SR-BI/SCARB1 蛋白, Human (HEK293, His-Fc)

The SR-BI/SCARB1 protein is a multifunctional receptor that binds a variety of ligands, including phospholipids, cholesteryl esters, lipoproteins, phosphatidylserine, and apoptotic cells. As an HDL receptor, it crucially mediates selective cholesterol ether uptake and HDL-dependent cholesterol efflux. SR-BI/SCARB1 Protein, Human (HEK293, His-Fc) is the recombinant human-derived SR-BI/SCARB1 protein, expressed by HEK293 , with C-hFc, C-His labeled tag.

SR-BI/SCARB1 蛋白作为一种多功能受体，可与多种配体结合，包括磷脂、胆固醇酯、脂蛋白、磷脂酰丝氨酸和凋亡细胞。作为 HDL 受体，它在胆固醇醚的选择性摄取和 HDL 依赖性胆固醇流出中发挥着至关重要的作用。此外，SR-BI 促进细胞表面和含有 apoB 的脂蛋白之间游离和酯化胆固醇的交换，尽管效率低于 HDL。它通过磷脂酰丝氨酸结合活性介导参与凋亡细胞的吞噬作用，为其功能库增添了另一层。在微生物感染的情况下，SR-BI 在肝细胞中充当丙型肝炎病毒的受体，促进其进入细胞，而与病毒分离株基因型无关。不同的配体相互作用以及在胆固醇稳态、凋亡细胞清除和病毒感染中的作用凸显了 SR-BI/SCARB1 作为细胞过程中的多功能参与者。

Human

HEK293

C-10*His;C-hFc

Q8WTV0-1/NP_001076428.1 (P33-Y443)

949  [NCBI]

PSLIKQQVLKNVRIDPSSLSFNMWKEIPIPFYLSVYFFDVMNPSEILKGEKPQVRERGPYVYREFRHKSNITFNNNDTVSFLEYRTFQFQPSKSHGSESDYIVMPNILVLGAAVMMENKPMTLKLIMTLAFTTLGERAFMNRTVGEIMWGYKDPLVNLINKYFPGMFPFKDKFGLFAELNNSDSGLFTVFTGVQNISRIHLVDKWNGLSKVDFWHSDQCNMINGTSGQMWPPFMTPESSLEFYSPEACRSMKLMYKESGVFEGIPTYRFVAPKTLFANGSIYPPNEGFCPCLESGIQNVSTCRFSAPLFLSHPHFLNADPVLAEAVTGLHPNQEAHSLFLDIHPVTGIPMNCSVKLQLSLYMKSVAGIGQTGKIEPVVLPLLWFAESGAMEGETLHTFYTQLVLMPKVMHY

Approximately 100-120 kDa due to the glycosylation.

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  Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4, 5% trehalose, 5% mannitol and 0.01% Tween80.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.