SULT2B1 - sulfotransferase family 2B member 1 Gene

中文名称：磺基转移酶家族 2B 成员 1

种属: Homo sapiens

同用名: HSST2; ARCI14

基因 ID: 6820 | 基因类型: protein coding

关于 SULT2B1

Cytogenetic location: 19q13.33 Genomic coordinates (GRCh38): 19:48,552,172-48,599,427 (from NCBI)

This gene has 4 transcripts (splice variants), 170 orthologues, 12 paralogues and is associated with 2 phenotypes. Biased expression in esophagus (RPKM 55.8), skin (RPKM 46.5) and 4 other tissues.

功能概要

磺基转移酶催化许多激素、神经递质、药物和异生化合物的硫酸盐结合。这些胞质酶的组织分布和底物特异性不同。家族成员之间的基因结构 (外显子的数量和长度) 相似。该基因硫酸化脱氢表雄酮但不硫酸化 4-硝基苯酚，后者是苯酚和雌激素磺基转移酶亚家族的典型底物。已经描述了编码不同亚型的两种可变剪接变体。[RefSeq 提供，2008 年 7 月]

Sulfotransferase Enzymes catalyze the sulfate conjugation of many Hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic Enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene sulfates dehydroepiandrosterone but not 4-nitrophenol, a typical substrate for the phenol and estrogen sulfotransferase subfamilies. Two alternatively spliced variants that encode different isoforms have been described. [provided by RefSeq, Jul 2008]

SULT2B1 基因产物(2)

mRNA	Protein	Name
NM_004605.2	NP_004596.2	sulfotransferase 2B1 isoform a
NM_177973.2	NP_814444.1	sulfotransferase 2B1 isoform b

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables cholesterol binding	IDA IDA: 通过直接分析推断	12923182	GOA
enables nucleic acid binding	IMP IMP: 通过突变表型推断	12923182	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	16189514	GOA
enables small molecule binding	EXP EXP: 通过实验结果推断	12923182	GOA
enables steroid hormone binding	IMP IMP: 通过突变表型推断	12923182	GOA
enables steroid sulfotransferase activity	IDA IDA: 通过直接分析推断	9799594	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in 3'-phosphoadenosine 5'-phosphosulfate metabolic process	IDA IDA: 通过直接分析推断	12923182	GOA
involved in cholesterol metabolic process	IMP IMP: 通过突变表型推断	28575648	GOA
involved in negative regulation of cell population proliferation	IMP IMP: 通过突变表型推断	28575648	GOA
involved in positive regulation of epidermal cell differentiation	IMP IMP: 通过突变表型推断	28575648	GOA
involved in steroid metabolic process	IDA IDA: 通过直接分析推断	9799594	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in cytosol	IDA IDA: 通过直接分析推断	28575648	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SULT2B1 蛋白结构

Sulfotransfer_1

0
100
200
300
365 a.a.

