forkhead box protein lacks the C-terminal basic region found in many other FOX family members. It is located within the 11q23.3 region which is commonly deleted in neuroblastomas. [provided by RefSeq, Jul 2008]

FOXR1 基因产物(1)

mRNA Protein Name
NM_181721.3 NP_859072.1 forkhead box protein R1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: 通过直接分析推断
34723967 GOA
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
IDA: 通过直接分析推断
34723967 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
25416956 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
34723967 GOA
involved in regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
34723967 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
34723967 GOA
located in nucleus IDA
IDA: 通过直接分析推断
34723967 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

FOXR1 蛋白结构

Forkhead

Forkhead: Forkhead domain (173 - 265)

  • 0
  • 100
  • 200
  • 292 a.a.
蛋白主名 其他名称

forkhead box protein R1

forkhead box protein N5

FOXR1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra FOXR1 Q6PIV2 FLJ13057 Homo sapiens Q53SE7
Validated Y2H
25416956
Intra FOXR1 Q6PIV2 FLJ13057 Homo sapiens Q53SE7
Y2H Prey Pooling
25416956
Intra FOXR1 Q6PIV2 FLJ13057 Homo sapiens Q53SE7
Y2H Array
25416956
Intra FOXR1 Q6PIV2 DNM2 Homo sapiens P50570-2
Validated Y2H
32814053
Intra FOXR1 Q6PIV2 DNM2 Homo sapiens P50570-2
Y2H Array
32814053
Intra FOXR1 Q6PIV2 DNM2 Homo sapiens P50570-2
Y2H Pooling
32814053
Intra FOXR1 Q6PIV2 DMWD Homo sapiens G5E9A7
Validated Y2H
32814053
Intra FOXR1 Q6PIV2 DMWD Homo sapiens G5E9A7
Y2H Array
32814053
Intra FOXR1 Q6PIV2 DMWD Homo sapiens G5E9A7
Y2H Pooling
32814053
Intra FOXR1 Q6PIV2 BANP Homo sapiens Q8N9N5-2
Validated Y2H
32296183
Intra FOXR1 Q6PIV2 BANP Homo sapiens Q8N9N5-2
Y2H Array
32296183
Intra FOXR1 Q6PIV2 BANP Homo sapiens Q8N9N5-2
Y2H Prey Pooling
32296183
Intra FOXR1 Q6PIV2 MECP2 Homo sapiens P51608
Validated Y2H
32814053
Intra FOXR1 Q6PIV2 MECP2 Homo sapiens P51608
Y2H Array
32814053
Intra FOXR1 Q6PIV2 MECP2 Homo sapiens P51608
Y2H Pooling
32814053
Intra FOXR1 Q6PIV2 APBB2 Homo sapiens Q92870-2
Y2H Array
32814053
Intra FOXR1 Q6PIV2 APBB2 Homo sapiens Q92870-2
Validated Y2H
32814053
Intra FOXR1 Q6PIV2 APBB2 Homo sapiens Q92870-2
Y2H Pooling
32814053
Intra FOXR1 Q6PIV2 GMCL1 Homo sapiens Q96IK5
Validated Y2H
32296183
Intra FOXR1 Q6PIV2 GMCL1 Homo sapiens Q96IK5
Y2H Array
32296183
Intra FOXR1 Q6PIV2 GMCL1 Homo sapiens Q96IK5
Y2H Prey Pooling
32296183
Intra FOXR1 Q6PIV2 TOR1A Homo sapiens O14656-2
Y2H Pooling
32814053
Intra FOXR1 Q6PIV2 TOR1A Homo sapiens O14656-2
Validated Y2H
32814053
Intra FOXR1 Q6PIV2 TOR1A Homo sapiens O14656-2
Y2H Array
32814053
Intra FOXR1 Q6PIV2 SMN1 Homo sapiens Q16637
Validated Y2H
32814053
Intra FOXR1 Q6PIV2 SMN1 Homo sapiens Q16637
Y2H Pooling
32814053
Intra FOXR1 Q6PIV2 SMN1 Homo sapiens Q16637
Y2H Array
32814053
Intra FOXR1 Q6PIV2 PMP22 Homo sapiens A0A6Q8PF08
Y2H Array
32814053
Intra FOXR1 Q6PIV2 PMP22 Homo sapiens A0A6Q8PF08
Y2H Pooling
32814053
Intra FOXR1 Q6PIV2 PMP22 Homo sapiens A0A6Q8PF08
Validated Y2H
32814053
Intra FOXR1 Q6PIV2 A2M Homo sapiens P01023
Validated Y2H
32814053
Intra FOXR1 Q6PIV2 A2M Homo sapiens P01023
Y2H Array
32814053
Intra FOXR1 Q6PIV2 A2M Homo sapiens P01023
Y2H Pooling
32814053
Intra FOXR1 Q6PIV2 DPPA4 Homo sapiens Q7L190
Y2H Prey Pooling
32296183
Intra FOXR1 Q6PIV2 DPPA4 Homo sapiens Q7L190
Validated Y2H
32296183
Intra FOXR1 Q6PIV2 DPPA4 Homo sapiens Q7L190
Y2H Array
32296183
Intra FOXR1 Q6PIV2 PPCDC Homo sapiens Q96CD2
Validated Y2H
32296183
Intra FOXR1 Q6PIV2 PPCDC Homo sapiens Q96CD2
Y2H Prey Pooling
32296183
Intra FOXR1 Q6PIV2 PPCDC Homo sapiens Q96CD2
Y2H Array
25416956
Intra FOXR1 Q6PIV2 PPCDC Homo sapiens Q96CD2
Y2H Array
32296183
Intra FOXR1 Q6PIV2 CEP19 Homo sapiens Q96LK0
Validated Y2H
32296183
Intra FOXR1 Q6PIV2 BANP Homo sapiens Q8N9N5
Y2H Prey Pooling
25416956
Intra FOXR1 Q6PIV2 MEOX2 Homo sapiens P50222
Y2H Prey Pooling
25416956
Intra FOXR1 Q6PIV2 MEOX2 Homo sapiens P50222
Validated Y2H
25416956
Intra FOXR1 Q6PIV2 MEOX2 Homo sapiens P50222
Y2H Array
25416956
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Cns Neuroblastoma With Foxr2 Activation

