TYRO3/DTK 蛋白, Mouse (HEK293, hFc)

TYRO3/DTK protein is a receptor tyrosine kinase that transduces signals through ligands such as TULP1 or GAS6 to regulate cell survival, migration and differentiation.Ligand binding induces TYRO3 dimerization and autophosphorylation, creating docking sites for downstream molecules.TYRO3/DTK Protein, Mouse (HEK293, hFc) is the recombinant mouse-derived TYRO3/DTK protein, expressed by HEK293 , with C-hFc labeled tag.

TYRO3/DTK 蛋白是一种受体酪氨酸激酶，通过与各种配体（包括 TULP1 或 GAS6）结合来转导来自细胞外基质的信号。它在调节许多生理过程中发挥着至关重要的作用，包括细胞存活、迁移和分化。配体在细胞表面结合后，TYRO3 在其胞内结构域上发生二聚化和自磷酸化，为下游信号分子创建对接位点。激活后，TYRO3 与 PIK3R1 相互作用，增强 PI3 激酶活性并激活 AKT 生存途径，导致 NF-kappa-B 核转位和 NF-kappa-B 调节基因的转录上调。TYRO3 信号传导涉及神经元免受兴奋性毒性损伤、血小板聚集和细胞骨架重组等过程。此外，TYRO3 在通过激活 STAT1 抑制 Toll 样受体 (TLR) 介导的先天免疫反应中发挥着至关重要的作用，STAT1 选择性诱导细胞因子信号转导 SOCS1 和 SOCS3 抑制剂的产生。

Immobilized Mouse TYRO3 at 1 μg/mL (100 μL/well) can bind Biotinylated Mouse GAS6 protein. The ED₅₀ for this effect is 1.95 μg/mL.

Mouse

HEK293

C-hFc

P55144 (A31-S418)

22174  [NCBI]

AGLKLMGAPVKMTVSQGQPVKLNCSVEGMEDPDIHWMKDGTVVQNASQVSISISEHSWIGLLSLKSVERSDAGLYWCQVKDGEETKISQSVWLTVEGVPFFTVEPKDLAVPPNAPFQLSCEAVGPPEPVTIYWWRGLTKVGGPAPSPSVLNVTGVTQRTEFSCEARNIKGLATSRPAIVRLQAPPAAPFNTTVTTISSYNASVAWVPGADGLALLHSCTVQVAHAPGEWEALAVVVPVPPFTCLLRNLAPATNYSLRVRCANALGPSPYGDWVPFQTKGLAPARAPQNFHAIRTDSGLILEWEEVIPEDPGEGPLGPYKLSWVQENGTQDELMVEGTRANLTDWDPQKDLILRVCASNAIGDGPWSQPLVVSSHDHAGRQGPPHSRTS

90-120 kDa

Greater than 95% as determined by reducing SDS-PAGE

无菌粉末.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.