1. Gene
  2. PTGDS - prostaglandin D2 synthase Gene

PTGDS - prostaglandin D2 synthase Gene

中文名称:前列腺素 D2 合酶

种属: Homo sapiens

同用名: PDS; PGD2; PGDS; LPGDS; PGDS2; L-PGDS

基因 ID: 5730 | 基因类型: protein coding

关于 PTGDS

Cytogenetic location: 9q34.3 Genomic coordinates (GRCh38): 9:136,977,504-136,981,742 (from NCBI)

This gene has 10 transcripts (splice variants), 161 orthologues and 12 paralogues. Biased expression in testis (RPKM 1025.8), heart (RPKM 481.7) and 13 other tissues.

功能概要

该基因编码的蛋白质是一种不依赖于谷胱甘肽的前列腺素 D 合酶,可催化前列腺素 H2 (PGH2) 向前列腺素 D2 (PGD2) 的转化。 PGD2 在中枢神经系统中充当神经调节剂和营养因子。 PGD2 还参与平滑肌收缩/松弛,是一种有效的血小板聚集抑制剂。该基因优先在大脑中表达。对过度表达该基因的转基因小鼠的研究表明,该基因也可能参与非快动眼睡眠的调节。[RefSeq 提供,2008 年 7 月]

The protein encoded by this gene is a glutathione-independent prostaglandin D synthase that catalyzes the conversion of prostaglandin H2 (PGH2) to postaglandin D2 (PGD2). PGD2 functions as a neuromodulator as well as a trophic factor in the central nervous system. PGD2 is also involved in smooth muscle contraction/relaxation and is a potent inhibitor of platelet aggregation. This gene is preferentially expressed in brain. Studies with transgenic mice overexpressing this gene suggest that this gene may be also involved in the regulation of non-rapid eye movement sleep. [provided by RefSeq, Jul 2008]

PTGDS 基因产物(1)

mRNA Protein Name
NM_000954.6 NP_000945.3 prostaglandin-H2 D-isomerase precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables fatty acid binding IDA
IDA: 通过直接分析推断
20667974 GOA
enables prostaglandin-D synthase activity IDA
IDA: 通过直接分析推断
20347284 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
16713569 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in prostaglandin biosynthetic process IDA
IDA: 通过直接分析推断
20347284 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in extracellular region IDA
IDA: 通过直接分析推断
7692978 GOA
located in extracellular space IDA
IDA: 通过直接分析推断
19878301 GOA
located in rough endoplasmic reticulum IDA
IDA: 通过直接分析推断
9065498 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

PTGDS 蛋白结构

Lipocalin

Lipocalin: Lipocalin / cytosolic fatty-acid binding protein family (41 - 184)

  • 0
  • 100
  • 190 a.a.
蛋白主名 其他名称

prostaglandin-H2 D-isomerase

PGD2 synthase

重组 PTGDS 蛋白

目录号 产品名 蛋白编号 纯度
HY-P71242 PTGDS Protein, Human (HEK293, His) P41222 (A23-Q190) ≥95%
HY-P71242A PTGDS Protein, Human (HEK293, C-His) P41222 (A23-Q190) ≥95%

关联疾病

疾病名称 别名
Intracranial Hypotension
Normal Pressure Hydrocephalus

Low Pressure Hydrocephalus

Hydrocephalus Normal Pressure

Hydrocephalus, Normal Pressure

Normal Pressure Hydrocephalus Nos

Nph - [Normal Pressure Hydrocephalus]

