1. Gene
  2. PRNP - prion protein Gene

PRNP - prion protein Gene

中文名称:朊蛋白

种属: Homo sapiens

同用名: CJD; GSS; PrP; ASCR; KURU; PRIP; PrPc; CD230; AltPrP; p27-30; PrP27-30; PrP33-35C

基因 ID: 5621 | 基因类型: protein coding

关于 PRNP

Cytogenetic location: 20p13 Genomic coordinates (GRCh38): 20:4,686,456-4,701,588 (from NCBI)

This gene has 4 transcripts (splice variants), 118 orthologues and is associated with 13 phenotypes. Ubiquitous expression in brain (RPKM 148.7), ovary (RPKM 52.6) and 24 other tissues.

功能概要

该基因编码的蛋白质是一种膜糖基磷脂酰肌醇锚定糖蛋白,倾向于聚集成棒状结构。编码的蛋白质包含五个串联八肽重复的高度不稳定区域。该基因位于 20 号染色体上,位于一个基因上游约 20 kbp 处,该基因编码一种与该基因编码的蛋白质在生化和结构上相似的蛋白质。重复区域以及该基因其他地方的突变与克雅氏病、致死性家族性失眠症、格斯特曼-施特劳斯勒病、亨廷顿病样 1 和库鲁病有关。已发现该基因的重叠开放阅读框,该基因编码较小的、结构无关的蛋白质 AltPrp。可变剪接导致多个转录本变体。[RefSeq 提供,2014 年 11 月]

The protein encoded by this gene is a membrane glycosylphosphatidylinositol-anchored glycoprotein that tends to aggregate into rod-like structures. The encoded protein contains a highly unstable region of five tandem octapeptide repeats. This gene is found on chromosome 20, approximately 20 kbp upstream of a gene which encodes a biochemically and structurally similar protein to the one encoded by this gene. Mutations in the repeat region as well as elsewhere in this gene have been associated with Creutzfeldt-Jakob disease, fatal familial insomnia, Gerstmann-Straussler disease, Huntington disease-like 1, and kuru. An overlapping open reading frame has been found for this gene that encodes a smaller, structurally unrelated protein, AltPrp. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]

PRNP 基因产物(12)

mRNA Protein Name
NM_000311.5 NP_000302.1 major prion protein preproprotein Prp precursor
NM_001080121.3 NP_001073590.1 major prion protein preproprotein Prp precursor
NM_001080122.3 NP_001073591.1 major prion protein preproprotein Prp precursor
NM_001080123.3 NP_001073592.1 major prion protein preproprotein Prp precursor
NM_001271561.3 NP_001258490.1 alternative prion protein isoform AltPrp
NM_183079.4 NP_898902.1 major prion protein preproprotein Prp precursor
NM_000311.5 NP_000302.1 major prion protein preproprotein Prp precursor
NM_001080121.3 NP_001073590.1 major prion protein preproprotein Prp precursor
NM_001080122.3 NP_001073591.1 major prion protein preproprotein Prp precursor
NM_001080123.3 NP_001073592.1 major prion protein preproprotein Prp precursor
NM_001271561.3 NP_001258490.1 alternative prion protein isoform AltPrp
NM_183079.4 NP_898902.1 major prion protein preproprotein Prp precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables amyloid-beta binding IDA
IDA: 通过直接分析推断
24012003 GOA
enables amyloid-beta binding IPI
IPI: 通过物理相互作用推断
22820466 GOA
enables copper ion binding IDA
IDA: 通过直接分析推断
11900542 GOA
enables cuprous ion binding IMP
IMP: 通过突变表型推断
20564047 GOA
enables identical protein binding IPI
IPI: 通过物理相互作用推断
16286452 GOA
enables microtubule binding IDA
IDA: 通过直接分析推断
16004966 GOA
enables molecular adaptor activity IDA
IDA: 通过直接分析推断
30401430 GOA
enables molecular condensate scaffold activity IDA
IDA: 通过直接分析推断
30401430 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
16286452 GOA
enables protein-containing complex binding IPI
IPI: 通过物理相互作用推断
23386614 GOA
enables tubulin binding IDA
IDA: 通过直接分析推断
16004966 GOA
NOT enables type 8 metabotropic glutamate receptor binding IDA
IDA: 通过直接分析推断
24012003 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to amyloid-beta IGI
IGI: 通过遗传相互作用推断
24012003 GOA
acts upstream of or within cellular response to copper ion IDA
IDA: 通过直接分析推断
16254249 GOA
involved in positive regulation of calcium-mediated signaling IGI
IGI: 通过遗传相互作用推断
24012003 GOA
involved in positive regulation of glutamate receptor signaling pathway IGI
IGI: 通过遗传相互作用推断
24012003 GOA
involved in positive regulation of neuron apoptotic process IMP
IMP: 通过突变表型推断
20564047 GOA
involved in positive regulation of peptidyl-tyrosine phosphorylation IDA
IDA: 通过直接分析推断
22820466 GOA
involved in protein destabilization IMP
IMP: 通过突变表型推断
20564047 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cell surface IDA
IDA: 通过直接分析推断
18419754 GOA
is active in dendrite IDA
IDA: 通过直接分析推断
24012003 GOA
located in inclusion body IMP
IMP: 通过突变表型推断
20564047 GOA
located in membrane raft IDA
IDA: 通过直接分析推断
16254249 GOA
located in membrane raft IMP
IMP: 通过突变表型推断
23386614 GOA
located in mitochondrial outer membrane IDA
IDA: 通过直接分析推断
21478263 GOA
located in plasma membrane IDA
IDA: 通过直接分析推断
16254249 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

