STAT4 蛋白, Human (sf9, His)

The STAT4 protein is mainly expressed in hematopoietic cells and is critical for cell growth, differentiation and immune responses. It plays a key role in T helper 1 cell differentiation, interferon gamma production, and various neutrophil activities. STAT4 Protein, Human (sf9, His) is the recombinant human-derived STAT4 protein, expressed by Sf9 insect cells , with N-His labeled tag. The total length of STAT4 Protein, Human (sf9, His) is 748 a.a., with molecular weight of ~87 kDa.

STAT4 是一种主要在造血细胞中表达的转录调节因子，在细胞生长、分化和免疫反应中发挥着至关重要的作用。它特别参与 T 辅助细胞 1 细胞的分化和干扰素 γ 的产生，显示出其在协调免疫功能中的重要性。STAT4 参与多种中性粒细胞活动，包括趋化性和中性粒细胞胞外陷阱的产生，进一步强调了其多功能作用。IL12 与 IL12RB2 结合后，STAT4 发生酪氨酸磷酸化，导致同二聚化和核转位。虽然 IL12 是主要激活信号，但 STAT4 也可以响应 IFN-γ、IL23、IL2 和 IL35 而被激活。在 IFN-α/β 信号传导背景下，STAT4 充当转录抑制因子，在 T 细胞受体激活过程中抑制 IL5 和 IL13 mRNA 表达。这种多方面的调节蛋白与相关家族成员形成同二聚体或异二聚体，并与各种伙伴相互作用，包括 ARL2BP、IL12RB2、STAT1 和 JUN，从而在免疫调节中发挥复杂的作用。

Human

Sf9 insect cells

N-His

Q14765 (M1-E748)

6775  [NCBI]

Approximately 87 kDa

Greater than 95% as determined by reducing SDS-PAGE

溶液

Supplied as a 0.2 μm filtered solution of 20 mM Tris, 500 mM NaCl, pH 7.4, 20% glycerol, 0.5 mM DTT.

<1 EU/μg, determined by LAL method.

N/A.

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.