蛋白 S/PROS1 蛋白, Human (HEK293, His)

Protein S/PROS1 Proteinas are potent antagonists of BMP4 and inhibit BMP4 by binding to BMP4 and preventing receptor interaction. This change redirects neural stem cells from gliogenesis to neurogenesis, thereby promoting the differentiation of neurons in the brain. Protein S/PROS1 Protein, Human (HEK293, His) is the recombinant human-derived protein S/PROS1 protein, expressed by HEK293 , with C-His labeled tag.

类弦蛋白 1 (CHRDL1) 蛋白是 BMP4 的有效拮抗剂，通过与 BMP4 结合并阻止其与受体相互作用来发挥其抑制功能。这种相互作用导致神经干细胞命运承诺的关键改变，引导它们从胶质生成转向神经发生。在大脑中，CHRDL1 通过阻止神经胶质细胞命运的形成，促进神经干细胞分化为神经元。除了在神经发育中的作用之外，CHRDL1 可能在背腹轴形成和胚胎骨发育中发挥至关重要的作用。此外，CHRDL1 作为视网膜血管生成的调节剂出现，调节内皮细胞中 BMP4 的作用。它参与眼前段眼睛发育，进一步强调了 CHRDL1 在协调关键发育过程中的多方面作用。

Measured by its binding ability in a functional ELISA.When Recombinant Human Tyro3/Dtk (HY-P78657) is immobilized at 1 μg/mL, 100 μL/well, Recombinant Human Protein S/PROS1 binds with an ED₅₀ of 0.04361 μg/mL.

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  Measured by its binding ability in a functional ELISA.When Recombinant Human Tyro3/Dtk (HY-P78657) is immobilized at 1 μg/mL, 100 μL/well, Recombinant Human Protein S/PROS1 binds with an ED₅₀ of 0.04361 μg/mL.

Human

HEK293

C-10*His

P07225 (N25-S676)

5627  [NCBI]

NFLSKQQASQVLVRKRRANSLLEETKQGNLERECIEELCNKEEAREVFENDPETDYFYPKYLVCLRSFQTGLFTAARQSTNAYPDLRSCVNAIPDQCSPLPCNEDGYMSCKDGKASFTCTCKPGWQGEKCEFDINECKDPSNINGGCSQICDNTPGSYHCSCKNGFVMLSNKKDCKDVDECSLKPSICGTAVCKNIPGDFECECPEGYRYNLKSKSCEDIDECSENMCAQLCVNYPGGYTCYCDGKKGFKLAQDQKSCEVVSVCLPLNLDTKYELLYLAEQFAGVVLYLKFRLPEISRFSAEFDFRTYDSEGVILYAESIDHSAWLLIALRGGKIEVQLKNEHTSKITTGGDVINNGLWNMVSVEELEHSISIKIAKEAVMDINKPGPLFKPENGLLETKVYFAGFPRKVESELIKPINPRLDGCIRSWNLMKQGASGIKEIIQEKQNKHCLVTVEKGSYYPGSGIAQFHIDYNNVSSAEGWHVNVTLNIRPSTGTGVMLALVSGNNTVPFAVSLVDSTSEKSQDILLSVENTVIYRIQALSLCSDQQSHLEFRVNRNNLELSTPLKIETISHEDLQRQLAVLDKAMKAKVATYLGGLPDVPFSATPVNAFYNGCMEVNINGVQLDLDEAISKHNDIRAHSCPSVWKKTKNS

Approximately 78-98 kDa due to the glycosylation.

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  Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末

Lyophilized from a 0.2 μm filtered solution of PBS, pH 8.0, 8% trehalose.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.