TMSB4X - thymosin beta 4 X-linked Gene

中文名称：胸腺素 beta 4 X 连锁

种属: Homo sapiens

同用名: FX; TB4X; PTMB4; TMSB4

基因 ID: 7114 | 基因类型: protein coding

关于 TMSB4X

Cytogenetic location: Xp22.2 Genomic coordinates (GRCh38): X:12,975,110-12,977,223 (from NCBI)

This gene has 4 transcripts (splice variants), 34 orthologues, 1 paralogue and is associated with 32 phenotypes. Broad expression in spleen (RPKM 3301.5), lymph node (RPKM 3201.4) and 24 other tissues.

功能概要

该基因编码一种肌动蛋白螯合蛋白，该蛋白在调节肌动蛋白聚合中发挥作用。该蛋白质还参与细胞增殖、迁移和分化。该基因逃脱了 X 失活并在 Y 染色体上具有同源物。[RefSeq 提供，2008 年 7 月]

This gene encodes an actin sequestering protein which plays a role in regulation of actin polymerization. The protein is also involved in cell proliferation, migration, and differentiation. This gene escapes X inactivation and has a homolog on chromosome Y. [provided by RefSeq, Jul 2008]

TMSB4X 基因产物(1)

mRNA	Protein	Name
NM_021109.4	NP_066932.1	thymosin beta-4

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables actin monomer binding	IDA IDA: 通过直接分析推断	1447300	GOA
enables enzyme binding	IPI IPI: 通过物理相互作用推断	21106936	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	17967441	GOA
enables protein sequestering activity	IMP IMP: 通过突变表型推断	21343177	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
acts upstream of or within positive effect negative regulation of canonical NF-kappaB signal transduction	IMP IMP: 通过突变表型推断	21343177	GOA
involved in negative regulation of hematopoietic stem cell differentiation	IDA IDA: 通过直接分析推断	7694679	GOA
involved in negative regulation of inflammatory response	IMP IMP: 通过突变表型推断	21343177	GOA
involved in positive regulation of ATP biosynthetic process	IDA IDA: 通过直接分析推断	21106936	GOA
involved in positive regulation of blood vessel endothelial cell migration	IDA IDA: 通过直接分析推断	21106936	GOA
involved in positive regulation of blood vessel endothelial cell migration	IGI IGI: 通过遗传相互作用推断	21106936	GOA
involved in positive regulation of endothelial cell chemotaxis	IDA IDA: 通过直接分析推断	21106936	GOA
involved in positive regulation of proton-transporting ATP synthase activity, rotational mechanism	IDA IDA: 通过直接分析推断	21106936	GOA
involved in sequestering of actin monomers	IDA IDA: 通过直接分析推断	1447300	GOA
acts upstream of or within positive effect tumor necrosis factor-mediated signaling pathway	IMP IMP: 通过突变表型推断	21343177	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in cytoplasm	IDA IDA: 通过直接分析推断	21343177	GOA
located in cytosol	IDA IDA: 通过直接分析推断	1447300	GOA
located in nucleus	IDA IDA: 通过直接分析推断	21343177	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

TMSB4X 蛋白结构

Thymosin

0
44 a.a.

