Serpin B9 蛋白, Human (HEK293, His)

The Serpin B9 Protein, a member of the serpin family, crucially regulates immune responses by specifically inhibiting granzyme B, a protease involved in immune cell-mediated apoptosis. Acting as a potent inhibitor, Serpin B9 modulates granzyme B's cytotoxic activity, fine-tuning immune responses and preventing unwarranted cell death, emphasizing its significance in maintaining immune balance. Serpin B9 Protein, Human (HEK293, His) is the recombinant human-derived Serpin B9 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Serpin B9 Protein, Human (HEK293, His) is 376 a.a., with molecular weight of 35-40 kDa.

Serpin B9 蛋白作为颗粒酶 B 抑制剂，在调节免疫反应中发挥着至关重要的作用。作为丝氨酸蛋白酶抑制剂家族的一员，该蛋白特异性靶向并抑制颗粒酶 B（一种参与免疫细胞介导的细胞凋亡的蛋白酶）。作为一种有效的抑制剂，丝氨酸蛋白酶抑制剂 B9 可以调节颗粒酶 B 的细胞毒活性，从而影响免疫防御的关键过程并有助于免疫反应的微调。Serpin B9 的调节能力凸显了其在维持免疫平衡和防止颗粒酶 B 介导的不必要的细胞死亡方面的重要性。

Human

HEK293

C-6*His

P50453 (M1-P376)

5272  [NCBI]

METLSNASGTFAIRLLKILCQDNPSHNVFCSPVSISSALAMVLLGAKGNTATQMAQALSLNTEEDIHRAFQSLLTEVNKAGTQYLLRTANRLFGEKTCQFLSTFKESCLQFYHAELKELSFIRAAEESRKHINTWVSKKTEGKIEELLPGSSIDAETRLVLVNAIYFKGKWNEPFDETYTREMPFKINQEEQRPVQMMYQEATFKLAHVGEVRAQLLELPYARKELSLLVLLPDDGVELSTVEKSLTFEKLTAWTKPDCMKSTEVEVLLPKFKLQEDYDMESVLRHLGIVDAFQQGKADLSAMSAERDLCLSKFVHKSFVEVNEEGTEAAAASSCFVVAECCMESGPRFCADHPFLFFIRHNRANSILFCGRFSSP

35-40 kDa

Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末

Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.