2. Metabolic Enzyme/Protease
  3. Renin
  4. Renin inhibitor-1

Renin inhibitor-1 (compound 26) 是一种有效且具有口服活性的肾素抑制剂，对 rh-renin 和 hPRA 的 IC50s 分别为 0.9, 1.8 nM。Renin inhibitor-1 显示出抗高血压功效。Renin inhibitor-1 具有研究高血压和心血管/肾脏疾病的潜力。

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Renin inhibitor-1 Chemical Structure

Renin inhibitor-1 Chemical Structure

CAS No. : 1093082-54-2

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Renin inhibitor-1 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Renin inhibitor-1 (compound 26) is a potent and orally active renin inhibitor with IC50s of 0.9, 1.8 nM for rh-renin and hPRA, respectively. Renin inhibitor-1 shows antihypertensive efficacy. Renin inhibitor-1 has the potential for the research of hypertension and cardiovascular/renal diseases[1].

IC50 & Target

IC50: 0.9 nM (rh-renin); 1.8 nM (hPRA)[1]
体内研究
(In Vivo)

Renin inhibitor-1 (compound 26) (10 mg/kg; p.o.) demonstrates a significantly potent hypotensive effect in tsukuba hypertensive mice[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

414.50

Formula

C22H30N4O4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Renin inhibitor-1 相关分类

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× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Renin inhibitor-11093082-54-2Renin inhibitor1Renin inhibitor 1Reninorally activeantihypertensivetsukuba hypertensive miceInhibitorinhibitorinhibit

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