USP46 蛋白, Human/Mouse (sf9)

USP46 Protein, a ubiquitin-specific protease, is involved in the regulation of cellular processes and protein degradation. It has been found to play a critical role in synaptic plasticity and memory formation. USP46 Protein's potential as a therapeutic target in cognitive disorders and its impact on neurological function make it a subject of interest in neuroscience research. USP46 Protein, Human/Mouse (sf9) is the recombinant human, mouse-derived USP46 protein, expressed by Sf9 insect cells , with tag free. The total length of USP46 Protein, Human/Mouse (sf9) is 366 a.a., with molecular weight of ~43 kDa.

USP46 蛋白是一种去泛素化酶，可能通过调节 GABA 作用参与行为调节。研究表明，其作用可能涉及介导 GAD1/GAD67 的去泛素化。有趣的是，USP46 本身表现出最小的去泛素化活性，并依赖与 WDR48 的相互作用来实现高酶活性。与参与 GABA 相关过程相反，USP46 不参与单泛素化 FANCD2 的去泛素化，表明其底物相互作用具有特异性（通过相似性）。这种多方面的酶揭示了行为和神经递质动力学背后的复杂调节机制。

Human; Mouse

Sf9 insect cells

Tag Free

P62069 (M1-E366)

69727  [NCBI]

MTVRNIASICNMGTNASALEKDIGPEQFPINEHYFGLVNFGNTCYCNSVLQALYFCRPFRENVLAYKAQQKKKENLLTCLADLFHSIATQKKKVGVIPPKKFISRLRKENDLFDNYMQQDAHEFLNYLLNTIADILQEEKKQEKQNGKLKNGNMNEPAENNKPELTWVHEIFQGTLTNETRCLNCETVSSKDEDFLDLSVDVEQNTSITHCLRDFSNTETLCSEQKYYCETCCSKQEAQKRMRVKKLPMILALHLKRFKYMEQLHRYTKLSYRVVFPLELRLFNTSSDAVNLDRMYDLVAVVVHCGSGPNRGHYITIVKSHGFWLLFDDDIVEKIDAQAIEEFYGLTSDISKNSESGYILFYQSRE

Approximately 43 kDa

Greater than 95% as determined by reducing SDS-PAGE

无菌粉末.

Lyophilized from a 0.2 μm filtered solution of 20 mM Tris, 500 mM NaCl, pH 7.4, 10% Glycerol. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.