2. Metabolic Enzyme/Protease
  3. Phosphodiesterase (PDE)
  4. Reticulol

Reticulol (K 251-1) 是环腺苷 3', 5'-单磷酸磷酸二酯酶的抑制剂。Reticulol 显示出与细胞周期停滞或细胞凋亡无关的抗肿瘤活性。Reticulol 抑制小鼠黑色素瘤细胞和人肺肿瘤细胞的细胞生长。 Reticulol 通过抑制 B16F10 黑色素瘤的生长通过血流保护其肺转移。

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Reticulol Chemical Structure

Reticulol Chemical Structure

CAS No. : 26246-41-3

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Reticulol 相关抗体

Top Publications Citing Use of Products

查看 Phosphodiesterase (PDE) 亚型特异性产品:

查看所有亚型
PDE1 PDE2 PDE3 PDE4 PDE5 PDE6 PDE7 PDE9 PDE10 PDE11 PDE12 PDE8 Autotaxin

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Reticulol (K 251-1) is an inhibitor of cyclic adenosine 3', 5'-monophosphate phosphodiesterase. Reticulol shows antitumor activity independent with cell cycle arrest or apoptosis. Reticulol inhibits cell growth of murine melanoma cells and human lung tumor cells. Reticulol protects its lung metastasis via the bloodstream by inhibiting the growth of B16F10 melanoma[1][2].

体外研究
(In Vitro)

Reticulol (25-200 μM) 对人肺肿瘤细胞系 A427 和小鼠黑色素瘤细胞系 B16F10 显示出有效的细胞毒性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Reticulol 相关抗体:
体内研究
(In Vivo)

Reticulol (10 mg/kg，50 mg/kg；静脉注射；肿瘤植入后第 3 天和第 5 天) 抑制 B16F10 黑色素瘤小鼠的肿瘤生长，并显示肺转移阻断作用[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Pathogen-free female C57BL/6J mice[1]
Dosage: 10 mg/kg, 50 mg/kg
Administration: IV via the tail vein; day 3 and day 5 after tumor implanted
Result: Inhibited tumor growth.
分子量

222.19

Formula

C11H10O5
CAS 号
结构分类
初始来源

Streptoverticillium album
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Reticulol 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Reticulol26246-41-3K 251-1Phosphodiesterase (PDE)adenosine 3'5'-monophosphate phosphodiesterasemurine melanoma cellshuman lung tumor cellsInhibitorinhibitorinhibit

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