2. Anti-infection Apoptosis
  3. Antibiotic Fungal Apoptosis
  4. Reveromycin A

Reveromycin A  (Synonyms: 雷弗霉素A)

目录号: HY-129337 纯度: 99.00%
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Reveromycin A 是一种从链霉菌属中分离出来的苯甲醌类抗生素 (antibiotic)，是选择性的真核细胞中蛋白质合成 (protein synthesis) 抑制剂。Reveromycin A 通过诱导破骨细胞的凋亡 (apoptosis) 来抑制骨吸收。Reveromycin A 对肿瘤细胞系具有抗增殖活性，并具有抗真菌 (antifungal) 活性。

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Reveromycin A Chemical Structure

Reveromycin A Chemical Structure

CAS No. : 134615-37-5

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1 mg ￥18200
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Reveromycin A 相关抗体

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Aminoglycoside Glycopeptide Lipopeptide Macrolide Oxazolidinone Quinolone Tetracycline β-lactam

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Reveromycin A, a benzoquinoid antibiotic isolated from the genus Streptomyces, is a selective inhibitor of protein synthesis in eukaryotic cells. Reveromycin A inhibits bone resorption by inducing apoptosis specifically in osteoclasts. Reveromycin A has antiproliferative activity against tumor cell lines and antifungal activity[1][2].

体外研究
(In Vitro)

Reveromycin A inhibits protein synthesis in osteoclasts (OCs) by selectively blocking enzymatic activity of isoleucyl-tRNA synthetase[2].
Reveromycin A (0.3-30 μM; for 24 h) induces apoptosis in OCs through inhibition of protein synthesis[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Reveromycin A 相关抗体:
体内研究
(In Vivo)

Reveromycin A (20 mg/kg; twice daily; i.v.; for 3 days) significantly decreases numbers of OCs without affecting numbers of osteoblasts in normal 4-week-old male Sprague-Dawley rats[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

660.79

Formula

C36H52O11
CAS 号
性状

固体

颜色

White to off-white

中文名称

雷弗霉素A
结构分类
初始来源

Actinomycete
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
纯度 & 产品资料

纯度: ≥99.0%

COA (285 KB)

产品使用指南 (1538 KB)
参考文献

Reveromycin A 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Reveromycin A134615-37-5雷弗霉素AAntibioticFungalApoptosisproteinsynthesiseukaryoticboneresorptionosteoclastsantiproliferativeisoleucyl-tRNAInhibitorinhibitorinhibit

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