Normal Pressure Hydrocephaly

Cerebrospinal Fluid Leak

Csf Leak

Csf Otorrhea

Csf Rhinorrhea

Spinal Csf Leak

Spinal Cerebrospinal Fluid Leak

Cerebrospinal Fluid Rhinorrhea

Egg Allergy

Allergy To Eggs

Allergies Egg

Egg Hypersensitivity

Macular Holes

Macular Hole

Complete Androgen Insensitivity Syndrome

Cais

Complete Androgen Resistance Syndrome

Androgen Insensitivity Syndrome Complete

Androgen Insensitivity, Complete

Androgen-Insensitivity Syndrome

Testicular Feminization

Idiopathic Hypersomnia

Primary Hypersomnia

Idiopathic Hypersomnolence

Idiopathic Excessive Sleepiness

Hypersomnolence, Idiopathic

Disorder Of Excessive Somnolence

Hypersomnia

Excessive Somnolence

Hypersomnia

Hypersomnia Due To Substances Including Medications

Hypersomnolence Due To Substances Including Medications

Multiple Sclerosis

MS

Multiple Sclerosis, Susceptibility To

Disseminated Sclerosis

Multiple Sclerosis, Disease Progression, Modifier Of

Insular Sclerosis

Multiple Sclerosis Modifier Of Disease Progression

Multiple Sclerosis, Susceptibility To 1

Multiple Sclerosis, Susceptibility To, 1

Multiple Sclerosis 1

Generalized Multiple Sclerosis

Multiple Sclerosis Variant

Multiple Sclerosis Susceptibility To

Cerebrospinal Sclerosis

Generalised Multiple Sclerosis

Ms - [Multiple Sclerosis]

