2. Gene
  3. LCP2 - lymphocyte cytosolic protein 2 Gene

LCP2 - lymphocyte cytosolic protein 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：淋巴细胞胞质蛋白 2

种属: Homo sapiens

同用名: IMD81; SLP76; SLP-76

基因 ID: 3937 | 基因类型: protein coding

关于 LCP2

Cytogenetic location: 5q35.1 Genomic coordinates (GRCh38): 5:170,246,233-170,297,777 (from NCBI)

This gene has 9 transcripts (splice variants), 232 orthologues, 3 paralogues and is associated with 1 phenotype. Broad expression in bone marrow (RPKM 53.7), appendix (RPKM 44.7) and 19 other tissues.

功能概要

该基因编码一种衔接蛋白，作为 T 细胞抗原受体 (TCR) 激活蛋白酪氨酸激酶通路的底物。编码的蛋白质与生长因子受体结合蛋白 2 结合，被认为在 TCR 介导的细胞内信号转导中起作用。小鼠中的一种类似蛋白质在正常 T 细胞发育和激活中发挥作用。缺乏该基因的小鼠会出现皮下和腹腔内胎儿出血、血小板功能障碍和生存能力受损。[RefSeq 提供，2016 年 11 月]

This gene encodes an adapter protein that acts as a substrate of the T cell antigen receptor (TCR)-activated protein tyrosine kinase pathway. The encoded protein associates with growth factor receptor bound protein 2, and is thought to play a role TCR-mediated intracellular signal transduction. A similar protein in mouse plays a role in normal T-cell development and activation. Mice lacking this gene show subcutaneous and intraperitoneal fetal hemorrhaging, dysfunctional platelets and impaired viability. [provided by RefSeq, Nov 2016]

LCP2 基因产物(1)

mRNA Protein Name
NM_005565.5 NP_005556.1 lymphocyte cytosolic protein 2

LCP2 蛋白结构

SAM_2

SAM_2: SAM domain (Sterile alpha motif) (13 - 75)

SH2

SH2: SH2 domain (422 - 505)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 533 a.a.
蛋白主名 其他名称

lymphocyte cytosolic protein 2

76 kDa tyrosine phosphoprotein

重组 LCP2 蛋白

目录号 产品名 蛋白编号 纯度
HY-P71320 SLP-76 Protein, Human (His-T7) Q13094 (M1-P533) ≥95%

关联疾病

疾病名称 别名
Immunodeficiency 81

IMD81
Wiskott-Aldrich Syndrome

WAS

Eczema-Thrombocytopenia-Immunodeficiency Syndrome

Immunodeficiency 2

Aldrich Syndrome

Imd2

Wiskott-Aldrich Syndrome 1

Was1

Wiskott Syndrome

Wiskott Aldrich Syndrome

Eczema Thrombocytopenia Immunodeficiency Syndrome

Imd 2
Agammaglobulinemia 4, Autosomal Recessive

Agammaglobulinemia 4

AGM4

Agammaglobulinemia, Autosomal Recessive, Due To Blnk Defect

B Cell Linker Protein Deficiency

B-Cell Linker Protein Deficiency

Blnk Deficiency

Agammaglobulinemia Autosomal Recessive Due To Blnk Defect

Agammaglobulinemia, Type 4, Autosomal Recessive
Combined Immunodeficiency

Combined T Cell And B Cell Immunodeficiency

Congenital Combined Immunodeficiency

Syndrome With Combined Immunodeficiency

Combined T And B Cell Immunodeficiency

Combined Immunity Deficiency

Combined Immunodeficiency Syndrome

Combined T-Cell And B-Cell Immunodeficiency

Lymphopenic Agammaglobulinaemia
Severe Combined Immunodeficiency

Scid

Severe Combined Immunodeficiency Disease

Combined T And B Cell Inborn Immunodeficiency

Immunodeficiency, Severe Combined

Scid - [Severe Combined Immunodeficiencies]
Hemolytic Anemia

Anemia, Hemolytic

Anemia Hemolytic

Anaemia Due To Other Disorders Of Glutathione Metabolism

Chronic Non Spherocytic Anaemia

G6pd - [Glucose-6-Phosphate Dehydrogenase Deficiency] Anaemia

Anaemia Due To Glucose-6-Phosphate Dehydrogenase Deficiency

Glucose-6-Phosphate Dehydrogenase Deficiency With Anaemia

Glucose-6-Phosphate Dehydrogenase Deficiency Anaemia

Favism Anaemia

Haemolytic Anaemia Due Tog6pd Deficiency

Favism

Pentose Phosphate Pathway Disorder Anaemia

Anaemia Due To Pentose Phosphate Pathway Defect
T-Cell Acute Lymphoblastic Leukemia

T-Cell Leukemia

Acute T Cell Leukemia

Precursor T Lymphoblastic Leukemia

Precursor T-Lymphoblastic Lymphoma/Leukemia

T Acute Lymphoblastic Leukemia

T-Cell Acute Lymphocytic Leukaemia

T-Cell Lymphoblastic Leukemia/Lymphoma

Leukemia T-Cell

Leukemia, T-Cell

Leukemia, Acute, Lymphoblastic, T-Cell

Leukemia, T-Cell Acute Lymphoblastic

Leukemia, Acute T-Cell

Precursor T-Cell Lymphoblastic Leukemia-Lymphoma

Precursor T-Cell Lymphoblastic Lymphoma

Precursor T Cell Lymphoblastic Leukemia/Lymphoblastic Lymphoma
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS07564 LCP2 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris LCP2 VGNC VGNC:42615
Felis catus LCP2 VGNC VGNC:68025
Bos taurus LCP2 VGNC VGNC:30818
Rattus norvegicus LCP2 RGD RGD:619743
Mus musculus LCP2 MGD MGI:1321402
Macaca mulatta LCP2 VGNC VGNC:74243
Others LCP2 NCBI
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