PRNP/CD230 蛋白, Human (HEK293, Fc)

Although its primary function is unknown, the PRNP/CD230 protein has been implicated in multiple neuronal processes, including neuronal development, synaptic plasticity, and myelin homeostasis. PRNP acts as an agonist of the ADGRG6 receptor and promotes the maintenance of myelin. PRNP/CD230 Protein, Human (HEK293, Fc) is the recombinant human-derived PRNP/CD230 protein, expressed by HEK293 , with C-hFc labeled tag.

PRNP/CD230 虽然其主要生理功能尚不清楚，但与各种神经元过程有关，包括神经元发育和突触可塑性。此外，它可能通过充当 ADGRG6 受体的激动剂，在维持神经元髓鞘和促进髓鞘稳态方面发挥至关重要的作用。该蛋白质参与铁吸收和体内平衡进一步强调了其多方面的功能。PRNP 的可溶性寡聚物对神经母细胞瘤细胞表现出毒性，在体外诱导细胞凋亡。在硫酸乙酰肝素链的促进下，与 GPC1 的结合将 PRNP 靶向脂筏，并有助于抗坏血酸介导的 GPC1 脱氨酶降解其硫酸乙酰肝素侧链的 Cu(2+) 或 Zn(2+) 可用性。PRNP 以单体和同二聚体形式存在，具有聚集成淀粉样原纤维的倾向，可能受到铜结合的影响。值得注意的是，PRNP 与多种蛋白质相互作用，包括 GRB2、APP、ERI3/PRNPIP、SYN1 和 ADGRG6，表明分子相互作用的复杂网络。

Human

HEK293

C-hFc

P04156/NP_000302.1 (K23-G229)

5621  [NCBI]

Approximately 57.4 kDa

Greater than 90% as determined by reducing SDS-PAGE

溶液

Supplied as a 0.2 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

N/A.

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.