S100P 蛋白, Human (His)

The S100P protein is a multifunctional calcium sensor that actively contributes to cellular calcium signaling. It interacts calcium-dependently with proteins such as EZR and PPP5C, indirectly affecting processes such as microvilli formation. S100P Protein, Human (His) is the recombinant human-derived S100P protein, expressed by E. coli , with N-6*His labeled tag. The total length of S100P Protein, Human (His) is 95 a.a., with molecular weight of ~12.0 kDa.

S100P 蛋白作为钙传感器发挥多方面的作用，积极促进细胞钙信号传导。它以钙依赖性方式与多种蛋白质（包括EZR和PPP5C）相互作用，从而间接参与上皮细胞微绒毛形成等生理过程。值得注意的是，S100P 可以通过自分泌激活活化糖基化终产物 (RAGE) 受体来刺激细胞增殖。S100P 作为同二聚体存在并与 S100A1 形成异二聚体，也与 S100PBP 和 S100Z 相互作用，并以钙依赖性方式与 CACYBP 结合。S100P 的二聚体形式通过揭示其 F-肌动蛋白结合位点来结合并激活 EZR/Ezrin，而其与 PPP5C 的钙依赖性相互作用可调节 PPP5C 活性，从而进一步了解 S100P 在细胞过程中的多种调节作用。

Human

E. coli

N-6*His

P25815 (M1-K95)

6286  [NCBI]

MTELETAMGMIIDVFSRYSGSEGSTQTLTKGELKVLMEKELPGFLQSGKDKDAVDKLLKDLDANGDAQVDFSEFIVFVAAITSACHKYFEKAGLK

Approximately 12.0 kDa

Greater than 90% as determined by reducing SDS-PAGE.

溶液.

Supplied as a 0.2 μm filtered solution of 20 mM Tris-HCl, 1 mM DTT, 0.1 M NaCl, 20% Glycerol, pH 8.0 .

<1 EU/μg, determined by LAL method.

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.