SULT1A2 蛋白, Human (His)

Sulfotransferase 1A2 (SULT1A2) is a phenol sulfotransferase with thermostable enzyme activity. SULT1A2 utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of catecholamines, phenolic drugs and neurotransmitters. SULT1A2 is also responsible for the sulfonation and activation of minoxidil. SULT1A2 induces the mutagenicity and carcinogenicity of certain substrates by influencing DNA adduct formation. SULT1A2 Protein, Human (His) is the recombinant human-derived SULT1A2 protein, expressed by E. coli , with N-6*His labeled tag. The total length of SULT1A2 Protein, Human (His) is 295 a.a., with molecular weight of ~33.0 kDa.

磺基转移酶 1A2 (SULT1A2) 是一种具有热稳定酶活性的苯酚磺基转移酶。SULT1A2 利用 3'-磷酸-5'-腺苷酸硫酸盐 (PAPS) 作为磺酸盐供体，催化儿茶酚胺、酚类药物和神经递质的磺酸盐偶联。SULT1A2 还负责米诺地尔的磺化和活化。SULT1A2 通过影响 DNA 加合物的形成来诱导底物（包括硝基甲苯、3-硝基苯并酮、马兜铃酸、芳香羟胺和多环芳烃）的致突变性和致癌性，如果 SULT1A2 被表达为功能性蛋白，就会在这些底物的化学致癌作用中发挥作用^[1][2][3]。

Human

E. coli

N-6*His

AAI13728.1 (M1-L295)

6799  [NCBI]

MELIQDISRPPLEYVKGVPLIKYFAEALGPLQSFQARPDDLLISTYPKSGTTWVSQILDMIYQGGDLEKCHRAPIFMRVPFLEFKVPGIPSGMETLKNTPAPRLLKTHLPLALLPQTLLDQKVKVVYVARNAKDVAVSYYHFYHMAKVYPHPGTWESFLEKFMAGEVSYGSWYQHVQEWWELSRTHPVLYLFYEDMKENPKREIQKILEFVGRSLPEETVDLMVEHTSFKEMKKNPMTNYTTVRREFMDHSISPFMRKGMAGDWKTTFTVAQNERFDADYAEKMAGCSLSFRSEL

Approximately 33.0 kDa

Greater than 95% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.