蛋白主名

其他名称

sulfotransferase 2B1

ST2B1

SULT2B1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	SULT2B1	O00204	SULT1B1	Homo sapiens	O43704	Y2H Bait-Prey Pool	25910212
种属内	SULT2B1	O00204	SULT1B1	Homo sapiens	O43704	Y2H Array	32296183
种属内	SULT2B1	O00204	SULT1B1	Homo sapiens	O43704	Validated Y2H	25910212
种属内	SULT2B1	O00204	SULT1B1	Homo sapiens	O43704	Y2H Prey Pooling	25416956
种属内	SULT2B1	O00204	SULT1B1	Homo sapiens	O43704	Y2H Array	25910212
种属内	SULT2B1	O00204	SULT1B1	Homo sapiens	O43704	Validated Y2H	25416956
种属内	SULT2B1	O00204	SULT1B1	Homo sapiens	O43704	Y2H Prey Pooling	32296183
种属内	SULT2B1	O00204	SULT1B1	Homo sapiens	O43704	Validated Y2H	32296183
种属内	SULT2B1	O00204	ACYP2	Homo sapiens	P14621	Y2H Array	25416956
种属内	SULT2B1	O00204	ZNF497	Homo sapiens	Q6ZNH5	Y2H Prey Pooling	32296183
种属内	SULT2B1	O00204	ZNF497	Homo sapiens	Q6ZNH5	Y2H Array	32296183
种属内	SULT2B1	O00204	ZNF497	Homo sapiens	Q6ZNH5	Validated Y2H	32296183
种属内	SULT2B1	O00204	SRP72	Homo sapiens	O76094	Validated Y2H	32296183
种属内	SULT2B1	O00204	SRP72	Homo sapiens	O76094	Y2H Array	32296183
种属内	SULT2B1	O00204	SRP72	Homo sapiens	O76094	Y2H Prey Pooling	32296183
种属内	SULT2B1	O00204	REL	Homo sapiens	Q04864-2	Validated Y2H	32296183
种属内	SULT2B1	O00204	REL	Homo sapiens	Q04864-2	Y2H Array	32296183
种属内	SULT2B1	O00204	REL	Homo sapiens	Q04864-2	Y2H Prey Pooling	32296183
种属内	SULT2B1	O00204	FLACC1	Homo sapiens	Q96Q35-2	Y2H Bait-Prey Pool	25910212
种属内	SULT2B1	O00204	FLACC1	Homo sapiens	Q96Q35-2	Validated Y2H	25910212
种属内	SULT2B1	O00204	FLACC1	Homo sapiens	Q96Q35-2	Y2H Array	25910212
种属内	SULT2B1	O00204	FLACC1	Homo sapiens	Q96Q35-2	Y2H Prey Pooling	32296183
种属内	SULT2B1	O00204	FLACC1	Homo sapiens	Q96Q35-2	Validated Y2H	32296183
种属内	SULT2B1	O00204	FLACC1	Homo sapiens	Q96Q35-2	Y2H Array	32296183
种属内	SULT2B1	O00204	KLHL8	Homo sapiens	Q9P2G9-2	Validated Y2H	32296183
种属内	SULT2B1	O00204	KLHL8	Homo sapiens	Q9P2G9-2	Y2H Prey Pooling	32296183
种属内	SULT2B1	O00204	KLHL8	Homo sapiens	Q9P2G9-2	Y2H Array	32296183
种属内	SULT2B1	O00204	SULT1C3	Homo sapiens	Q6IMI6	Y2H Prey Pooling	32296183
种属内	SULT2B1	O00204	SULT1C3	Homo sapiens	Q6IMI6	Validated Y2H	32296183
种属内	SULT2B1	O00204	SULT1C3	Homo sapiens	Q6IMI6	Y2H Array	32296183
种属内	SULT2B1	O00204	PRICKLE3	Homo sapiens	O43900	Y2H Prey Pooling	25416956
种属内	SULT2B1	O00204	PRICKLE3	Homo sapiens	O43900	Y2H Array	25416956
种属内	SULT2B1	O00204	SULT1A1	Homo sapiens	P50225	Validated Y2H	25910212
种属内	SULT2B1	O00204	SULT1A1	Homo sapiens	P50225	Y2H Array	31515488
种属内	SULT2B1	O00204	SULT1A1	Homo sapiens	P50225	Y2H Bait-Prey Pool	25910212
种属内	SULT2B1	O00204	SULT1A1	Homo sapiens	P50225	Y2H Array	25910212
种属内	SULT2B1	O00204	SULT1A1	Homo sapiens	P50225	Validated Y2H	25416956
种属内	SULT2B1	O00204	DDIT4L	Homo sapiens	Q96D03	Y2H Prey Pooling	32296183
种属内	SULT2B1	O00204	DDIT4L	Homo sapiens	Q96D03	Validated Y2H	32296183
种属内	SULT2B1	O00204	DDIT4L	Homo sapiens	Q96D03	Y2H Array	32296183
种属内	SULT2B1	O00204	FLACC1	Homo sapiens	Q96Q35	Y2H Pooling	16189514
种属内	SULT2B1	O00204	FLACC1	Homo sapiens	Q96Q35	Y2H Array	25416956
种属内	SULT2B1	O00204	FLACC1	Homo sapiens	Q96Q35	Y2H Prey Pooling	25416956
种属内	SULT2B1	O00204	FLACC1	Homo sapiens	Q96Q35	Y2H Pooling	19060904
种属内	SULT2B1	O00204	FLACC1	Homo sapiens	Q96Q35	Y2H Array	19060904

种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 SULT2B1 蛋白

目录号	产品名	蛋白编号	纯度
HY-P71011	SULT2B1 Protein, Human (311a.a, His)	O00204-1 (M1-E311)	≥95%
HY-P76666	SULT2B1 Protein, Human (364a.a, His)	O00204-1 (D2-S365)	≥95%

