TSHR 蛋白, Human (sf9, His)

TSHR, a membrane protein, is a key regulator of thyroid cell metabolism. As a receptor for thyrothropin and thyrostimulin, its activity involves adenylate cyclase. Gene defects contribute to various hyperthyroidism types. The gene exhibits restricted expression in the thyroid (RPKM 104.1). TSHR Protein, Human (sf9, His) is the recombinant human-derived TSHR protein, expressed by Sf9 insect cells , with C-His labeled tag. The total length of TSHR Protein, Human (sf9, His) is 393 a.a., with molecular weight (affected by relative charge) of ~60 KDa.

该基因编码的 TSHR 蛋白是一种重要的膜蛋白，是甲状腺细胞代谢的主要调节因子。作为促甲状腺素和促甲状腺素的受体，其活性通过腺苷酸环化酶介导。该基因的遗传缺陷与各种形式的甲状腺功能亢进症有关，凸显了其在维持甲状腺功能中的关键作用。已鉴定出编码不同亚型的三种转录变体。此外，TSHR 的表达明显限于甲状腺，观察到的水平特别高 (RPKM 104.1)，强调了它在甲状腺组织中的专门性及其在控制甲状腺代谢的复杂调节机制中的中心地位。

Human

Sf9 insect cells

C-His

P16473-1/NP_000360.2 (G21-G413)

7253  [NCBI]

Approximately 56.6 KDa

Greater than 90% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized from a 0.2 μm filtered solution of 50mM Tris, 150mM NaCl, 10% Glycerol, 1mM TCEP, pH 7.5.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.