PRNP 蛋白结构

Prion_bPrPp

Prion_bPrPp: Major prion protein bPrPp - N terminal (1 - 28)

Prion

Prion: Prion/Doppel alpha-helical domain (134 - 251)

  • 0
  • 100
  • 200
  • 253 a.a.
蛋白主名 其他名称

major prion protein

alternative prion protein

CD230 antigen

PRNP 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
PRNP P04156 MPG Homo sapiens P29372
IF
18482256
种属内
PRNP P04156 MPG Homo sapiens P29372 18482256
种属内
PRNP P04156 MPG Homo sapiens P29372 18482256
种属内
PRNP P04156 AZGP1 Homo sapiens P25311 28671123
种属内
PRNP P04156 AZGP1 Homo sapiens P25311 28671123
种属内
PRNP P04156 PIMREG Homo sapiens Q9BSJ6
IF
18482256
种属内
PRNP P04156 PIMREG Homo sapiens Q9BSJ6 18482256
种属内
PRNP P04156 APP Homo sapiens P05067-4 23236467
种属内
PRNP P04156 PRDX1 Homo sapiens Q06830 28671123
种属内
PRNP P04156 MAPT Homo sapiens P10636 24028865
种属内
PRNP P04156 F2RL1 Homo sapiens P55085 28298427
种属内
PRNP P04156 F2RL1 Homo sapiens P55085 28298427
种属内
PRNP P04156 F2RL1 Homo sapiens P55085 28298427
种属内
PRNP P04156 HTT Homo sapiens P42858 32814053
种属内
PRNP P04156 HTT Homo sapiens P42858 32814053
种属内
PRNP P04156 HTT Homo sapiens P42858 32814053
种属内
PRNP P04156 AGO1 Homo sapiens Q9UL18 22484317
种属内
PRNP P04156 AGO1 Homo sapiens Q9UL18 18482256
种属内
PRNP P04156 AGO2 Homo sapiens Q9UKV8 22484317
种属间
PRNP P04156 Ago2 Mus musculus Q8CJG0 22484317
种属内
PRNP P04156 HOXA1 Homo sapiens P49639
IF
18482256
种属内
PRNP P04156 HOXA1 Homo sapiens P49639 18482256
种属内
PRNP P04156 FZD7 Homo sapiens O75084 28298427
种属内
PRNP P04156 FZD7 Homo sapiens O75084 28298427
种属内
PRNP P04156 FZD7 Homo sapiens O75084 28298427
种属内
PRNP P04156 PLK3 Homo sapiens Q9H4B4
IF
18482256
种属内
PRNP P04156 PLK3 Homo sapiens Q9H4B4 18482256
种属内
PRNP P04156 PLK3 Homo sapiens Q9H4B4 18482256
种属间
PRNP P04156 Prnp Mus musculus P04925 22285492
种属内
PRNP P04156 APP Homo sapiens P05067 24028865
种属内
PRNP P04156 APP Homo sapiens P05067 32814053
种属内
PRNP P04156 APP Homo sapiens P05067 32814053
种属内
PRNP P04156 APP Homo sapiens P05067
SPR
16286452
种属内
PRNP P04156 APP Homo sapiens P05067 32814053
种属内
PRNP P04156 P05067-PRO_0000000092 Homo sapiens P05067-PRO_0000000092 23907583
种属内
PRNP P04156 P05067-PRO_0000000092 Homo sapiens P05067-PRO_0000000092 23907583
种属内
PRNP P04156 FHL1 Homo sapiens Q13642 18482256
种属内
PRNP P04156 FHL1 Homo sapiens Q13642 28671123
种属内
PRNP P04156 PRNP Homo sapiens P04156 16286452
种属内
PRNP P04156 PRNP Homo sapiens P04156 19204296
种属内
PRNP P04156 PRNP Homo sapiens P04156
CD
19278656
种属内
PRNP P04156 PRNP Homo sapiens P04156 18436646
种属内
PRNP P04156 PRNP Homo sapiens P04156
NMR
19278656
种属内
PRNP P04156 PRNP Homo sapiens P04156
SPR
16286452
种属内
PRNP P04156 PRNP Homo sapiens P04156
EPR
18025469
种属内
PRNP P04156 PRNP Homo sapiens P04156
EM
16286452
种属内
PRNP P04156 PRNP Homo sapiens P04156
AFM
19278656
种属内
PRNP P04156 PRNP Homo sapiens P04156
NMR
18436646
种属内
PRNP P04156 PRNP Homo sapiens P04156 19927125
种属内
PRNP P04156 PRNP Homo sapiens P04156
TEM
18025469
种属内
PRNP P04156 PRNP Homo sapiens P04156 19278656
种属内
PRNP P04156 PRNP Homo sapiens P04156
GMS
16286452
种属内
PRNP P04156 PRNP Homo sapiens P04156
TEM
19278656
种属内
PRNP P04156 PRNP Homo sapiens P04156
AFM
18436646
种属间
PRNP P04156 PRNP Bos taurus P10279
CD
21920025
种属间
PRNP P04156 PRNP Bos taurus P10279 22285492
种属间
PRNP P04156 PRNP Ovis aries P23907 22285492
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 PRNP 蛋白

