SERPINB9 - serpin family B member 9 Gene

中文名称：serpin 家族 B 成员 9

种属: Homo sapiens

同用名: PI9; CAP3; PI-9; CAP-3

基因 ID: 5272 | 基因类型: protein coding

关于 SERPINB9

Cytogenetic location: 6p25.2 Genomic coordinates (GRCh38): 6:2,887,270-2,903,309 (from NCBI)

This gene has 1 transcript (splice variant), 150 orthologues and 36 paralogues. Broad expression in placenta (RPKM 26.1), appendix (RPKM 19.1) and 21 other tissues.

功能概要

该基因编码丝氨酸蛋白酶抑制剂家族的一个成员，也称为丝氨酸蛋白酶抑制剂。编码的蛋白质属于细胞内丝氨酸蛋白酶抑制蛋白的一个亚家族。这种蛋白质抑制效应分子颗粒酶 B 的活性。这种蛋白质的过度表达可能会阻止细胞毒性 T 淋巴细胞消除某些肿瘤细胞。在 6 号染色体上发现了该基因的假基因。[RefSeq 提供，2012 年 3 月]

This gene encodes a member of the Serine Protease Inhibitor family which are also known as serpins. The encoded protein belongs to a subfamily of intracellular serpins. This protein inhibits the activity of the effector molecule granzyme B. Overexpression of this protein may prevent cytotoxic T-lymphocytes from eliminating certain tumor cells. A pseudogene of this gene is found on chromosome 6. [provided by RefSeq, Mar 2012]

SERPINB9 基因产物(1)

mRNA	Protein	Name
NM_004155.6	NP_004146.1	serpin B9

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process	IDA IDA: 通过直接分析推断	10790428	GOA
enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process	IMP IMP: 通过突变表型推断	17479112	GOA
enables protease binding	IPI IPI: 通过物理相互作用推断	16267761	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	17479112	GOA
enables serine-type endopeptidase inhibitor activity	IDA IDA: 通过直接分析推断	8910377	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in cellular response to estrogen stimulus	IEP IEP: 通过表达模式推断	17237823	GOA
involved in immune response	IDA IDA: 通过直接分析推断	16306080	GOA
involved in mast cell mediated immunity	IEP IEP: 通过表达模式推断	15739160	GOA
involved in negative regulation of apoptotic process	IMP IMP: 通过突变表型推断	17237823	GOA
involved in negative regulation of endopeptidase activity	IMP IMP: 通过突变表型推断	21795594	GOA
involved in protection from natural killer cell mediated cytotoxicity	IMP IMP: 通过突变表型推断	21795594	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in cytoplasm	IDA IDA: 通过直接分析推断	11463822	GOA
located in cytosol	IDA IDA: 通过直接分析推断	11485349	GOA
located in extracellular space	IDA IDA: 通过直接分析推断	16267761	GOA
located in nucleus	IDA IDA: 通过直接分析推断	11463822	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SERPINB9 蛋白结构

Serpin

0
100
200
300
376 a.a.

蛋白主名

其他名称

serpin B9

cytoplasmic antiproteinase 3

SERPINB9 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	SERPINB9	P50453	TRAF5	Homo sapiens	O00463	Y2H Prey Pooling	25416956
种属内	SERPINB9	P50453	TRAF5	Homo sapiens	O00463	Y2H Prey Pooling	32296183
种属内	SERPINB9	P50453	TRAF5	Homo sapiens	O00463	Y2H Array	32296183
种属内	SERPINB9	P50453	ST3GAL3	Homo sapiens	Q11203	Anti Tag CoIP	33961781

种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 SERPINB9 蛋白

目录号	产品名	蛋白编号	纯度
HY-P71306	Serpin B9 Protein, Human (HEK293, His)	P50453 (M1-P376)	≥95%

关联疾病

疾病名称

别名

Pituitary Adenoma 2, Growth Hormone-Secreting

PITA2	Acromegaly Due To Pituitary Adenoma 2
Acromegaly, X-Linked	Growth Hormone Secreting Pituitary Adenoma 2
Pituitary Adenoma, Growth Hormone-Secreting, 2	Pituitary Adenoma 2, Gh-Secreting
Gh-Secreting Pituitary Adenoma 2	X-Linked Acromegaly
Adenoma, Pituitary, Growth Hormone-Secreting, Type 2

