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  3. Enzymes & Regulators
  4. Hydrolases (EC 3)
  5. PTPN12 蛋白, Human

PTPN12 蛋白, Human

目录号: HY-P76557
产品使用指南

PTPN12 蛋白是一种多功能酶，可以使多种蛋白质去磷酸化，调节细胞信号级联。文献记载，PTPN12 选择性地靶向 ERBB2 和 PTK2B/PYK2 等酪氨酸激酶，对相关通路进行控制。值得注意的是，PTPN12 的特异性在特定酪氨酸残基（例如“Tyr-1112”、“Tyr-1196”和/或“Tyr-1248”）处对 ERBB2 进行去磷酸化方面很明显。其复杂的去磷酸化活性强调了 PTPN12 在调节酪氨酸激酶途径中的关键信号传导事件和微调细胞反应方面的重要性。PTPN12 蛋白, Human 是重组的 PTPN12 蛋白，由 Sf9 insect cells 表达，不带标签和 with residual Gly-Pro in N-terminal (not related to functional changes) 突变。PTPN12 蛋白, Human 全长 355 个氨基酸，分子量约为 ~41 kDa。

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100 μg   询价  

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描述

PTPN12 Protein, a versatile enzyme, dephosphorylates various proteins, regulating cellular signaling cascades. Documented in literature, PTPN12 selectively targets tyrosine kinases like ERBB2 and PTK2B/PYK2, exerting control over associated pathways. Notably, PTPN12's specificity is evident in dephosphorylating ERBB2 at specific tyrosine residues, such as 'Tyr-1112,' 'Tyr-1196,' and/or 'Tyr-1248.' Its intricate dephosphorylation activity underscores PTPN12's significance in modulating key signaling events and fine-tuning cellular responses within tyrosine kinase pathways. PTPN12 Protein, Human is the recombinant human-derived PTPN12 protein, expressed by Sf9 insect cells , with tag free. and with residual Gly-Pro in N-terminal (not related to functional changes) mutation. The total length of PTPN12 Protein, Human is 355 a.a., with molecular weight of ~41 kDa.
研究背景

正如文献中记载的那样，PTPN12 蛋白作为一种多功能酶，能够使一系列蛋白质去磷酸化，从而在各种细胞信号级联的调节中发挥着至关重要的作用。在其底物中，PTPN12 选择性地使细胞酪氨酸激酶（包括 ERBB2 和 PTK2B/PYK2）去磷酸化，对涉及这些激酶的信号通路发挥调节控制。 PTPN12 的特异性通过其在特定酪氨酸残基（例如“Tyr-1112”、“Tyr-1196”和/或“Tyr-1248”）处使 ERBB2 去磷酸化的能力而凸显。 PTPN12 复杂的去磷酸化活性强调了其在调节关键信号传导事件和微调酪氨酸激酶途径介导的细胞反应中的重要性。
种属

Human
表达系统

Sf9 insect cells
标签

Tag Free
蛋白编号

Q05209 (N-G&P, M1-Q355)
基因 ID
蛋白结构
N-term
Gly-Pro
PTPN12 (M1-Q355)
Accession # Q05209
C-term
同用名
Tyrosine-protein phosphatase non-receptor type 12; PTP-PEST; PTPG1
分子量

Approximately 41 kDa
纯度

Greater than 85% as determined by reducing SDS-PAGE
内毒素含量

<1 EU/μg, determined by LAL method.
文件资料
产品使用指南 (1213 KB)

PTPN12 Protein, Human 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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