1. Gene
  2. STAT4 - signal transducer and activator of transcription 4 Gene

STAT4 - signal transducer and activator of transcription 4 Gene

中文名称:信号转导和转录激活因子 4

种属: Homo sapiens

同用名: SLEB11

基因 ID: 6775 | 基因类型: protein coding

关于 STAT4

Cytogenetic location: 2q32.2-q32.3 Genomic coordinates (GRCh38): 2:191,029,576-191,246,175 (from NCBI)

This gene has 11 transcripts (splice variants), 199 orthologues, 6 paralogues and is associated with 6 phenotypes. Broad expression in testis (RPKM 9.8), lymph node (RPKM 6.0) and 17 other tissues.

功能概要

该基因编码的蛋白质是 STAT 转录因子家族的成员。响应于细胞因子和生长因子,STAT 家族成员被受体相关激酶磷酸化,然后形成同二聚体或异二聚体,转移到细胞核,在那里它们充当转录激活剂。这种蛋白质对于介导淋巴细胞对 IL12 的反应以及调节 T 辅助细胞的分化至关重要。该基因的突变可能与系统性红斑狼疮和类风湿性关节炎有关。交替剪接导致编码相同蛋白质的多个转录变体。[RefSeq 提供,2011 年 8 月]

The protein encoded by this gene is a member of the STAT family of transcription factors. In response to Cytokines and Growth Factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is essential for mediating responses to IL12 in lymphocytes, and regulating the differentiation of T helper cells. Mutations in this gene may be associated with systemic lupus erythematosus and rheumatoid arthritis. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Aug 2011]

STAT4 基因产物(2)

mRNA Protein Name
NM_001243835.2 NP_001230764.1 signal transducer and activator of transcription 4
NM_003151.4 NP_003142.1 signal transducer and activator of transcription 4

STAT4 蛋白结构

STAT_int

STAT_int: STAT protein, protein interaction domain (2 - 121)

STAT_alpha

STAT_alpha: STAT protein, all-alpha domain (137 - 314)

STAT_bind

STAT_bind: STAT protein, DNA binding domain (316 - 563)

SH2

SH2: SH2 domain (573 - 627)

  • 0
  • 200
  • 400
  • 600
  • 748 a.a.
蛋白主名 其他名称

signal transducer and activator of transcription 4

重组 STAT4 蛋白

目录号 产品名 蛋白编号 纯度
HY-P76664 STAT4 Protein, Human (sf9, His) Q14765 (M1-E748) ≥95%

关联疾病

疾病名称 别名
Systemic Lupus Erythematosus 11

Systemic Lupus Erythematosus, Susceptibility To, 11

SLEB11

Lupus Erythematosus, Systemic, Type 11

Systemic Lupus Erythematosus

Lupus Nephritis

SLE

Disseminated Lupus Erythematosus

Systemic Lupus Erythematosus, Susceptibility To

Lupus Erythematosus, Systemic

Lupus Nephritis, Susceptibility To

Libman-Sacks Disease

Systemic Lupus Erythematosus Susceptibility To

Sle - Lupus Erythematosus, Systemic

Le Syndrome

Lupus

Lupus Erythematosus Systemic

Lupus Erythematosus, Systemic, Susceptibility To

Lupus Vulgaris

Lupus Erythematosus, Discoid

Lupus Erythematosus

Systemic Lupus Erythematosus Nos

Sle - [Systemic Lupus Erythematosus]

Arthritis

Inflammatory Joint Disease

Inflammatory Disorder Of Joint

Lupus Erythematosus

Lupus

Lupus Vulgaris

Lupus Erythematosus, Discoid

Lupus Erythematosus, Systemic

Subacute Cutaneous Lupus

Le - [Lupus Erythematosus]