Patella, Chondromalacia Of

Chondromalacia Patellae	Chondromalacia Of Patella
Softening Of Articular Cartilage Of Patella	Patellofemoral Pain Syndrome
Patellofemoral Chondromalacia

Palmoplantar Keratoderma And Congenital Alopecia 2

Cataract-Alopecia-Sclerodactyly Syndrome	Cass
Autosomal Recessive Palmoplantar Keratoderma And Congenital Alopecia	PPKCA2
Autosomal Recessive Palmoplantar Hyperkeratosis And Congenital Alopecia	Palmoplantar Keratoderma And Congenital Alopecia, Wallis Type
Ppk-Ca, Wallis Type	Cataract, Alopecia, Sclerodactyly
Ppkca, Wallis Type	Ppkca Wallis Type
Cataract, Alopecia, Sclerodactyly Syndrome

Childhood Central Nervous System Primitive Neuroectodermal Neoplasm

Pediatric Cns Pnet

Childhood Central Nervous System Primitive Neuroectodermal Tumor

Severe Congenital Neutropenia 7

Autosomal Recessive Severe Congenital Neutropenia Due To Csf3r Deficiency

Scn7

Reticulosarcoma

Histiocytic Lymphoma	Large-Cell Lymphomas
Lymphoma, Large-Cell	Lymphoma Large Cell
Diffuse Large B-Cell Lymphoma	Histiocytic Sarcoma

Ewing Sarcoma

Neuroepithelioma	Ewing'S Tumor
Primitive Neuroectodermal Tumor	Ewings Sarcoma
Ewing'S Sarcoma	Peripheral Neuroepithelioma
ES	Ewings Sarcoma-Primitive Neuroectodermal Tumor
Localized Peripheral Primitive Neuroectodermal Tumor	Peripheral Primitive Neuroectodermal Tumor
Ewing Tumor	Sarcoma, Ewing'S
Ewing Family Of Tumors	Extraosseous Ewing Tumor
Askin Tumor	Ewing'S Family Localized Tumor
Ewing'S Sarcoma/Peripheral Primitive Neuroectodermal Tumor	Localized Ewing Sarcoma
Localized Ewing'S Sarcoma	Localized Ewing'S Sarcoma/Peripheral Primitive Neuroectodermal Tumor
Localized Ewing'S Tumor	Pnet Of Thoracopulmonary Region
Tumor Of The Ewing Family	Skeletal Ewing Sarcoma
Osseous Ewing Sarcoma	Ppnet
Peripheral Pnet	Extraskeletal Ewing Sarcoma
Eoe	Extraosseous Ewing Sarcoma
Extraskeletal Ewing Tumor	Esft
Ewing Sarcoma Family Of Tumors	Pne
Pnet	Pnet Of The Chest Wall
Sarcoma, Ewing	Neuroectodermal Tumors, Primitive, Peripheral
Neuroectodermal Tumor, Primitive	Disorder Of Eye
Askin'S Tumor	Extraosseous Ewings Sarcoma-Primitive Neuroepithelial Tumor
Neuroepithelioma, Peripheral

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS12717	SERPINB9 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Canis familiaris	SERPINB9	VGNC	VGNC:46033
Felis catus	SERPINB9	VGNC	VGNC:68840
Macaca mulatta	SERPINB9	VGNC	VGNC:77371
Rattus norvegicus	SERPINB9	RGD	RGD:1549730
Bos taurus	SERPINB9	VGNC	VGNC:54235

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站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

SERPINB9 - serpin family B member 9 Gene

关于 SERPINB9

功能概要

SERPINB9 基因产物(1)

SERPINB9 蛋白结构

SERPINB9 蛋白互作信息

重组 SERPINB9 蛋白

关联疾病

直系同源

热门区域

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SERPINB9 - serpin family B member 9 Gene

关于 SERPINB9

功能概要

SERPINB9 基因产物(1)

SERPINB9 蛋白结构

SERPINB9 蛋白互作信息

重组 SERPINB9 蛋白

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z