1. 重组蛋白
  2. Enzymes & Regulators
  3. Hydrolases (EC 3)
  4. PTP4A3 蛋白, Human (His)

PTP4A3 蛋白, Human (His)

目录号: HY-P701033
产品使用指南

PTP4A3 蛋白是一种酪氨酸磷酸酶,可加速细胞周期从 G1 期进展到 S 期,促进细胞增殖、运动和侵袭。它的作用延伸到促进癌症转移,并且可能通过抑制血管紧张素 II 响应的细胞内钙动员来促进心脏肥大的进展。PTP4A3 蛋白, Human (His) 是重组的 PTP4A3 蛋白,由 E. coli 表达,带有 N-His 标签。PTP4A3 蛋白, Human (His) 全长 170 个氨基酸,分子量为 20.29 kDa。

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描述

PTP4A3 Protein, a tyrosine phosphatase, accelerates cell cycle progression from G1 to S phase, fostering cell proliferation, motility, and invasion. Its role extends to promoting cancer metastasis, and it may contribute to cardiac hypertrophy progression by inhibiting intracellular calcium mobilization in response to angiotensin II. PTP4A3 Protein, Human (His) is the recombinant human-derived PTP4A3 protein, expressed by E. coli , with N-His labeled tag. The total length of PTP4A3 Protein, Human (His) is 170 a.a., with molecular weight of 20.29 kDa.

研究背景

PTP4A3 蛋白是蛋白酪氨酸磷酸酶家族的成员,是细胞周期进程的关键调节因子,特别是促进有丝分裂期间从 G1 期向 S 期的转变。它的影响超出了细胞周期动力学,因为它积极增强细胞增殖、运动和侵袭行为,从而有助于促进癌症转移。此外,PTP4A3 似乎在心脏肥大的进展中发挥作用,可能是通过抑制血管紧张素 II 响应的细胞内钙动员来实现的。解开 PTP4A3 精心策划的复杂信号通路和分子机制对于全面了解其在细胞过程和病理条件中的不同作用至关重要。

种属

Human

表达系统

E. coli

标签

N-His

蛋白编号

O75365-1 (M1-C170)

基因 ID
蛋白结构
N-term
His
PTP4A3 (M1-C170)
Accession # O75365-1
C-term
同用名
PRL-R; PRLR; PRL-3; PRL3; PTP4A3;
分子量

20.29 kDa

纯度

Greater than 95% as determined by reducing SDS-PAGE.

内毒素含量

<1 EU/μg, determined by LAL method.

文件资料

PTP4A3 Protein, Human (His) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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产品名称:
PTP4A3 Protein, Human (His)
目录号:
HY-P701033
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