VEGFR-3/FLT4 蛋白, Human (HEK293, His)

VEGFR-2 protein is an important tyrosine protein kinase receptor that serves as a cell surface receptor for VEGFA, VEGFC and VEGFD to regulate angiogenesis, blood vessel development and embryonic hematopoiesis. It enhances endothelial cell proliferation, survival, migration and differentiation. VEGFR-3/FLT4 Protein, Human (HEK293, His) is the recombinant human-derived VEGFR-3/FLT4 protein, expressed by HEK293 , with C-His labeled tag.

VEGFR-2蛋白是一种酪氨酸蛋白激酶受体，在调节血管生成、血管发育、血管通透性和胚胎造血等多种过程中发挥着至关重要的作用。它作为 VEGFA、VEGFC 和 VEGFD 的细胞表面受体，促进内皮细胞的增殖、存活、迁移和分化。此外，缺乏跨膜结构域的异构体（例如异构体 2）充当 VEGFA、VEGFC 和/或 VEGFD 的诱饵受体，通过抑制这些生长因子与 FLT4 的结合，充当淋巴管生成的负调节因子。VEGFR-2 还与 FLT1 和 FLT4 形成异二聚体，调节它们的信号传导。血管生长因子激活异构体 1 会触发多个信号级联反应，包括激活 PLCG1，从而产生二酰基甘油和肌醇 1,4,5-三磷酸，以及激活蛋白激酶 C。它还会激活 MAPK1/ ERK2、MAPK3/ERK1 和 AKT1 信号通路，导致各种细胞反应。此外，VEGFR-2磷酸化PIK3R1，促进磷脂酰肌醇3-激酶的激活，并促进肌动蛋白细胞骨架重组和PTK2/FAK1的激活。它在 NOS2 和 NOS3 诱导中的作用导致内皮细胞产生一氧化氮 (NO)。此外，VEGFR-2 磷酸化 PLCG1 并促进 FYN、NCK1、NOS3、PIK3R1、PTK2/FAK1 和 SRC 磷酸化，进一步促进其多样化的细胞功能。

1.Measured by its binding ability in a functional ELISA.
2. Immobilized human VEGF-C at 10 μg/mL (100 μl/wel) can bind human VEGFR3-his The EC₅₀ of human VEGFR3-his is 0.011 μg/mL.

Human

HEK293

C-His

P35916-2/NP_002011.2 (Y25-I776)

2324  [NCBI]

Approximately 130 kDa

Greater than 95% as determined by reducing SDS-PAGE.

溶液

Supplied as sterile PBS. pH 7.4.

<1 EU/μg, determined by LAL method.

N/A.

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.