目录号 产品名 蛋白编号 纯度
HY-P74619 PRNP/CD230 Protein, Human (HEK293, Fc) P04156/NP_000302.1 (K23-G229) ≥95%

PRNP 抗体

目录号 产品名 应用 反应物种
HY-P81980 Prion Protein Antibody (YA1725) WB, IHC-P Human, Mouse, Rat

关联疾病

疾病名称 别名
Creutzfeldt-Jakob Disease

Variant Creutzfeldt-Jakob Disease

CJD

Bovine Spongiform Encephalopathy

Vcjd

Inherited Creutzfeldt-Jakob Disease

Creutzfeldt-Jakob Disease, Familial

Creutzfeldt Jakob Disease

Creutzfeldt-Jacob Disease

Creutzfeldt Jacob Disease

Sporadic Creutzfeldt-Jakob Disease

Encephalopathy, Bovine Spongiform

Creutzfeldt-Jakob Disease, Variant, Resistance To

Creutzfeldt-Jakob Disease, Variant

Creutzfeldt Jacob Syndrome

Jakob-Creutzfeldt Disease

Subacute Spongiform Encephalopathy

Transmissible Virus Dementia

New Variant Of Cjd

Nv-Cjd

Variant Cjd

Variant Creutzfeldt-Jacob Disease

Sporadic Cjd

Inherited Cjd

Acquired Creutzfeldt-Jakob Disease

Variant Mcj

Encephalopathy Bovine Spongiform

Familial Creutzfeldt-Jakob Disease

Creutzfeldt-Jakob Syndrome

New Variant Creutzfeldt-Jakob Disease

Creutzfeldt-Jakob Disease, Sporadic

Acquired Cjd

Scjd - [Sporadic Creutzfeldt-Jakob Disease]

Idiopathic Creutzfeldt-Jakob Disease

Creutzfeld-Jakob Disease Nos

Vcjd - [Variant Creutzfeldt-Jakob Disease]

Fatal Familial Insomnia

Insomnia, Fatal Familial

FFI

Familial Fatal Insomnia

Insomnia Familial Fatal

Insomnia Fatal Familial

Insomnia, Fatal, Familial

Ffi - [Fatal Familial Insomnia]