关联疾病

疾病名称

别名

Ichthyosis, Congenital, Autosomal Recessive 14

ARCI14

Autosomal Recessive Congenital Ichthyosis 14

Ichthyosis, Congenital, Autosomal Recessive 1

Collodion Fetus	Autosomal Recessive Congenital Ichthyosis 1
ARCI1	Ichthyosis Congenita
Lamellar Exfoliation Of Newborn	Desquamation Of Newborn
Ichthyosis Congenita Ii	Shcb
Icr2	Bathing Suit Ichthyosis
Li1	Self-Healing Collodion Baby
Ichthyosis, Congenital, Autosomal Recessive 1, With Bathing Suit Distribution	Collodion Baby, Self-Healing
Ichthyosis, Lamellar, 1, Formerly	Li1, Formerly
Ichthyosis Lamellar 1	Lamellar Ichthyosis, Type 1
Bsi	Autosomal Recessive Congenital Ichthyosis 1 With Bathing Suit Distribution
Autosomal Recessive Congenital Ichthyosis Tgm1-Related	Lamellar Ichthyosis 1
Non-Erythrodermic Ichthyosis	Ichthyosis, Congenital, Autosomal Recessive, Type 1
Congenital Ichthyosis

Ichthyosis, Congenital, Autosomal Recessive 2

Autosomal Recessive Congenital Ichthyosis 2	ARCI2
Ncie1	Ichthyosiform Erythroderma, Congenital
Collodion Baby, Self-Healing	Ichthyosiform Erythroderma, Nonbullous Congenital, 1, Formerly
Ncie1, Formerly	Ichthyosiform Erythroderma, Brocq Congenital, Nonbullous Form, Formerly
Brocq Congenital Ichthyosiform Erythroderma Nonbullous Form	Nonbullous Congenital Ichthyosiform Erythroderma 1
Cie	Ichthyosiform Erythroderma Brocq Congenital Non-Bullous Form
Iecn1	Non-Bullous Congenital Ichthyosiform Erythroderma Type 1
Self-Healing Collodion Baby	Ichthyosis, Congenital, Autosomal Recessive, Type 2
Ichthyosiform Erythroderma, Congenital, Nonbullous, 1

Autosomal Recessive Congenital Ichthyosis

Lamellar Ichthyosis	Congenital Ichthyosiform Erythroderma
Li	Congenital Nonbullous Ichthyosiform Erythroderma
Arci	Congenital Lamellar Ichthyosis
Nonbullous Congenital Ichthyosiform Erythroderma	Cie
Congenital Non-Bullous Ichthyosiform Erythroderma	Erythrodermic Ichthyosis
Nbcie	Ncie
Non-Bullous Congenital Ichthyosiform Erythroderma	Collodion Baby
Ichthyosis, Lamellar	Non Bullous Congenital Ichthyosiform Erythroderma
Ichthyosiform Erythroderma, Brocq Congenital, Nonbullous Form	Ichthyosiform Erythroderma, Congenital, Nonbullous, 1
Collodion Baby Syndrome	Ichthyoses, Lamellar
Nbie	Nonbullous Ichthyosiform Erythroderma
Classic Lamellar Ichthyosis	Ichthyosiform Erythroderma Nonbullous Congenital
Ichthyosiform Erythroderma Congenital	Ichthyosis, Congenital, Autosomal Recessive
Ichthyosiform Erythroderma, Congenital	Collodion Fetus
Non-Bullous Ichthyosiform Erythroderma

Ichthyosis

Ichthyoses	Non-Syndromic Ichthyosis
Congenital Ichthyosis

Ichthyosis, Congenital, Autosomal Recessive 4b

Harlequin Ichthyosis	Autosomal Recessive Congenital Ichthyosis 4b
Hi	Harlequin Fetus
ARCI4B	Ichthyosis Congenita, Harlequin Fetus Type
Harlequin Type Ichthyosis	'Harlequin Fetus'
Harlequin Type Ichthyosis Congenita	Harlequin Type Ichthyosis Fetalis
Harlequin Baby Syndrome	Ichthyosis Congenita, Harlequin Type
Ichthyosis Fetalis, Harlequin Type	Ichthyosis Congenita Harlequin Fetus Type
Ichthyosis, Harlequin	Ichthyosis, Congenital, Autosomal Recessive, Type 4b

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS14021	SULT2B1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Felis catus	SULT2B1	VGNC	VGNC:65837
Rattus norvegicus	SULT2B1	RGD	RGD:1308882
Mus musculus	SULT2B1	MGD	MGI:1926342
Canis familiaris	SULT2B1	VGNC	VGNC:46979
Bos taurus	SULT2B1	VGNC	VGNC:35468
Others	SULT2B1	NCBI

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