2. Epigenetics
  3. Histone Methyltransferase
  4. RK-0133114

RK-0133114 是 G9a 抑制剂，也是 RK-701 (HY-152775) 的 R-对映体。RK-0133114 抑制 G9a 的 IC50 值为 3.7 μM。RK-0133114 可用于镰状细胞病 (SCD) 的研究。

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RK-0133114 Chemical Structure

RK-0133114 Chemical Structure

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Other Forms of RK-0133114:

RK-0133114 相关抗体

Top Publications Citing Use of Products

查看 Histone Methyltransferase 亚型特异性产品:

查看所有亚型
EZH1 EZH2 DOT1L SMYD2 SMYD3 SUV39H2/KMT1B EHMT2/G9a/KMT1C EHMT1/GLP/KMT1D SETDB1/KMT2G SETD2/KMT3A NSD2/MMSET/WHSC1 SETD7/KMT7 SETD8/KMT5A PRMT1 PRMT3 PRMT4 PRMT5 PRMT6 PRMT7 PRMT8

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

RK-0133114 is a G9a inhibitor and a R-enantiomer of RK-701 (HY-152775). RK-0133114 inhibits G9a with an IC50 value of 3.7 μM. RK-0133114 can be used for the research of sickle cell disease (SCD)[1].

体外研究
(In Vitro)

RK-0133114 对人脐血来源的 erythroid progenitor 2 (HUDEP-2) 细胞中 H3K9me2 的水平无影响，并且无法增加 HUDEP-2 细胞中 fetal globins (HbF)[1].
RK-0133114 (0.1 nM-100 μM) 抑制 G9a 的 IC50 值为 3.7 μM[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

RK-0133114 相关抗体:
分子量

446.54

Formula

C26H30N4O3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

RK-0133114 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

RK-0133114RK0133114RK 0133114Histone MethyltransferaseR-enantiomerSCDH3K9me2HUDEP-2Inhibitorinhibitorinhibit

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产品名称：
RK-0133114
目录号：
HY-152775A
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