Gerstmann-Straussler Disease

Gerstmann-Straussler-Scheinker Disease

Gerstmann-Straussler-Scheinker Syndrome

Prion Dementia

Cerebral Amyloid Angiopathy, Prnp-Related

GSD

Gss

Cerebellar Ataxia, Progressive Dementia, And Amyloid Deposits In Cns

Amyloidosis, Cerebral, With Spongiform Encephalopathy

Subacute Spongiform Encephalopathy, Gerstmann-Straussler Type

Encephalopathy, Subacute Spongiform, Gerstmann-Straussler Type

Amyloidosis Cerebral With Spongiform Encephalopathy

Cerebellar Ataxia, Progressive Dementia, And Amyloid Deposits In The Central Nervous System

Encephalopathy Subacute Spongiform Gerstmann-Straussler Type

Gssd

Gerstmann Straussler Scheinker Syndrome

Cerebral Amyloidosis With Spongiform Encephalopathy

Subacute Spongiform Encephalopathy Gerstmann-Straussler Type

Gluthathione Synthetase Deficiency

Gerstmann Straussler Syndrome

Huntington Disease-Like 1

HDL1

Huntington-Like Neurodegenerative Disorder 1

Hln1

Huntington'S Disease-Like 1

Early-Onset Prion Disease With Prominent Psychiatric Features

Huntington-Like Neurodegenerative Disorder, Autosomal Dominant

Prion Disease, Early-Onset, With Prominent Psychiatric Features

Autosomal Dominant Huntington-Like Neurodegenerative Disorder

Huntington Disease-Like, Type 1

Spongiform Encephalopathy With Neuropsychiatric Features

SENF

Kuru

Kuru, Susceptibility To

Kuru Encephalopathy

Kuru Encephalitis

Kuru Disease

Prion Disease

Spongiform Encephalopathy

Transmissible Spongiform Encephalopathies

Prion Diseases

Prion Disease Pathway

Transmissible Spongiform Encephalopathy

Prion Induced Disorder

Prion Protein Disease

Inherited Human Transmissible Spongiform Encephalopathies

Prion Protein Diseases

Prion-Associated Disorders

Prion-Induced Disorders

Transmissible Dementias

Tses

Human Prion Disease

Tse

Encephalopathy, Transmissible Spongiform

Prion Disease, Susceptibility To

Spongiform Encephalopathies

Human Transmissible Spongiform Encephalopathies, Inherited

Inherited Human Prion Disease

Inherited Prion Disease

Familial Prion Disease

Genetic Human Prion Disease

Familial Alzheimer-Like Prion Disease
Prp Systemic Amyloidosis

Chronic Diarrhea With Hsan

Chronic Diarrhea With Hereditary Sensory And Autonomic Neuropathy

Prion Protein Systemic Amyloidosis

Scrapie
Chronic Wasting Disease

Wasting Disease, Chronic

Frontotemporal Lobar Degeneration With Tdp43 Inclusions, Grn-Related

Primary Progressive Aphasia

Grn-Related Frontotemporal Lobar Degeneration With Tdp43 Inclusions

Frontotemporal Lobar Degeneration With Ubiquitin-Positive Inclusions

Frontotemporal Dementia, Ubiquitin-Positive

Aphasia, Primary Progressive

Ppa

Ftld-Tdp, Grn-Related

Frontotemporal Dementia With Tdp43 Inclusions, Grn-Related

Ftldu

Ftdu

Dementia, Hereditary Dysphasic Disinhibition

Hddd

Primary Progressive Aphasia Syndrome

Mesulam Syndrome

Ubiquitin-Positive Frontotemporal Dementia

UP-FTD

Tau-Negative Frontotemporal Dementia Linked To Chromosome 17

Aphasia Primary Progressive

Frontotemporal Lobar Degeneration With Ubiquitin-Positive Inclusions, Susceptibility To

