TMSB4X 蛋白, Human (His)

TMSB4X proteins play a critical role in cytoskeletal organization, influencing actin dynamics by binding and sequestering actin monomers. As a potent inhibitor of actin polymerization, it affects the cytoskeleton. TMSB4X Protein, Human (His) is the recombinant human-derived TMSB4X protein, expressed by E. coli , with N-6*His labeled tag. The total length of TMSB4X Protein, Human (His) is 43 a.a., with molecular weight of ~13 kDa.

TMSB4X 蛋白在细胞骨架组织中发挥着至关重要的作用，其对肌动蛋白动力学的影响已被证实。它通过结合和隔离肌动蛋白单体（G 肌动蛋白）发挥作用，从而充当肌动蛋白聚合的有效抑制剂。除了对细胞骨架的影响之外，TMSB4X 还作为骨髓源性干细胞分化的强力抑制剂，通过阻止造血多能干细胞进入 S 期来发挥其作用。这些多方面的功能强调了 TMSB4X 在协调基本细胞过程（包括细胞骨架完整性和干细胞分化）中的重要性，强调了其在维持细胞稳态和协调动态细胞反应中的调节作用。

Human

E. coli

N-6*His

P62328 (S2-S44)

7114  [NCBI]

SDKPDMAEIEKFDKSKLKKTETQEKNPLPSKETIEQEKQAGES

Approximately 13 kDa

• 
  Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized from a 0.2 μm filtered solution of 50 mM Tris-HCL, 300 mM NaCl, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US;may vary elsewhere.