Central Nervous System Neuroblastoma With Foxr2 Activation

Cns Nb-Foxr2

Cns Neuroblastoma, Foxr2-Activated
Central Nervous System Neuroblastoma
Central Nervous System Germ Cell Tumor

Central Nervous System Germ Cell Tumour

Germ Cell Tumor Of The Cns

Germ Cell Tumour Of The Cns
Lymphedema-Distichiasis Syndrome

Lymphedema With Distichiasis

Lymphedema-Distichiasis Syndrome With Renal Disease And Diabetes Mellitus

LPHDST

Distichiasis-Lymphedema Syndrome

Lymphedema Distichiasis Syndrome

Hereditary Lymphedema-Distichiasis Syndrome

Lymphedema Distichiasis
Hematologic Cancer

Hematologic Neoplasm

Hematologic Neoplasms

Hematologic Malignancies

Blood Cancer

Hematologic Malignancy

Hematological Tumors

Hematopoietic And Lymphoid System Tumor

Hematopoietic Cancer

Hematopoietic Neoplasm

Hematopoietic Tumors

Malignant Hematopoietic Neoplasm

Liquid Tumor

Hematopoietic Neoplasms
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS05078 FOXR1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris FOXR1 VGNC VGNC:40969
Rattus norvegicus FOXR1 RGD RGD:1309739
Macaca mulatta FOXR1 VGNC VGNC:107449
Bos taurus FOXR1 VGNC VGNC:29104
Felis catus FOXR1 VGNC VGNC:62347
Mus musculus FOXR1 MGD MGI:2685961
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