Aphasia, Primary Progressive, Susceptibility To

Frontotemporal Dementia

Dementia

Dementias

Presenile Dementia

Alzheimer Type Dementia

Alzheimer Sclerosis

Alzheimer Disease Dementia

Alzheimer Dementia

Primary Degenerative Alzheimer Type Dementia

End Stage Alzheimer'S Dementia

Alzheimer'S Type Atypical Dementia

Alzheimer Type Presenile Dementia

Early Onset Alzheimer Dementia

Dementia In Alzheimer Disease Type 2

Dementia In Alzheimer Disease With Early Onset

Early Onset Alzheimer Type Dementia, Uncomplicated

Primary Degenerative Alzheimer Type Dementia, Early Onset

Primary Degenerative Alzheimer Type Dementia, Presenile Onset, Uncomplicated

Alzheimer Disease Dementia With Early Onset

Presenile Sclerosis

Presenile Brain Sclerosis

Presenile Alzheimer Brain Sclerosis

Late Onset Alzheimer Dementia

Dementia In Alzheimer Disease Type 1

Dementia In Alzheimer Disease With Late Onset

Primary Degenerative Alzheimer Type Dementia, Late Onset

Sdat - [Senile Dementia, Alzheimer Type]

Alzheimer Disease Dementia With Late Onset

Late Onset Alzheimer Brain Sclerosis

Senile Alzheimer Brain Disease

Senile Alzheimer Brain Sclerosis

Senile Primary Degenerative Alzheimer Type Dementia

Senile Dementia Of The Alzheimer Type

Arteriosclerotic Dementia

Strategic-Infarct Dementia

Post Stroke Dementia

Vascular Cognitive Impairment

Vascular Dementia

Dementia Of The Lewy Body Type

Dementia With Lewy Bodies

Sdlt - [Senile Dementia Of The Lewy Body Type]

Senile Dementia Of The Lewy Body Type

Alcohol-Related Dementia

Alcoholic Dementia Nos

Alcohol-Induced Dementia

Alcoholic Brain Syndrome

Chronic Alcoholic Brain Syndrome

Alcohol Dementia

Late Onset Alcoholic Psychosis

Residual And Late-Onset Alcohol-Induced Psychotic Disorder

Mental And Behavioural Disorders Due To Use Of Sedatives Or Hypnotics, Residual And Late-Onset Psychotic Disorder

Late-Onset Psychoactive Substance-Induced Psychotic Disorder

Inhalant Dementia

Volatile Solvents Dementia

Dementia In Paralysis Agitans

Pdd - [Parkinson Disease Dementia]

Dementia Syndrome Of Parkinson Disease

Dementia In Parkinson Disease

Parkinson Related Dementia

Dementia In Huntington Chorea

Hiv - [Human Immunodeficiency Virus] Dementia

Hiv- [Human Immunodeficiency Virus] Associated Cognitive Motor Complex

Hiv- [Human Immunodeficiency Virus] Associated Dementia Complex

Aids - [Acquired Immunodeficiency Syndrome] Dementia Complex

Aids Related Dementia

Dementia Due To Niacin Deficiency

Huntington Disease

Huntington'S Disease

Huntington Chorea

Huntington'S Chorea

HD

Huntington Chronic Progressive Hereditary Chorea

Juvenile Huntington Disease

Chronic Progressive Chorea

Chronic Progressive Hereditary Chorea

Hc - [Huntington Chorea]

