S100P 蛋白, Human (N-His)

The S100P protein is a multifunctional calcium sensor that actively contributes to cellular calcium signaling. It interacts calcium-dependently with proteins such as EZR and PPP5C, indirectly affecting processes such as microvilli formation. S100P Protein, Human (N-His) is the recombinant human-derived S100P protein, expressed by E. coli , with N-6*His labeled tag. The total length of S100P Protein, Human (N-His) is 94 a.a., with molecular weight of ~11.57 kDa.

S100P 蛋白作为钙传感器发挥多方面的作用，积极促进细胞钙信号传导。它以钙依赖性方式与多种蛋白质（包括EZR和PPP5C）相互作用，从而间接参与上皮细胞微绒毛形成等生理过程。值得注意的是，S100P 可以通过自分泌激活活化糖基化终产物 (RAGE) 受体来刺激细胞增殖。S100P 作为同二聚体存在并与 S100A1 形成异二聚体，也与 S100PBP 和 S100Z 相互作用，并以钙依赖性方式与 CACYBP 结合。S100P 的二聚体形式通过揭示其 F-肌动蛋白结合位点来结合并激活 EZR/Ezrin，而其与 PPP5C 的钙依赖性相互作用可调节 PPP5C 活性，从而进一步了解 S100P 在细胞过程中的多种调节作用。

Human

E. coli

N-6*His

P25815 (T2-K95)

6286  [NCBI]

TELETAMGMIIDVFSRYSGSEGSTQTLTKGELKVLMEKELPGFLQSGKDKDAVDKLLKDLDANGDAQVDFSEFIVFVAAITSACHKYFEKAGLK

Approximately 11.57 kDa

• 
  Greater than 95% as determined by reducing SDS-PAGE

无菌粉末.

Lyophilized from a 0.2 μm filtered solution of 20 mM PB,150 mM NaCl, pH 7.0.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.