TIM-4/TIMD-4 蛋白, Human (Biotinylated, HEK293, His)

TIM-4/TIMD-4 protein is a multifunctional phosphatidylserine receptor involved in multiple immune response functions. It participates in phagocytosis of apoptotic cells and exerts a bimodal regulatory effect on T cell activation—inhibiting initial T cell activation while promoting the proliferation of activated T cells through AKT1 and ERK1/2 phosphorylation. TIM-4/TIMD-4 Protein, Human (Biotinylated, HEK293, His) is the recombinant human-derived TIM-4/TIMD-4 protein, expressed by HEK293 , with C-His labeled tag.

TIM-4/TIMD-4 蛋白是一种多功能磷脂酰丝氨酸受体，在免疫反应中发挥多种作用。它参与凋亡细胞的吞噬作用，并以双模式方式调节 T 细胞活化，抑制初始 T 细胞活化，同时通过 AKT1 和 ERK1/2 磷酸化及后续信号通路促进活化 T 细胞增殖。TIM-4/TIMD-4 还通过直接与凋亡细胞上的磷脂酰丝氨酸结合，参与胞吞作用，即吞噬细胞清除凋亡细胞的过程。它还通过在磷脂酰丝氨酸依赖性机制中激活 LKB1/PRKAA1 途径来抑制 NLRP3 炎性体活性，从而促进自噬。在微生物感染的情况下，TIM-4/TIMD-4 在外泌体介导的 HIV-1 病毒运输及其进入免疫细胞中发挥积极作用。

Human

HEK293

C-His

AAH08988.1 (E25-L315)

91937  [NCBI]

MSKEPLILWLMIEFWWLYLTPVTSETVVTEVLGHRVTLPCLYSSWSHNSNSMCWGKDQCPYSGCKEALIRTDGMRVTSRKSAKYRLQGTIPRGDVSLTILNPSESDSGVYCCRIEVPGWFNDVKINVRLNLQRASTTTHRTATTTTRRTTTTSPTTTRQMTTTPAALPTTVVTTPDLTTGTPLQMTTIAVFTTANTCLSLTPSTLPEEATGLLTPEPSKEGPILTAESETVLPSDSWSSVESTSADTVLLTSKESKVWDLPSTSHVSMWKTSDSVSSPQPGASDTAVPEQNKTTKTGQMDGIPMSMKNEMPISQL

Approximately 32.7 kDa

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.