Hereditary Chorea

Progressive Hereditary Chorea

Encephalopathy

Brain Diseases

Encephalopathies

Toxic Encephalopathy

Toxic Brain Fever

Toxic Brain Inflammation

Toxic Brain Stem Inflammation

Toxic Cerebral Fever

Toxic Cerebrospinal Fever

Toxic Cerebrospinal Inflammation

Encephalopathy Nec

Encephalopathy Nos

Encephalopathy Disease

Encephalopathy Syndrome

Cerebral Amyloid Angiopathy, Cst3-Related

Cerebral Amyloid Angiopathy

Hereditary Cerebral Hemorrhage With Amyloidosis

Hchwa

Hereditary Cystatin C Amyloid Angiopathy

Cerebral Amyloid Angiopathy, Familial

Amyloidosis, Cerebroarterial, Icelandic Type

Amyloidosis Vi

Cerebral Hemorrhage, Hereditary, With Amyloidosis

Cst3-Related Cerebral Amyloid Angiopathy

Cerebral Hemorrhage, Hereditary, With Amyloidosis, Icelandic Variant

Hereditary Cerebral Hemorrhage With Amyloidosis, Icelandic Variant

Caa, Familial

Cerebral Amyloid Angiopathy, Genetic

Acys Amyloidosis

Cst3-Related Amyloidosis

Cystatin Amyloidosis

Hchwa, Icelandic Type

Hereditary Cerebral Hemorrhage With Amyloidosis, Icelandic Type

Amyloidosis 6

AMYL6

Acys

Caa

Cerebral Amyloid Angiopathy Cst3-Related

Cerebroarterial Amyloidosis Icelandic Type

Cystatin C Amyloidosis

Hccaa

Hchwai

Hchwa-I

Hereditary Cerebral Hemorrhage With Amyloidosis Icelandic Type

Cerebral Amyloid Angiopathy Familial

Angiopathy, Amyloid, Cerebral, Cst3-Related

Hereditary Cerebral Amyloid Angiopathy, Icelandic Type

Familial Cerebral Amyloid Angiopathy

Cerebral Amyloid Angiopathy, Hereditary

Amyloidosis

Amyloid Disease

Amyloid

Amyloid Degeneration

Amyloidosis Nos

Amyloid Deposition

Amyloid Infiltration

Idiopathic Amyloidosis

Hyaloid Degeneration

Lardaceous Degeneration

Akinetic Mutism

Coma Vigilans

Aphasia
Wilson Disease

Hepatolenticular Degeneration

WD

Wilson'S Disease

WND

Westphal-Strumpell Syndrome

Copper Storage Disease

Cerebral Pseudosclerosis

Westphal Pseudosclerosis

Hepatolenticular Degeneration Syndrome

Copper Retention

Hepatocerebral Degeneration

Kinnier-Wilson Disease

Neurohepatic Degeneration

Progressive Hepatolenticular Degeneration

Lenticular Degenerative Disease

Wilson'S Syndrome

Lenticular Syndrome

Visual Cortex Disease

Visual Cortex Dysfunction

Visual Cortex Disorder

Visual Cortical Disorder

Disease Of Visual Cortex

Vascular Dementia

Dementia, Vascular

Multi Infarct Dementia

Multifocal Dementia

Dementia Vascular

Vascular Dementia, Susceptibility To

Dementia, Multi-Infarct

Multi-Infarct Dementia

Visual Pathway Disease

Disorder Of Visual Pathways

Dementia, Lewy Body

Lewy Body Dementia

Lewy Body Disease

Diffuse Lewy Body Disease

Dementia With Lewy Bodies

DLB

Autosomal Dominant Diffuse Lewy Body Disease

Cortical Lewy Body Disease

Dementia, Lewy Body, Susceptibility To

Lewy Body Dementia, Susceptibility To

Senile Dementia Of The Lewy Body Type

Dementia Of The Lewy Body Type

Lbd

Diffuse Lewy Body Disease With Gaze Palsy

Dysphasic Dementia Hereditary

Lewy Body Type Senile Dementia

Lewy Body Variant Of Alzheimer Disease

Lewy Bodies

Lewy Body

Dlbd - [Diffuse Lewy Body Disease]

Clbd - [Cortical Lewy Body Disease]