蛋白主名

其他名称

thymosin beta-4

prothymosin beta-4

TMSB4X 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	TMSB4X	P62328	KRTAP8-1	Homo sapiens	Q8IUC2	Validated Y2H	32296183
种属内	TMSB4X	P62328	KRTAP8-1	Homo sapiens	Q8IUC2	Y2H Array	32296183
种属内	TMSB4X	P62328	KRTAP8-1	Homo sapiens	Q8IUC2	Y2H Prey Pooling	32296183
种属内	TMSB4X	P62328	KRT34	Homo sapiens	O76011	Y2H Prey Pooling	32296183
种属内	TMSB4X	P62328	KRT34	Homo sapiens	O76011	Y2H Array	32296183
种属内	TMSB4X	P62328	KRT36	Homo sapiens	O76013-2	Y2H Array	32296183
种属内	TMSB4X	P62328	KRT36	Homo sapiens	O76013-2	Y2H Prey Pooling	32296183
种属内	TMSB4X	P62328	UHMK1	Homo sapiens	Q8TAS1-2	Validated Y2H	32296183
种属内	TMSB4X	P62328	UHMK1	Homo sapiens	Q8TAS1-2	Y2H Prey Pooling	32296183
种属内	TMSB4X	P62328	UHMK1	Homo sapiens	Q8TAS1-2	Y2H Array	32296183
种属内	TMSB4X	P62328	AKAP8L	Homo sapiens	Q9ULX6	Y2H Array	32296183
种属内	TMSB4X	P62328	AKAP8L	Homo sapiens	Q9ULX6	Validated Y2H	32296183
种属内	TMSB4X	P62328	AKAP8L	Homo sapiens	Q9ULX6	Y2H Prey Pooling	32296183
种属内	TMSB4X	P62328	COG6	Homo sapiens	Q9Y2V7	Y2H Array	32296183
种属内	TMSB4X	P62328	COG6	Homo sapiens	Q9Y2V7	Y2H Prey Pooling	32296183
种属内	TMSB4X	P62328	COG6	Homo sapiens	Q9Y2V7	Validated Y2H	32296183
种属内	TMSB4X	P62328	GOLGA6L9	Homo sapiens	A6NEM1	Y2H Array	32296183
种属内	TMSB4X	P62328	GOLGA6L9	Homo sapiens	A6NEM1	Y2H Prey Pooling	32296183
种属内	TMSB4X	P62328	HSF2BP	Homo sapiens	O75031	Y2H Prey Pooling	32296183
种属内	TMSB4X	P62328	HSF2BP	Homo sapiens	O75031	Y2H Array	32296183
种属内	TMSB4X	P62328	FHL3	Homo sapiens	Q13643	Y2H Array	32296183
种属内	TMSB4X	P62328	FHL3	Homo sapiens	Q13643	Y2H Prey Pooling	32296183
种属内	TMSB4X	P62328	FHL3	Homo sapiens	Q13643	Validated Y2H	32296183
种属内	TMSB4X	P62328	MLH1	Homo sapiens	P40692	Anti Bait CoIP	17967441
种属内	TMSB4X	P62328	MLH1	Homo sapiens	P40692	Y2H	17967441
种属内	TMSB4X	P62328	MLH1	Homo sapiens	P40692	Anti Bait CoIP	20706999
种属内	TMSB4X	P62328	MLH1	Homo sapiens	P40692	Anti Tag CoIP	20706999
种属内	TMSB4X	P62328	MLH1	Homo sapiens	P40692	Confocal	17967441
种属内	TMSB4X	P62328	KRT31	Homo sapiens	Q15323	Y2H Array	32296183
种属内	TMSB4X	P62328	KRT31	Homo sapiens	Q15323	Y2H Prey Pooling	32296183
种属内	TMSB4X	P62328	KRT31	Homo sapiens	Q15323	Validated Y2H	32296183

种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 TMSB4X 蛋白

目录号	产品名	蛋白编号	纯度
HY-P72776	Thymosin beta 4 Protein, Human	P62328 (S2-S44)	≥95%
HY-P71930A	TMSB4X Protein, Human (His)	P62328 (S2-S44)	≥95%

关联疾病

疾病名称

别名

Osteoarthritis

Osteoarthrosis	Degenerative Joint Disease
Hypertrophic Arthritis	Arthropathy
Degenerative Polyarthritis	Degenerative Arthritis
Osteoarthrosis And Allied Disorder	Arthritis, Degenerative
Oa	Osteoarthritis Deformans
Osteoarthrosis Deformans	Kashin-Beck Disease

Pulmonary Systemic Sclerosis

Lung Disease With Systemic Sclerosis

Lung Involvement In Systemic Sclerosis

Invasive Malignant Thymoma

Infiltrating Thymoma	Thymoma Malignant Invasive
Invasive Thymoma And Thymic Carcinoma

Thymoma

Primary Thymic Epithelial Neoplasm	Primary Thymic Epithelial Tumor
Thymus Neoplasms

Lateral Myocardial Infarction

Fibrosarcoma

Neoplasms, Fibrous Tissue	Fibrocytic Tumor
Fibrosarcoma Of Soft Tissue	Fibrous Tissue Neoplasm

Keratopathy

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Malignant Iris Melanoma

Malignant Melanoma Of Iris

Melanoma Of The Iris

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS14775	TMSB4X Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Mus musculus	TMSB4X	MGD	MGI:99510
Rattus norvegicus	TMSB4X	RGD	RGD:621622

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

TMSB4X - thymosin beta 4 X-linked Gene

关于 TMSB4X

功能概要

TMSB4X 基因产物(1)

TMSB4X 蛋白结构

TMSB4X 蛋白互作信息

重组 TMSB4X 蛋白

关联疾病

直系同源

热门区域

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TMSB4X - thymosin beta 4 X-linked Gene

关于 TMSB4X

功能概要

TMSB4X 基因产物(1)

TMSB4X 蛋白结构

TMSB4X 蛋白互作信息

重组 TMSB4X 蛋白

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z