Rilonacept  (Synonyms: Arcalyst; IL 1 Trap; Interleukin 1 Trap)

Rilonacept (Arcalyst), a dimeric fusion protein, is a interleukin 1 inhibitor. Rilonacept consists of the ligand-binding domains of the extracellular portions of the IL-1R components linked to the Fc portion of human IgG1. Rilonacept can be used for the research of cryopyrin-associated periodic syndromes^[1].

Human

Rilonacept blocks IL-1α signaling by acting as a soluble decoy receptor that binds IL-1β and prevents its interaction with cell–surface receptors, thereby reducing the inflammatory process^[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

501081-76-1

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  [IL1RAP (interleukin-1 receptor accessory protein)-IL1R1 (type 1 interleukin-1 receptor, interleukin 1 receptor, type I)]2-IGHG1 Fc (Fragment constant)

• [1]. Kapur S, et, al. Rilonacept (arcalyst), an interleukin-1 trap for the treatment of cryopyrin-associated periodic syndromes. P T. 2009 Mar;34(3):138-41.  [Content Brief]