FYB1 - FYN binding protein 1 Gene

中文名称：FYN 结合蛋白 1

种属: Homo sapiens

同用名: FYB; ADAP; THC3; PRO0823; SLAP130; SLAP-130

基因 ID: 2533 | 基因类型: protein coding

关于 FYB1

Cytogenetic location: 5p13.1 Genomic coordinates (GRCh38): 5:39,105,252-39,274,528 (from NCBI)

This gene has 14 transcripts (splice variants), 203 orthologues, 2 paralogues and is associated with 2 phenotypes. Broad expression in appendix (RPKM 36.5), lymph node (RPKM 32.7) and 15 other tissues.

功能概要

该基因编码的蛋白质是 T 细胞中 Fyn 蛋白和 LCP2 信号级联的衔接子。编码的蛋白质参与血小板活化并控制白介素 2 的表达。已发现该基因的三个转录变体编码不同的亚型。[RefSeq 提供，2011 年 7 月]

The protein encoded by this gene is an adapter for the Fyn protein and LCP2 signaling cascades in T-cells. The encoded protein is involved in platelet activation and controls the expression of interleukin-2. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011]

FYB1 基因产物(5)

mRNA	Protein	Name
NM_001243093.2	NP_001230022.1	FYN-binding protein 1 isoform 3
NM_001349333.2	NP_001336262.1	FYN-binding protein 1 isoform 1
NM_001465.6	NP_001456.3	FYN-binding protein 1 isoform 1
NM_018594.2	NP_061064.2	FYN-binding protein 1 isoform 4
NM_199335.5	NP_955367.1	FYN-binding protein 1 isoform 2

基因本体论

分子功能

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	10409671	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

FYB1 蛋白结构

SH3_2

hSH3

0
200
400
600
783 a.a.

蛋白主名

其他名称

FYN-binding protein 1

FYB-120/130

FYB1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Intra	FYB1	O15117	SKAP1	Homo sapiens	Q86WV1	Anti Bait CoIP	16461356
Intra	FYB1	O15117	SKAP1	Homo sapiens	Q86WV1	Far-WB	16461356
Intra	FYB1	O15117	SKAP1	Homo sapiens	Q86WV1	SPR	16461356
Intra	FYB1	O15117	SKAP1	Homo sapiens	Q86WV1	TAP	19798671
Intra	FYB1	O15117	LCP2	Homo sapiens	Q13094	CoIP	9207119
Intra	FYB1	O15117	LCP2	Homo sapiens	Q13094	Pull Down	22074159
Intra	FYB1	O15117	LCP2	Homo sapiens	Q13094	CoIP	10570256
Intra	FYB1	O15117	NCK1	Homo sapiens	P16333	Pull Down	22074159
Intra	FYB1	O15117	NCK2	Homo sapiens	O43639	Pull Down	22074159

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Thrombocytopenia 3

THC3	Thrombocytopenia, Autosomal Recessive, 3

Congenital Autosomal Recessive Small-Platelet Thrombocytopenia

Carst

Plasmodium Vivax Malaria

Malaria, Vivax	Malaria By Plasmodium Vivax
Vivax Malaria	Malaria Vivax

Thrombocytopenia

Low Platelet Count	Low Platelets
Decreased Platelets	Platelet Dysfunction Nos

Blood Group Incompatibility

Rh Isoimmunization

Rh Incompatibility Affecting Management Of Mother

Factor Xi Deficiency

Plasma Thromboplastin Antecedent Deficiency	Rosenthal Syndrome
Pta Deficiency	Hemophilia C
Rosenthal Factor Deficiency	F11 Deficiency
Congenital Factor Xi Deficiency	Hereditary Factor Xi Deficiency Disease
Haemophilia C	Factor Xi Deficiency, Autosomal Dominant
Rosenthal'S Disease	Factor 11 Deficiency
Factor Xi	Factor Xi Deficiency, Autosomal Recessive
Factor Xi Deficiency, Congenital	FA11D
Thromboplastin Antecedent Deficiency	Pta - [Plasma Thromboplastin Antecedent] Deficiency
Congenital Factor Xi Deficiency Disease	Rosenthal Disease

Hemoglobinopathy

Hemoglobinopathies

Glucosephosphate Dehydrogenase Deficiency

G6pd Deficiency	Glucose-6-Phosphate Dehydrogenase Deficiency
Deficiency Of Glucose-6-Phosphate Dehydrogenase	Glucose 6 Phosphate Dehydrogenase Deficiency
Deficiency Of G-6pd	G6pdd

Sickle Cell Anemia

Hemoglobin Sc Disease	Anemia, Sickle Cell
Hbsc Disease	Sickle Cell-Hemoglobin C Disease Syndrome
Hb Ss Disease	Sickle Cell Trait
Drepanocytosis	Haemoglobin Sc Disease
Hb Sc Disease	Hb-S/Hb-C Disease
Hb-Ss Disease Without Crisis	Hemoglobin S Disease Without Crisis
Sickle Cell Anaemia	Sickle-Cell/Hb-C Disease Without Crisis
Sickle Cell - Hemoglobin C Disease	Hbs Disease
Hemoglobin S Disease	Sickling Disorder Due To Hemoglobin S
SKCA	Sickle Cell Disease
Sickle Cell-Hemoglobin C Disease	Sickle-Cell Disease Carrier
Sickle-Cell Heterozygous Disorder	Haemoglobin A-S Genotype
Hb-S - [Sickle Cell Haemoglobin] Carrier	Sickle Cell Haemoglobin Trait
As - [Sickle Cell Trait]	Hbas - [Sickle Cell Haemoglobin Trait]
Sickle-Cell Trait Haemoglobin Disease	Haemoglobin Sickle Cell Trait Disorder
Heterozygous Sickle Cell Trait	Hbas - [Heterozygous Haemoglobin S]

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS05172	FYB1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Macaca mulatta	FYB1	VGNC	VGNC:72831
Canis familiaris	FYB1	VGNC	VGNC:41024
Bos taurus	FYB1	VGNC	VGNC:29160
Mus musculus	FYB1	MGD	MGI:1346327
Felis catus	FYB1	VGNC	VGNC:62398
Rattus norvegicus	FYB1	RGD	RGD:1563421

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

FYB1 - FYN binding protein 1 Gene

关于 FYB1

功能概要

FYB1 基因产物(5)

FYB1 蛋白结构

FYB1 蛋白互作信息

关联疾病

直系同源

热门区域

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FYB1 - FYN binding protein 1 Gene

关于 FYB1

功能概要

FYB1 基因产物(5)

FYB1 蛋白结构

FYB1 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z