SNAP25 蛋白, Human (His)

SNAP25 is a key t-SNARE in neurotransmitter release, regulating synaptic function and plasma membrane recycling. It cooperates with CENPF to affect vesicle docking and membrane fusion. SNAP25 Protein, Human (His) is the recombinant human-derived SNAP25 protein, expressed by E. coli , with N-His labeled tag. The total length of SNAP25 Protein, Human (His) is 206 a.a., with molecular weight of ~28 kDa.

SNAP25 是神经递质释放分子编排中不可或缺的 t-SNARE，在特定神经元系统内的突触功能中发挥着关键作用。SNAP25 与参与囊泡对接和膜融合的蛋白质形成关联，通过与 CENPF 相互作用复杂地调节质膜回收。其调节影响延伸至胰腺 β 细胞中延迟整流器电压依赖性钾通道 KCNB1 的门控特性。作为由 SNAP25、VAMP2 和 STX1A 组成的 SNARE 核心复合体的一部分，它构成了复杂神经递质释放的基本催化机制。STX1A 与 STXBP1 的结合促进了 SNARE 复合体的招募。此外，SNAP25 参与涉及 SYT1、SV2B、syntaxin-1、CPLX1 和 BLOC1S6 的多种复合体。与 HSC70、SYT9、DNAJC5、CENPF、EQTN、HGS、KCNB1、OTOF、RIMS1、SNAPIN、STXBP6、TRIM9、ZDHHC13、ZDHHC17、PLCL1、PRRT2、SNCA、PRPH2、ROM1 和 STX3 的相互作用进一步强调了其复杂的分子参与，突出它对细胞过程和信号通路的多方面贡献。

Human

E. coli

N-His

P60880 (M1-G206)

6616  [NCBI]

Approximately 28 kDa

Greater than 90% as determined by reducing SDS-PAGE.

溶液.

Supplied as a 0.2 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

N/A.

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.