SLP-76 蛋白, Human (His-T7)

The SLP-76 protein is critical in T cell antigen receptor-mediated signaling and participates in multiple molecular interactions. Its association with SLA coordinates T cell signaling, whereas its interaction with CBLB emphasizes regulatory effects. SLP-76 Protein, Human (His-T7) is the recombinant human-derived SLP-76 protein, expressed by E. coli , with N-T7, C-6*His labeled tag. The total length of SLP-76 Protein, Human (His-T7) is 533 a.a., with molecular weight of ~70.0 kDa.

SLP-76 蛋白是 T 细胞抗原受体介导的信号传导的关键参与者，复杂地参与各种分子相互作用。值得注意的是，它与 SLA 相互作用，有助于协调 T 细胞信号传导事件。它与 CBLB 的联系强调了它对监管流程的参与。此外，SLP-76 与 GRB2 和 SHB 等信号蛋白发生重要的相互作用，凸显了其在信号转导级联中的作用。此外，SLP-76 与 PRAM1 形成复合物，有助于形成 T 细胞信号通路内复杂的蛋白质相互作用网络。SLP-76 和 CD6 之间的结合，特别是与 CD6 酪氨酸磷酸化 C 末端的结合，进一步强调了其在介导细胞反应中的重要性。此外，SLP-76 与 FYB1 和 FYB2 的磷酸化形式相互作用，使其在 T 细胞信号传导中的调节功能又增加了一层复杂性。

Human

E. coli

N-T7;C-6*His

Q13094 (M1-P533)

3937  [NCBI]

MALRNVPFRSEVLGWDPDSLADYFKKLNYKDCEKAVKKYHIDGARFLNLTENDIQKFPKLRVPILSKLSQEINKNEERRSIFTRKPQVPRFPEETESHEEDNGGWSSFEEDDYESPNDDQDGEDDGDYESPNEEEEAPVEDDADYEPPPSNDEEALQNSILPAKPFPNSNSMYIDRPPSGKTPQQPPVPPQRPMAALPPPPAGRNHSPLPPPQTNHEEPSRSRNHKTAKLPAPSIDRSTKPPLDRSLAPFDREPFTLGKKPPFSDKPSIPAGRSLGEHLPKIQKPPLPPTTERHERSSPLPGKKPPVPKHGWGPDRRENDEDDVHQRPLPQPALLPMSSNTFPSRSTKPSPMNPLPSSHMPGAFSESNSSFPQSASLPPYFSQGPSNRPPIRAEGRNFPLPLPNKPRPPSPAEEENSLNEEWYVSYITRPEAEAALRKINQDGTFLVRDSSKKTTTNPYVLMVLYKDKVYNIQIRYQKESQVYLLGTGLRGKEDFLSVSDIIDYFRKMPLLLIDGKNRGSRYQCTLTHAAGYP

Approximately 70.0 kDa

Greater than 90% as determined by reducing SDS-PAGE.

溶液.

Supplied as a 0.2 μm filtered solution of 20 mM Tris-HCl, 200 mM NaCl, 20% Glycerol, pH 8.5.

<1 EU/μg, determined by LAL method.

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.