Disseminated Cerebrospinal Sclerosis

Disseminated Multiple Sclerosis

Disseminated Nervous System Myelosclerosis

Multiple Cerebrospinal Sclerosis

Multiple Combined Sclerosis

Multiple Sclerosis Generalised

Disseminated Brain Sclerosis

Disseminated Spinal Sclerosis

Insular Brain Sclerosis

Miliary Brain Sclerosis

Multiple Combined Sclerosis Of Spinal Cord

Multiple Ascending Sclerosis

Multiple Brain Sclerosis

Multiple Sclerosis Of Brain Stem

Multiple Sclerosis Of The Brain Stem

Multiple Sclerosis Of Cord

Sclérose En Plaques

Plaque Sclerosis

Multiple Sclerosis Of The Spinal Cord

Otorrhea

Discharging Ear

Intracranial Abscess

Abscess Of Brain

Brain Empyema

Cranial Abscess

Intracerebral Abscess

Cerebral Abscess

Cerebral Embolic Abscess

Cerebral Pyogenic Abscess

Septic Brain Infection

Temporosphenoidal Abscess

Ventricular Empyema

Intracranial Suppuration

Intracranial Vein Sinus Abscess

Orbital Cyst
Androgen Insensitivity Syndrome

Androgen Resistance Syndrome

AIS

Testicular Feminization Syndrome

Androgen Receptor Deficiency

Dhtr Deficiency

Dihydrotestosterone Receptor Deficiency

Ar Deficiency

Testicular Feminization

Tfm

Androgen Insensitivity

Androgen-Insensitivity Syndrome

Goldberg-Maxwell Syndrome

Complete Androgen Insensitivity Syndrome

Cais

Feminisation - Testicular

Goldberg - Maxwell Syndrome

Androgen Insensitivity Syndrome, Complete

Morris Syndrome

Ary

AR

Insensitivity Syndrome, Androgen

Androgen Insensitivity Nos

Congenital Disorder Of Glycosylation, Type In

Congenital Disorder Of Glycosylation

CDG1N

Congenital Disorders Of Glycosylation

Cdg In

Cdgin

Congenital Disorder Of Glycosylation 1n

Carbohydrate-Deficient Glycoprotein Syndrome

Cdg

Rft1-Cdg

Cdg-In

Congenital Disorder Of Glycosylation Type In

Carbohydrate Deficient Glycoprotein Syndrome

Cdg Syndrome

Congenital Disorder Of Glycosylation In

Carbohydrate-Deficient Glycoprotein Syndromes

Cdg Syndrome Type In

Carbohydrate Deficient Glycoprotein Syndrome Type In

Congenital Disorder Of Glycosylation Type 1n

Man5glcnac2-Pp-Dol Flippase Deficiency

Glycosylation, Congenital Disorder Of

Glycosylation, Congenital Disorder Of, Type In

Beach Ear

Acute Swimmer'S Ear

Acute Bacterial Inflammation Of External Ear

Acute Otitis Externa, Diffuse

Acute Swimmers' Ear

Tank Ear

Disorder Of Sexual Development

Disorder Of Sex Development

Disorders Of Sex Development

Sex Development Disorder

Sex Differentiation Disease

Dsd

Sex Differentiation Disorders

Pulsating Exophthalmos
Diabetes Mellitus

Diabetes

Fabry Disease

Alpha-Galactosidase A Deficiency

Anderson-Fabry Disease

Angiokeratoma Corporis Diffusum

Ceramide Trihexosidase Deficiency

Fabry Disease, Cardiac Variant

Fabry'S Disease

Hereditary Dystopic Lipidosis

Gla Deficiency

FD

Alpha Galactosidase Deficiency

Deficiency Of Melibiase

Angiokeratoma, Diffuse

Angiokeratoma Diffuse

Diffuse Angiokeratoma

Narcolepsy

Paroxysmal Sleep

Gelineau Syndrome

Narcoleptic Syndrome

Narcolepsy-Cataplexy Syndrome

Cataplexy And Narcolepsy

Narcolepsy, Without Cataplexy

Gelineau'S Syndrome

Narcolepsy With Or Without Cataplexy

Narcolepsy Nos

Fibrous Meningioma

Fibroblastic Meningioma

Meningocele

Isolated Spina Bifida

Spina Bifida

Cleft Spine

Open Spine

Rachischisis

Spinal Dysraphism

Spinal Meningocele

Congenital Meningocele

Hydrocephalus

Hydrocephalus, Nonsyndromic, Autosomal Recessive

Hydrocephalus, X-Linked

Hydrocephalus Adverse Event

Hydrocephaly Nos

Communicating Hydrocephalus

Acquired Communicating Hydrocephalus

Meningioma, Familial

Meningioma

Familial Meningioma

Meningioma, Familial, Susceptibility To

Meningeal Neoplasm

Meningeal Neoplasms

Meningiomas

Meningioma, Nf2-Related, Somatic

Meningioma, Sis-Related

Meningothelial Cell Tumor

Neoplasm Of The Meninges

Primary Meningeal Tumor

Familial Multiple Meningioma

MNGMA

Meningioma, Benign, No Icd-O Subtype

Intracranial Meningioma

Meningothelial Cell Neoplasm

Supratentorial Meningioma

Primary Neoplasm Of Spinal Meninges

Benign Intracranial Meningioma

Benign Meningioma

Meningeal Tumours

Meningeal Sarcoma Of Unspecified Site

Meningothelial Sarcoma Of Unspecified Site

Schizophrenia

SCZD

Schizophrenia With Or Without An Affective Disorder

Schizophrenia 12

Schizophrenia, Susceptibility To

Schizophrenia-1

Dementia Praecox

Schizophrenia 1

Alzheimer Disease, Familial, 1

Alzheimer Disease

Alzheimer'S Disease

Presenile And Senile Dementia

AD1

Alzheimer Disease, Susceptibility To

Alzheimer Disease, Late-Onset, Susceptibility To

Alzheimer Disease 1, Familial

AD

Familial Alzheimer Disease

Alzheimer Disease, Late-Onset

Alzheimers Dementia

Alzheimer Dementia

Alzheimer Sclerosis

Alzheimer Syndrome

Alzheimer-Type Dementia

Dat

Primary Senile Degenerative Dementia

Sdat

Alzheimer Disease 1

Autosomal Dominant Alzheimer Disease

Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy

Late Onset Alzheimer Disease

Alzheimers Disease

Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy

Late-Onset Alzheimers Disease

Alzheimer'S Disease Pathway Kegg

Dementia Due To Alzheimer'S Disease

Alzheimer Disease Type 1

Alzheimers

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus PTGDS RGD RGD:3433
Mus musculus PTGDS MGD MGI:99261
Canis familiaris PTGDS VGNC VGNC:55792
Others PTGDS NCBI