2. 重组蛋白
  3. CD Antigens
  4. Dendritic Cell CD Proteins
  5. 8D6A/CD320
  6. TCblR/CD320 蛋白, Mouse (HEK293, Fc)

TCblR/CD320 蛋白, Mouse (HEK293, Fc)

目录号: HY-P76797
产品使用指南

TCblR/CD320 蛋白是钴胺素饱和转钴胺素 (TCbl) 的受体，在钴胺素摄取中发挥着关键作用，在质膜上表达，尤其是在滤泡树突细胞 (FDC) 上。作为共刺激剂，TCblR 促进 B 细胞反应，促进分化和增殖。它对于分化生发中心 B 细胞、参与与 T 细胞和 FDC 的协作相互作用特别有影响力。CD320 增强 IL-10 诱导的前体增殖，强调其通过与 TCN2 相互作用在钴胺素稳态和细胞过程中的重要性。TCblR/CD320 蛋白, Mouse (HEK293, Fc) 是重组的 TCblR/CD320 蛋白，由 HEK293 表达，带有 C-hFc 标签。TCblR/CD320 蛋白, Mouse (HEK293, Fc) 全长 208 个氨基酸，分子量约为 ~72.5 kDa。

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描述

TCblR/CD320 Protein, the receptor for cobalamin-saturated transcobalamin (TCbl), plays a pivotal role in cobalamin uptake, expressed on the plasma membrane and notably on follicular dendritic cells (FDC). As a costimulator, TCblR promotes B cell responses, fostering differentiation and proliferation. It's particularly influential in differentiating germinal center-B cells, engaging in collaborative interactions with T-cells and FDC. CD320 enhances IL-10-induced precursor proliferation, underscoring its significance in cobalamin homeostasis and cellular processes through interactions with TCN2. TCblR/CD320 Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived TCblR/CD320 protein, expressed by HEK293, with C-hFc labeled tag. The total length of TCblR/CD320 Protein, Mouse (HEK293, Fc) is 208 a.a., with molecular weight of ~72.5 kDa.
研究背景

TCblR/CD320 蛋白作为钴胺素饱和转钴胺素 (TCbl) 的受体，在钴胺素摄取中发挥着关键作用。它位于质膜上，主要在滤泡树突细胞 (FDC) 上表达，促进与生发中心 B 细胞的相互作用。TCblR 作为共刺激剂，促进 B 细胞对抗原刺激的反应，从而促进 B 细胞分化和增殖。TCblR 对生发中心 B (GC-B) 细胞向记忆 B 细胞和浆细胞 (PC) 的分化特别有影响，它与 T 细胞和滤泡树突细胞 (FDC) 协同相互作用。它的作用延伸到增强 IL-10 产生的 PC 前体的增殖。CD320 与 TCN2 的相互作用通过其 LDL 受体 A 类结构域介导，强调了其在钴胺素稳态和细胞过程中的重要性。
种属

Mouse
表达系统

HEK293
标签

C-hFc
蛋白编号

Q9Z1P5 (M1-G208)
基因 ID
蛋白结构
N-term
CD320 (M1-G208)
Accession # Q9Z1P5
hFc
C-term
同用名
CD320 antigen; 8D6 antigen; FDC-signaling molecule 8D6; FDC-SM-8D6; Transcobalamin receptor; TCblR; CD320
分子量

Approximately 72.5 kDa
纯度

Greater than 95% as determined by reducing SDS-PAGE
内毒素含量

<1 EU/μg, determined by LAL method.
文件资料
产品使用指南 (1213 KB)

TCblR/CD320 Protein, Mouse (HEK293, Fc) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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