1. Gene
  2. Tyro3 - TYRO3 protein tyrosine kinase 3 Gene

Tyro3 - TYRO3 protein tyrosine kinase 3 Gene

种属: Mus musculus

同用名: Brt; Dtk; Rse; Sky; Tif; Etk-2; TK19-2; tk19-1; etk2/tyro3

基因 ID: 22174 | 基因类型: protein coding

关于 Tyro3

功能概要

Predicted to enable phosphatidylinositol 3-kinase binding activity; transmembrane receptor protein tyrosine kinase activity; and virus receptor activity. Involved in several processes, including negative regulation of defense response; platelet aggregation; and protein kinase B signaling. Acts upstream of or within several processes, including animal organ development; platelet activation; and substrate adhesion-dependent cell spreading. Predicted to be located in cell surface; endoplasmic reticulum membrane; and nuclear envelope. Predicted to be part of receptor complex. Predicted to be integral component of plasma membrane. Is expressed in several structures, including brain; genitourinary system; gut; limb; and sensory organ. Orthologous to human TYRO3 (TYRO3 protein tyrosine kinase). [provided by Alliance of Genome Resources, Apr 2022]

Tyro3 基因产物(2)

mRNA Protein Name
NM_001290800.1 NP_001277729.1 tyrosine-protein kinase receptor TYRO3 isoform B
NM_019392.2 NP_062265.2 tyrosine-protein kinase receptor TYRO3 isoform A precursor
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
18787040 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within apoptotic cell clearance IGI
IGI: 通过遗传相互作用推断
17442946 MGI
involved in apoptotic cell clearance IGI
IGI: 通过遗传相互作用推断
18159085 MGI
acts upstream of or within establishment of localization in cell IMP
IMP: 通过突变表型推断
15650770 MGI
acts upstream of or within forebrain cell migration IGI
IGI: 通过遗传相互作用推断
18787040 MGI
acts upstream of lymphocyte activation IGI
IGI: 通过遗传相互作用推断
11452127 MGI
acts upstream of or within natural killer cell differentiation IGI
IGI: 通过遗传相互作用推断
16751775 MGI
involved in negative regulation of inflammatory response IGI
IGI: 通过遗传相互作用推断
18083102 MGI
involved in negative regulation of innate immune response IGI
IGI: 通过遗传相互作用推断
18083102 MGI
acts upstream of or within negative regulation of lymphocyte activation IGI
IGI: 通过遗传相互作用推断
11452127 MGI
acts upstream of or within negative regulation of neuron apoptotic process IGI
IGI: 通过遗传相互作用推断
18787040 MGI
involved in negative regulation of toll-like receptor signaling pathway IGI
IGI: 通过遗传相互作用推断
18083102 MGI
acts upstream of neuron apoptotic process IGI
IGI: 通过遗传相互作用推断
18787040 MGI
involved in neuron cellular homeostasis IMP
IMP: 通过突变表型推断
21084607 MGI
acts upstream of or within neuron migration IGI
IGI: 通过遗传相互作用推断
18787040 MGI
acts upstream of or within neuropeptide signaling pathway IMP
IMP: 通过突变表型推断
9331176 MGI
acts upstream of or within ovulation cycle IGI
IGI: 通过遗传相互作用推断
18787040 MGI
acts upstream of or within platelet activation IMP
IMP: 通过突变表型推断
15650770 MGI
involved in platelet aggregation IMP
IMP: 通过突变表型推断
20546121 MGI
acts upstream of or within positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IGI
IGI: 通过遗传相互作用推断
15650770 MGI
involved in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
IMP: 通过突变表型推断
21084607 MGI
acts upstream of or within secretion by cell IMP
IMP: 通过突变表型推断
15650770 MGI
acts upstream of or within spermatogenesis IGI
IGI: 通过遗传相互作用推断
10227296 MGI
involved in spermatogenesis IGI
IGI: 通过遗传相互作用推断
10227296 MGI
acts upstream of or within substrate adhesion-dependent cell spreading IMP
IMP: 通过突变表型推断
15650770 MGI
acts upstream of or within vagina development IGI
IGI: 通过遗传相互作用推断
18393392 MGI
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断
蛋白主名 其他名称

tyrosine-protein kinase receptor TYRO3

receptor tyrosine kinase

tyrosine-protein kinase DTK

tyrosine-protein kinase RSE

tyrosine-protein kinase TIF

重组 Tyro3 蛋白

目录号 产品名 蛋白编号 纯度
HY-P70043 TYRO3/DTK Protein, Mouse (HEK293, hFc) P55144 (A31-S418) ≥95%
HY-P77863 TYRO3/DTK Protein, Mouse (HEK293, His) P55144-2 (R31-D419) ≥95%

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Tyro3 NCBI NCBI:7301
Macaca fascicularis Tyro3 NCBI NCBI:102135978