Dentatorubral-Pallidoluysian Atrophy

DRPLA

Naito-Oyanagi Disease

Haw River Syndrome

Myoclonic Epilepsy With Choreoathetosis

Nod

Ataxia, Chorea, Seizures, And Dementia

Dentatorubropallidoluysian Atrophy

Hrs

Naito Oyanagi Disease

Dentatorubral Pallidoluysian Atrophy

Dentatorubro-Pallidoluysian Atrophy

Myoclonic Epilepsies, Progressive

Atrophy, Pallidoluysian, Dentatorubral

Temporal Lobe Epilepsy

Epilepsy, Temporal Lobe

Epilepsy Temporal Lobe

Louping Ill
Neuroblastoma

Nb

Neuroblastoma, Susceptibility To

Neuroblastomas

Central Neuroblastoma

Multiple System Atrophy 1

Multiple System Atrophy

Shy-Drager Syndrome

Msa

MSA1

Multiple System Atrophy 1, Susceptibility To

Sporadic Olivopontocerebellar Atrophy

Multisystem Atrophy

Msa1, Susceptibility To

Multiple System Atrophy, Susceptibility To

Opca

Progressive Autonomic Failure With Multiple System Atrophy

Sds

Frontotemporal Dementia

Pallidopontonigral Degeneration

Frontotemporal Lobar Degeneration

Semantic Dementia

FTD

Frontotemporal Lobe Dementia

Multiple System Tauopathy With Presenile Dementia

Dementia, Frontotemporal

Frontotemporal Dementia With Parkinsonism

Mstd

Frontotemporal Lobar Degeneration With Tau Inclusions

Ftld With Tau Inclusions

Dementia, Frontotemporal, With Parkinsonism

Fldem

Ftdp17

Disinhibition-Dementia-Parkinsonism-Amyotrophy Complex

Ddpac

Wilhelmsen-Lynch Disease

Wld

Ppnd

Dementia, Frontotemporal, With Or Without Parkinsonism

Semantic Primary Progressive Aphasia

Semantic Variant Ppa

Wilhemsen-Lynch Disease

Frontotemporal Dementia-Amyotrophic Lateral Sclerosis

Frontotemporal Dementia And Parkinsonism Linked To Chromosome 17

Ftd-Als

Ftld

Pick Complex

Pick Disease Of The Brain

Frontotemporal Dementia With Parkinsonism-17

Grn-Related Frontotemporal Dementia

Frontotemporal Dementia With Motor Neuron Disease

Dementia In Fronto-Temporal Lobar Degeneration

Ftd - [Frontotemporal Dementia]

