PTPN12 - protein tyrosine phosphatase non-receptor type 12 Gene

中文名称：12 型蛋白酪氨酸磷酸酶非受体

种属: Homo sapiens

同用名: PTPG1; PTP-PEST

关于 PTPN12

功能概要

该基因编码的蛋白质是蛋白酪氨酸磷酸酶 (PTP) 家族的成员。 PTP 是调节多种细胞过程的信号分子，包括细胞生长、分化、有丝分裂周期和致癌转化。该 PTP 包含一个 C 端 PEST 基序，作为蛋白质-蛋白质相互作用结构域，可以调节蛋白质的细胞内半衰期。发现该 PTP 可结合致癌基因 c-ABL 的产物并使其去磷酸化，因此可能在肿瘤发生中发挥作用。该 PTP 还显示与细胞骨架结构和细胞粘附相关的各种产物相互作用并去磷酸化，例如 p130 (Cas) 、CAKbeta/PTK2B、PSTPIP1 和桩蛋白。这表明它在控制细胞形状和流动性方面具有调节作用。可变剪接导致编码不同异构体的多个转录变体。[RefSeq 提供，2008 年 10 月]

The protein encoded by this gene is a member of the protein tyrosine Phosphatase (PTP) family. PTPs are signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains a C-terminal PEST motif, which serves as a protein-protein interaction domain, and may regulate protein intracellular half-life. This PTP was found to bind and dephosphorylate the product of the oncogene c-ABL and thus may play a role in oncogenesis. This PTP was also shown to interact with, and dephosphorylate, various products related to cytoskeletal structure and cell adhesion, such as p130 (Cas), CAKbeta/PTK2B, PSTPIP1, and paxillin. This suggests it has a regulatory role in controlling cell shape and mobility. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Oct 2008]