PTGDS 蛋白, Human (HEK293, His)

The PTGDS protein catalyzes the conversion of PGH2 to PGD2, a prostaglandin that affects smooth muscle activity and platelet aggregation. It plays a role in central nervous system functions such as sedation, sleep, and allodynia. PTGDS Protein, Human (HEK293, His) is the recombinant human-derived PTGDS protein, expressed by HEK293 , with C-6*His labeled tag. The total length of PTGDS Protein, Human (HEK293, His) is 168 a.a., with molecular weight of 20-29 kDa.

PTGDS 蛋白在各种生理过程中发挥多方面的作用。它催化 PGH2 转化为 PGD2，后者是一种前列腺素，与平滑肌收缩/松弛有关，也是血小板聚集的有效抑制剂。除了参与这些血管功能之外，PTGDS 在多种中枢神经系统 (CNS) 活动中发挥着至关重要的作用，包括镇静、NREM 睡眠和 PGE2 诱导的异常性疼痛，并且可能在少突胶质细胞中表现出抗凋亡功能。值得注意的是，PTGDS 具有广泛的底物结合能力，可与胆绿素、胆红素、视黄醛、视黄酸和甲状腺激素等小非底物亲脂性分子相互作用。这表明它具有作为有害疏水分子的清除剂以及作为分泌性视黄醇和甲状腺激素的转运蛋白的潜在作用。此外，PTGDS还参与多种血液屏障的形成和维持，包括血脑、血-视网膜、血-房水和血-睾丸屏障，表明其在屏障功能中的重要性。此外，它在中枢神经系统和男性生殖系统的成熟和维持中发挥着重要作用，并参与肥大细胞的PLA2G3依赖性成熟，进一步强调了它在多种生物过程中的复杂参与。

Measured by its ability to catalyse the conversion of PGH2 to PGD2. The specific activity is 5.207 pg/min/µg that incubate at 25 ºC for 1 minutes.

Human

HEK293

C-6*His

P41222 (A23-Q190)

5730  [NCBI]

APEAQVSVQPNFQQDKFLGRWFSAGLASNSSWLREKKAALSMCKSVVAPATDGGLNLTSTFLRKNQCETRTMLLQPAGSLGSYSYRSPHWGSTYSVSVVETDYDQYALLYSQGSKGPGEDFRMATLYSRTQTPRAELKEKFTAFCKAQGFTEDTIVFLPQTDKCMTEQ

20-29 kDa

Greater than 95% as determined by reducing SDS-PAGE.

溶液.

Supplied as a 0.2 μm filtered solution of 20 mM Tris-HCl, 150 mM NaCl, 10%Glycerol, pH 7.5.

<1 EU/μg, determined by LAL method.

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.