1. Gene
  2. SULT1A2 - sulfotransferase family 1A member 2 Gene

SULT1A2 - sulfotransferase family 1A member 2 Gene

中文名称:磺基转移酶家族 1A 成员 2

种属: Homo sapiens

同用名: STP2; HAST4; P-PST; ST1A2; TSPST2; P-PST 2

基因 ID: 6799 | 基因类型: protein coding

关于 SULT1A2

Cytogenetic location: 16p11.2 Genomic coordinates (GRCh38): 16:28,591,943-28,597,050 (from NCBI)

This gene has 5 transcripts (splice variants), 762 orthologues and 12 paralogues. Biased expression in duodenum (RPKM 25.0), small intestine (RPKM 22.6) and 13 other tissues.

功能概要

磺基转移酶催化许多激素、神经递质、药物和异生化合物的硫酸盐结合。这些胞质酶的组织分布和底物特异性不同。家族成员之间的基因结构 (外显子的数量和长度) 相似。该基因编码具有热稳定性酶活性的两种苯酚磺基转移酶之一。已经描述了编码相同蛋白质的两种可变剪接变体。[RefSeq 提供,2008 年 7 月]

Sulfotransferase Enzymes catalyze the sulfate conjugation of many Hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic Enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene encodes one of two phenol sulfotransferases with thermostable Enzyme activity. Two alternatively spliced variants that encode the same protein have been described. [provided by RefSeq, Jul 2008]

SULT1A2 基因产物(10)

mRNA Protein Name
NM_001054.4 NP_001045.2 sulfotransferase 1A2 isoform 1
NM_001363863.2 NP_001350792.1 sulfotransferase 1A2 isoform 2
NM_001400258.1 NP_001387187.1 sulfotransferase 1A2 isoform 1
NM_001400259.1 NP_001387188.1 sulfotransferase 1A2 isoform 1
NM_001400260.1 NP_001387189.1 sulfotransferase 1A2 isoform 3
NM_001400261.1 NP_001387190.1 sulfotransferase 1A2 isoform 4
NM_001400262.1 NP_001387191.1 sulfotransferase 1A2 isoform 4
NM_001400263.1 NP_001387192.1 sulfotransferase 1A2 isoform 4
NM_001400264.1 NP_001387193.1 sulfotransferase 1A2 isoform 1
NM_177528.4 NP_803564.2 sulfotransferase 1A2 isoform 1
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables aryl sulfotransferase activity IDA
IDA: 通过直接分析推断
20417180 GOA
enables flavonol 3-sulfotransferase activity IDA
IDA: 通过直接分析推断
20056724 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
25416956 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in 3'-phosphoadenosine 5'-phosphosulfate metabolic process IDA
IDA: 通过直接分析推断
23207770 GOA
involved in ethanol catabolic process IDA
IDA: 通过直接分析推断
23207770 GOA
involved in phenol-containing compound metabolic process IDA
IDA: 通过直接分析推断
20417180 GOA
involved in sulfation IDA
IDA: 通过直接分析推断
20056724 GOA
involved in xenobiotic metabolic process IDA
IDA: 通过直接分析推断
20417180 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

SULT1A2 蛋白结构

Sulfotransfer_1

Sulfotransfer_1: Sulfotransferase domain (38 - 287)

  • 0
  • 100
  • 200
  • 295 a.a.
蛋白主名 其他名称

sulfotransferase 1A2

aryl sulfotransferase 2

SULT1A2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
SULT1A2 P50226 NIF3L1 Homo sapiens Q9GZT8
Validated Y2H
25416956
种属内
SULT1A2 P50226 NIF3L1 Homo sapiens Q9GZT8
Y2H Array
25416956
种属内
SULT1A2 P50226 NIF3L1 Homo sapiens Q9GZT8
Y2H Prey Pooling
25416956
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 SULT1A2 蛋白

目录号 产品名 蛋白编号 纯度
HY-P71001 SULT1A2 Protein, Human (His) AAI13728.1 (M1-L295) ≥95%

关联疾病

疾病名称 别名
Mandibulofacial Dysostosis With Alopecia

MFDA

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Mus musculus SULT1A2 MGD MGI:102896
Others SULT1A2 NCBI