SULT2B1 蛋白, Human (311a.a, His)

The SULT2B1 protein uses PAPS to catalyze sulfate conjugation, mainly sulfating cholesterol, and shows significant activity on steroids such as pregnenolone and DHEA. It plays a crucial role in epidermal cholesterol metabolism, regulating epidermal proliferation and differentiation. SULT2B1 Protein, Human (311a.a, His) is the recombinant human-derived SULT2B1 protein, expressed by E. coli , with C-6*His labeled tag. The total length of SULT2B1 Protein, Human (311a.a, His) is 311 a.a., with molecular weight of ~35.0 kDa.

SULT2B1 蛋白是一种利用 3'-磷酸-5'-腺苷酸硫酸盐 (PAPS) 作为磺酸盐供体的磺基转移酶，在催化硫酸盐结合中发挥着关键作用，主要负责硫酸化胆固醇。此外，SULT2B1 在硫酸化类固醇方面表现出显着的活性，尤其是孕烯醇酮和脱氢表雄酮 (DHEA) 等分子的 3β-羟基。虽然它表现出胆固醇的优先磺化作用，但它还表现出与孕烯醇酮和 DHEA 的显着活性。除了其酶功能外，SULT2B1 在表皮胆固醇代谢中发挥着至关重要的作用，有助于调节表皮增殖和分化。值得注意的是，它磺化孕烯醇酮，但不磺化胆固醇，强调其底物选择性，并强调其多方面参与控制胆固醇稳态和类固醇代谢的复杂过程。

Human

E. coli

C-6*His

O00204-1 (M1-E311)

6820  [NCBI]

MDGPAEPQIPGLWDTYEDDISEISQKLPGEYFRYKGVPFPVGLYSLESISLAENTQDVRDDDIFIITYPKSGTTWMIEIICLILKEGDPSWIRSVPIWERAPWCETIVGAFSLPDQYSPRLMSSHLPIQIFTKAFFSSKAKVIYMGRNPRDVVVSLYHYSKIAGQLKDPGTPDQFLRDFLKGEVQFGSWFDHIKGWLRMKGKDNFLFITYEELQQDLQGSVERICGFLGRPLGKEALGSVVAHSTFSAMKANTMSNYTLLPPSLLDHRRGAFLRKGVCGDWKNHFTVAQSEAFDRAYRKQMRGMPTFPWDE

Approximately 35.0-38.0 kDa

Greater than 95% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.