Temple Dementia

Frontal Lobe Dementia

Supranuclear Palsy, Progressive, 1

Progressive Supranuclear Palsy

Steele-Richardson-Olszewski Syndrome

Supranuclear Palsy, Progressive

Progressive Supranuclear Ophthalmoplegia

Psp

PSNP1

Familial Progressive Supranuclear Palsy

Richardson'S Syndrome

Psp Syndrome

Progressive Supranuclear Palsy 1

Supranuclear Palsy Progressive

Ophthalmoplegia, Supranuclear, Progressive

Steele-Richardson-Olszewksi Syndrome

Autosomal Dominant Cerebellar Ataxia

Spinocerebellar Ataxia

Adca

Pierre Marie Cerebellar Ataxia

Ataxia, Spinocerebellar

Sca

Autosomal Dominant Spinocerebellar Ataxia

Spinocerebellar Ataxias

Agraphia
Ideomotor Apraxia

Apraxia, Ideomotor

Classic Apraxia

Ideomotor Dyspraxia

Limb-Kinetic Apraxia

Transcortical Apraxia

Spinocerebellar Ataxia 12

Spinocerebellar Ataxia Type 12

SCA12

Ataxia, Spinocerebellar, Type 12

Alzheimer Disease, Familial, 1

Alzheimer Disease

Alzheimer'S Disease

Presenile And Senile Dementia

AD1

Alzheimer Disease, Susceptibility To

Alzheimer Disease, Late-Onset, Susceptibility To

Alzheimer Disease 1, Familial

AD

Familial Alzheimer Disease

Alzheimer Disease, Late-Onset

Alzheimers Dementia

Alzheimer Dementia

Alzheimer Sclerosis

Alzheimer Syndrome

Alzheimer-Type Dementia

Dat

Primary Senile Degenerative Dementia

Sdat

Alzheimer Disease 1

Autosomal Dominant Alzheimer Disease

Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy

Late Onset Alzheimer Disease

Alzheimers Disease

Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy

Late-Onset Alzheimers Disease

Alzheimer'S Disease Pathway Kegg

Dementia Due To Alzheimer'S Disease

Alzheimer Disease Type 1

Alzheimers

Gerstmann Syndrome

Aphasia-Angular Gyrus Syndrome

Developmental Gerstmann Syndrome

Gs

Gerstmann Badal Syndrome

Gerstmann Tetrad

Gerstmann'S Syndrome

Developmental Gerstmann'S Syndrome

Writing Disorder
Gait Apraxia
Cortical Blindness

Blindness, Cortical

Speech And Communication Disorders

Language Disorder

Communication Disorder

Language Disorders

Communication Disorders

Speech Language Disorder

Speech-Language Disorder

Communication Impairment

Speech And Language Disorder

Dystonia 25

DYT25

Dystonia-25

Dystonia, Type 25

Torsion Dystonia 2

Dystonia 2, Torsion, Autosomal Recessive

Alexia

Dyslexia

Dyslexia, Acquired

Acquired Dyslexia

Aphemesthaesia

Cerebral Amyloid Angiopathy, Itm2b-Related, 1

Dementia, Familial British

Fbd

Presenile Dementia With Spastic Ataxia

Familial British Dementia

Abri Amyloidosis

Cerebral Amyloid Angiopathy, British Type

Itm2b-Related Cerebral Amyloid Angiopathy 1

Familial Dementia, British Type

Cerebral Amyloid Angiopathy, Itm2b-Related 1

CAA-ITM2B1

Cerebral Amyloid Angiopathy British Type

Dementia, Familial, British

Mutism
Visual Agnosia

Primary Visual Agnosia

Pseudobulbar Palsy

Pseudobulbar Paralysis

Spinocerebellar Ataxia 45

SCA45

Spinocerebellar Ataxia Type 45

Pick Disease Of Brain

Pick Disease

Pick'S Disease

Pick Disease Of The Brain

Lobar Atrophy Of Brain

Dementia With Lobar Atrophy And Neuronal Cytoplasmic Inclusions

Behavioral Variant Of Frontotemporal Dementia

Dementia In Pick'S Disease

Lobar Atrophy Of The Brain

Bvftd

Bv-Ftd

PIDB

Picks Disease

Akinetopsia
Toxic Encephalopathy

Neurotoxicity

Neurotoxicity Syndromes

Neurotoxicity Syndrome

Encephalopathy, Toxic

Myopathy

Muscular Diseases

Myopathies

Cortical Deafness
Epilepsy

Epilepsy Syndrome

Epileptic Syndrome

Epilepsies

Symptomatic Epilepsies

Post Traumatic Epilepsy

Traumatic Epilepsy

Traumatic Epileptic

Epilepsy Due To Hippocampal Sclerosis

Epilepsy With Ammon'S Horn Sclerosis

Epilepsy Due To Cortical Dysplasia

Epilepsy Due To Neuronal Migration Disorders

Amyotrophic Lateral Sclerosis 1

Amyotrophic Lateral Sclerosis

ALS

Lou Gehrig Disease

Amyotrophic Lateral Sclerosis Type 1

Charcot Disease

ALS1

Amyotrophic Lateral Sclerosis, Susceptibility To

Fals

Lou Gehrig'S Disease

Mnd

Motor Neuron Disease

Familial Amyotrophic Lateral Sclerosis

Amyotrophic Lateral Sclerosis 1, Familial

Amyotrophic Lateral Sclerosis 1, Autosomal Dominant

Motor Neuron Disease, Bulbar

Motor Neurone Disease

Amyotrophic Lateral Sclerosis With Dementia

Dementia With Amyotrophic Lateral Sclerosis

Motor Neuron Disease, Amyotrophic Lateral Sclerosis

Sclerosis, Lateral, Amyotrophic

Sclerosis, Lateral, Amyotrophic, Type 1

Amyotrophic Sclerosis

Als - [Amyotrophic Lateral Sclerosis]

Wasting Palsy

Amyotrophic Paralysis

Amyotrophy Lateral Sclerosis

Wasting Paralysis

Spinal Progressive Amyotrophy

Progressive Atrophic Paralysis

Warburg Micro Syndrome 3

WARBM3

Micro Syndrome 3

Warburg Micro Syndrome 2

WARBM2

Micro Syndrome 2

Choreatic Disease

Chorea

Hereditary Chorea

Neuromuscular Disease

Neuromuscular Diseases

Neuromuscular Disorders

Neuromuscular Disorder

Cerebellar Disease

Cerebellar Diseases

Cerebellar Dysfunction

Cerebellar Abnormality

Cerebellar Disorders

Movement Disease

Movement Disorders

Movement Disorder

Nervous System Disease

Abnormality Of The Nervous System

Nervous System Diseases

Nervous System Disorder

Parkinson Disease, Late-Onset

Parkinson Disease

Parkinson'S Disease

PD

PARK

Parkinson Disease, Susceptibility To

Late Onset Parkinson'S Disease

Late Onset Parkinson Disease

Paralysis Agitans

Primary Parkinsonism

Idiopathic Parkinson Disease

Parkinson'S

Parkinson Disease, Late-Onset, Susceptibility To

Parkinson Disease, Age Of Onset, Modifier

Lewy Body Parkinson Disease

Idiopathic Parkinson'S Disease

Pd - [Parkinson Disease]

Parkinson Disease Nos

Parkinson, Nos

Primary Parkinson Disease

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Felis catus PRNP VGNC VGNC:81156
Rattus norvegicus PRNP RGD RGD:3410
Canis familiaris PRNP VGNC VGNC:45004
Bos taurus PRNP VGNC VGNC:33356
Macaca mulatta PRNP VGNC VGNC:76424
Mus musculus PRNP MGD MGI:97769
Others PRNP NCBI