S100P - S100 calcium binding protein P Gene

中文名称：S100 钙结合蛋白 P

种属: Homo sapiens

同用名: MIG9

基因 ID: 6286 | 基因类型: protein coding

关于 S100P

Cytogenetic location: 4p16.1 Genomic coordinates (GRCh38): 4:6,693,878-6,697,170 (from NCBI)

This gene has 2 transcripts (splice variants), 131 orthologues and 21 paralogues. Biased expression in stomach (RPKM 580.8), bone marrow (RPKM 258.6) and 4 other tissues.

功能概要

由该基因编码的蛋白质是包含 2 个 EF 手钙结合基序的 S100 蛋白质家族的成员。 S100 蛋白定位于多种细胞的细胞质和/或细胞核，并参与许多细胞过程的调节，例如细胞周期进程和分化。 S100 基因包括至少 13 个成员，成簇位于染色体 1q21；然而，这个基因位于 4p16。这种蛋白质除了结合 Ca2+ 外，还结合 Zn2+ 和 Mg2+。这种蛋白质可能在前列腺癌的病因学中起作用。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21; however, this gene is located at 4p16. This protein, in addition to binding Ca2+, also binds Zn2+ and Mg2+. This protein may play a role in the etiology of prostate Cancer. [provided by RefSeq, Jul 2008]

S100P 基因产物(1)

mRNA	Protein	Name
NM_005980.3	NP_005971.1	protein S100-P

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables calcium-dependent protein binding	IPI IPI: 通过物理相互作用推断	15632002	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	11747429	GOA
enables protein homodimerization activity	IDA IDA: 通过直接分析推断	11747429	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in endothelial cell migration	IMP IMP: 通过突变表型推断	15313892	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in cytoplasm	IDA IDA: 通过直接分析推断	25468996	GOA
located in nucleus	IDA IDA: 通过直接分析推断	15632002	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

S100P 蛋白结构

S_100

0
95 a.a.

蛋白主名

其他名称

protein S100-P

migration-inducing gene 9 protein

重组 S100P 蛋白

目录号	产品名	蛋白编号	纯度
HY-P71138	S100P Protein, Human (His)	P25815 (M1-K95)	≥95%
HY-P71138A	S100P Protein, Human (N-His)	P25815 (T2-K95)	≥95%

关联疾病

疾病名称

别名

Classic Pulmonary Blastoma

Biphasic Pulmonary Blastoma

Endometrial Adenosquamous Carcinoma

Adenosquamous Carcinoma Of Endometrium	Adenosquamous Carcinoma Of The Endometrium
Endometrial Adenosquamous Cancer	Endometrial Adenosquamous Cell Carcinoma

Smarca4-Deficient Sarcoma Of Thorax

Smarca4-Dts

Smarca4-Deficient Thoracic Sarcoma

Prostate Cancer

Prostate Carcinoma	Prostate Cancer, Familial
Prostate Neoplasm	Prostate Cancer, Somatic
Prostate Cancer, Susceptibility To	Prostatic Cancer
Prostatic Neoplasms	Hereditary Prostate Cancer
Prostatic Neoplasm	Cancer Of Prostate
Carcinoma Of Prostate	Familial Prostate Cancer
Familial Prostate Carcinoma	Malignant Tumor Of Prostate
Malignant Neoplasm Of Prostate	Prostate Cancer, Familial, Susceptibility To
Malignant Tumor Of The Prostate	Ngp - New Growth Of Prostate
Tumor Of The Prostate	Prostate Cancer, Hereditary
Cancer Of The Prostate	Malignant Neoplasm Of The Prostate
Prostatic Carcinoma	PC
Prca	Cancer, Prostate
Malignant Prostatic Tumour	Malignant Tumour Of Prostate
Primary Prostate Cancer	Primary Malignant Neoplasm Of Prostate
Prostate Gland Cancer

Gastric Cancer

Stomach Cancer	Gastric Carcinoma
Stomach Carcinoma	Gastric Cancer, Somatic
Gastric Neoplasm	Carcinoma Of Stomach
Stomach Neoplasms	Malignant Neoplasm Of Stomach
Gastric Cancer Risk After H. Pylori Infection	Cancer Of The Stomach
Adult Stomach Cancer	Adult Stomach Carcinoma
GASC	Gastric Cancer Intestinal
Gastric Cancers	Gastric Carcinomas
Cancer, Gastric	Stomach Neoplasm
Malignant Neoplasm Of Body Of Stomach	Malignant Tumor Of Lesser Curve Of Stomach
Gastrocarcinoma Of Unspecified Site	Leather Bottle Stomach
Carcinoma Of Fundus Of Stomach	Cancer Of Fundus Of Stomach
Primary Malignant Neoplasm Of Body Of Stomach	Cancer Of Body Of Stomach
Primary Malignant Neoplasm Of Pyloric Antrum	Pyloric Antrum Cancer
Malignant Tumour Of Stomach

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-P2268A	RAGE antagonist peptide TFA	Antagonist	99.71%	否
HY-P2268	RAGE antagonist peptide	Antagonist	98.81%	否
HY-146695	S100P-IN-1	Inhibitor	99.74%	否
HY-RS12389	S100P Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

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