Pediatric Systemic Lupus Erythematosus

Sle, Pediatric Onset

Rheumatoid Arthritis

RA

Arthritis, Rheumatoid

Rheumatoid Arthritis, Susceptibility To

Arthritis Or Polyarthritis, Rheumatic

Atrophic Arthritis

Rheumatism Arthritis

Rheumatoid Polyarthritis

Oligoarticular Juvenile Idiopathic Arthritis

Oligoarticular Jia

Pauciarticular Chronic Arthritis

Juvenile Pauciarticular Chronic Arthritis

Rheumatoid Factor-Negative Polyarticular Juvenile Idiopathic Arthritis

Juvenile Polyarthritis Without Rheumatoid Factor

Juvenile Rheumatoid Factor-Negative Polyarthritis

Rheumatoid Factor-Negative Polyarticular Jia

Polyarticular Juvenile Idiopathic Arthritis, Rheumatoid Factor Negative

Behcet Syndrome

Behcet Disease

Behcet'S Syndrome

Behcet'S Disease

Behçet Disease

Bd

Adamantiades-Behcet Disease

Triple Symptom Complex

Behçet'S Disease

Behet'S Syndrome

Bd Syndrome

Behçet Syndrome

Behçet'S Syndrome

Behcet Triple Symptom Complex

Malignant Aphthosis

Old Silk Route Disease

Adamantiades-Behçet Disease

Inflammatory Bowel Disease

Inflammatory Bowel Diseases

Bowel Disease, Inflammatory

Autoimmune Disease

Autoimmune Diseases

Autoimmune Hypersensitivity Disease

Hypersensitivity Reaction Type Ii Disease

Type Ii Hypersensitivity Reaction Disease

Hepatitis B

Chronic Hepatitis B

Hepatitis B Infection

Serum Hepatitis

HBV

Hepatitis B Chronic

Hbv, Susceptibility To

Hepatitis B, Chronic

Chronic Hepatitis B Without Delta Agent

Chronic Hbv - [Hepatitis B Virus] Infection

Hepatitis B Nos

Chronic Type B Viral Hepatitis

Hep B Nos

Sezary'S Disease

Sezary Syndrome

Sézary Syndrome

Sezary'S Lymphoma

Sezary Disease

Sezary Erythroderma

Sezary Lymphoma

Systemic Scleroderma

Scleroderma

Progressive Systemic Sclerosis

Systemic Sclerosis

Scleroderma, Systemic

Scleroderma Syndrome

Dermatosclerosis

Familial Progressive Scleroderma

Progressive Scleroderma

Scleroderma Disease

Scleroderma, Localized

Diffuse Scleroderma

Scleroderma, Familial Progressive

Leukodystrophy, Hypomyelinating, 8, With Or Without Oligodontia And/Or Hypogonadotropic Hypogonadism

Hypomyelinating Leukodystrophy 8 With Or Without Oligodontia And-Or Hypogonadotropic Hypogonadism

HLD8

Cerebellar Hypoplasia With Endosteal Sclerosis

4h Leukodystrophy 2

Endosteal Sclerosis-Cerebellar Hypoplasia Syndrome

Leukodystrophy, Hypomyelinating, Type 8, With/Without Oligodontia And/Or Hypogonadotropic Hypogonadism

Potocki-Shaffer Syndrome

Proximal 11p Deletion Syndrome

Chromosome 11p11.2 Deletion Syndrome

Pss

11p11.2 Deletion

P11pds

Defect11 Syndrome

Deletion Of Chromosome 11p11.2

POSHS

Aphthous Stomatitis

Oral Ulcer

Canker Sore

Aphtha

Aphthous Ulceration

Oral Aphthae

Oral Aphthous Ulcer

Canker Sores

Stomatitis, Aphthous

Minor Oral Aphthous Ulceration

Autoimmune Disease Of Exocrine System
Asthma

Chronic Obstructive Asthma

Asthma, Diminished Response To Antileukotriene Treatment In

Bronchial Hyperreactivity

Asthma, Susceptibility To

Asthma, Bronchial

Asthma, Protection Against

Asthma, Nocturnal, Susceptibility To

Nocturnal Asthma

Asthma-Related Traits

Asthma-Related Traits, Susceptibility To

Asthma, Nocturnal

Chronic Obstructive Asthma With Acute Exacerbation

Chronic Obstructive Asthma With Status Asthmaticus

Exercise Induced Asthma

Exercise-Induced Asthma

Bronchial Asthma

Asthma, Exercise-Induced

Idiosyncratic Asthma

Unspecified Asthma With Acute Exacerbation

Asthma, Unspecified, With Stated Status Asthmaticus

Status Asthmaticus Nos

Acute Severe Asthma

Acute Severe Bronchial Asthma

Status Asthma

Status Post Asthmaticus

Limited Scleroderma

Limited Cutaneous Systemic Sclerosis

Limited Systemic Sclerosis

Systemic Sclerosis Sine Scleroderma

Crest Syndrome

Limited Cutaneous Systemic Scleroderma

Scleroderma, Limited

Systemic Sclerosis, Limited

Progressive Systemic Sclerosis Sine Scleroderma

Scleroderma, Sine

Crest - [Calcinosis, Raynaud Phenomenon, Oesophageal Dysmotility, Sclerodactyly, And Telangiectasia] Syndrome

Crst - [Calcinosis, Raynaud Phenomenon, Sclerodactyly And Telangiectasia] Syndrome

Immune Deficiency Disease

Immunodeficiency

Primary Immunodeficiency

Primary Immunodeficiency Disease

Immunologic Deficiency Syndromes

Hypoimmunity

Immune Deficiency Disorder

Immunodeficiency Syndrome

Immune Disorder

Primary Immune Deficiency Disorder

Immune System Diseases

Human Immunodeficiency Virus Infection

Hiv - [Human Immunodeficiency Virus Infection]

Hiv Positive Nos

Hiv Disease

Acquired Immune Deficiency Syndrome-Related Complex

Aids-Like Syndrome

Aids-Related Complex Nos

Arc - [Aids-Related Complex]

Immunodeficiency Due To Human Immunodeficiency Virus Infection

Unspecified Human Immunodeficiency Virus Disease

Hiv Disease Nos

Human Immunodeficiency Virus Positive Nos

Hiv Nos

Deficiency Of Complement Initial Pathway

Deficiency Of Complement Terminal Pathway

Cfdd - [Complement Factor D Deficiency]

Immunodeficiency With Nk-Cell - [Natural-Killer Cell] Deficiency

Nonfamilial Hypogammaglobulinaemia

Common Variable Immune Deficiency

Nonfamilial Agammaglobulinaemia

Common Variable Agammaglobulinaemia

Agammaglobulinaemia Nos

Agammaglobulinaemia Antibody Deficiency Syndrome

Hypogammaglobulinaemia Antibody Deficiency Syndrome

Acquired Agammaglobulinaemia Nos

Hypogammaglobulinaemia Nos

Hyper Igm

Primary Biliary Cholangitis

Primary Biliary Cirrhosis

Biliary Liver Cirrhosis

Chronic Nonsuppurative Destructive Cholangitis

Familial Primary Biliary Cirrhosis

Pbc

Hanot Syndrome

Cholestatic Cirrhosis

Biliary Cirrhosis Primary

Liver Cirrhosis, Biliary

Hanot'S Cirrhosis

Biliary Cirrhosis

Pericholangiolic Biliary Cirrhosis

Tannhauser-Magendantz Syndrome

Hanot-Rossle Syndrome

Hypertrophic Cirrhosis

Todd Cirrhosis

Hanot Cirrhosis

Charcot Cirrhosis

Mahon-Tannhauser Syndrome

Toxic Cirrhosis

Hypertrophic Biliary Cirrhosis

Monolobular Cirrhosis

Unilobar Cirrhosis

Xanthomatous Biliary Cirrhosis

Celiac Disease 1

Celiac Disease

Coeliac Disease

Celiac Sprue

Celiac Disease, Susceptibility To

Gluten-Sensitive Enteropathy

Nontropical Sprue

Sprue

CELIAC1

Celiac Disease, Susceptibility To, 1

Celiac Sprue 1

Celiac Sprue, Susceptibility To, 1

Gluten-Sensitive Enteropathy 1

Gluten-Sensitive Enteropathy, Susceptibility To, 1

Idiopathic Steatorrhea

Cœliac Disease

Gluten Intolerance

Gluten-Induced Enteropathy

Gluten Enteropathy

Celiac Disease, Susceptibility To, Type 1

Childhood Celiac Disease

Coeliac Rickets

Gee Disease

Gee-Herter Disease

Heubner-Herter Disease

Idiopathic Steatorrhoea

Thaysen'S Disease

Herter Gee Syndrome

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Mus musculus STAT4 MGD MGI:103062
Bos taurus STAT4 VGNC VGNC:106954
Rattus norvegicus STAT4 RGD RGD:1305747
Macaca mulatta STAT4 VGNC VGNC:77907
Canis familiaris STAT4 VGNC VGNC:103708
Felis catus STAT4 VGNC VGNC:80367
Others STAT4 NCBI