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  4. RL71

RL71 是一种姜黄素类抗癌剂，对多种 ER 阴性乳腺癌细胞表现出强烈的细胞毒性。RL71（1 μM）能诱导细胞周期在 G2/M 期停滞，并诱导 SKBr3 细胞中凋亡。RL7 还降低 HER2/neu 的磷酸化并增加了 p27。RL71 还显著降低了 Akt 的磷酸化并短暂增加了应激激酶 JNK1/2 和 p38 MAPK。此外，RL71 在体外表现出抗血管生成潜力，抑制 HUVEC 细胞的迁移以及这些细胞形成管状网络的能力。

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RL71 Chemical Structure

RL71 Chemical Structure

CAS No. : 1195795-93-7

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5 mg ￥750
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10 mg ￥1200
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25 mg ￥2400
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50 mg ￥3800
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100 mg ￥5400
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Customer Review

RL71 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

RL71 is a curcuminoid anticancer agent that exhibits potent cytotoxicity against a variety of ER-negative breast cancer cells. RL71 (1 μM) induces cell cycle arrest in the G2/M phase and induces apoptosis in SKBr3 cells. RL7 also decreases HER2/neu phosphorylation and increases p27. RL71 also significantly reduced the phosphorylation of Akt and transiently increased the stress kinases JNK1/2 and p38 MAPK. Furthermore, RL71 exhibited anti-angiogenic potential in vitro, inhibiting the migration of HUVEC cells and the ability of these cells to form tubular networks[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
A549 IC50
0.39 μM
Compound: 574
Antiproliferative activity against human A549 cells assessed as cell viability by WST-1 assay
Antiproliferative activity against human A549 cells assessed as cell viability by WST-1 assay
[PMID: 32172081]
A549 IC50
1.7 μM
Compound: 5B
Cytotoxicity against human A549 cells assessed as reduction in cell viability after 72 hrs by MTT assay
Cytotoxicity against human A549 cells assessed as reduction in cell viability after 72 hrs by MTT assay
[PMID: 29655083]
L02 IC50
26.4 μM
Compound: 5B
Cytotoxicity against human HL7702 cells assessed as reduction in cell viability after 72 hrs by MTT assay
Cytotoxicity against human HL7702 cells assessed as reduction in cell viability after 72 hrs by MTT assay
[PMID: 29655083]
MDA-MB-231 EC50
0.3 μM
Compound: B10
Cytotoxicity against human MDA-MB-231 cells after 72 hrs by SRB assay
Cytotoxicity against human MDA-MB-231 cells after 72 hrs by SRB assay
[PMID: 20728364]
MDA-MB-231 IC50
0.39 μM
Compound: 574
Antiproliferative activity against human MDA-MB-231 cells assessed as cell viability by WST-1 assay
Antiproliferative activity against human MDA-MB-231 cells assessed as cell viability by WST-1 assay
[PMID: 32172081]
MDA-MB-468 EC50
0.3 μM
Compound: B10
Cytotoxicity against human MDA-MB-468 cells after 72 hrs by SRB assay
Cytotoxicity against human MDA-MB-468 cells after 72 hrs by SRB assay
[PMID: 20728364]
MDA-MB-468 IC50
0.39 μM
Compound: 574
Antiproliferative activity against human MDA-MB-468 cells assessed as cell viability by WST-1 assay
Antiproliferative activity against human MDA-MB-468 cells assessed as cell viability by WST-1 assay
[PMID: 32172081]
MG-63 IC50
0.39 μM
Compound: 574
Antiproliferative activity against human MG-63 cells assessed as cell viability by WST-1 assay
Antiproliferative activity against human MG-63 cells assessed as cell viability by WST-1 assay
[PMID: 32172081]
MV4-11 IC50
0.39 μM
Compound: 574
Antiproliferative activity against human MV4-11 cells assessed as cell viability by WST-1 assay
Antiproliferative activity against human MV4-11 cells assessed as cell viability by WST-1 assay
[PMID: 32172081]
NCI-H1650 IC50
1.5 μM
Compound: 5B
Cytotoxicity against human NCI-H1650 cells assessed as reduction in cell viability after 72 hrs by MTT assay
Cytotoxicity against human NCI-H1650 cells assessed as reduction in cell viability after 72 hrs by MTT assay
[PMID: 29655083]
NCI-H1975 IC50
1 μM
Compound: 5B
Cytotoxicity against human NCI-H1975 cells assessed as reduction in cell viability after 72 hrs by MTT assay
Cytotoxicity against human NCI-H1975 cells assessed as reduction in cell viability after 72 hrs by MTT assay
[PMID: 29655083]
NCI-H23 IC50
0.39 μM
Compound: 574
Antiproliferative activity against human NCI-H23 cells assessed as cell viability by WST-1 assay
Antiproliferative activity against human NCI-H23 cells assessed as cell viability by WST-1 assay
[PMID: 32172081]
NCI-H460 IC50
1 μM
Compound: 5B
Cytotoxicity against human H460 cells assessed as reduction in cell viability after 72 hrs by MTT assay
Cytotoxicity against human H460 cells assessed as reduction in cell viability after 72 hrs by MTT assay
[PMID: 29655083]
SK-BR-3 IC50
0.4 μM
Compound: B10
Cytotoxicity against human SKBR3 cells after 72 hrs by SRB assay
Cytotoxicity against human SKBR3 cells after 72 hrs by SRB assay
[PMID: 20728364]
分子量

469.53

Formula

C26H31NO7
CAS 号
性状

固体

颜色

Light yellow to yellow

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
细胞实验： 

DMSO 中的溶解度 : 100 mg/mL (212.98 mM; 超声助溶 (<60°C); 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.1298 mL 10.6489 mL 21.2979 mL
5 mM 0.4260 mL 2.1298 mL 4.2596 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

RL71 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.1298 mL 10.6489 mL 21.2979 mL 53.2447 mL
5 mM 0.4260 mL 2.1298 mL 4.2596 mL 10.6489 mL
10 mM 0.2130 mL 1.0649 mL 2.1298 mL 5.3245 mL
15 mM 0.1420 mL 0.7099 mL 1.4199 mL 3.5496 mL
20 mM 0.1065 mL 0.5324 mL 1.0649 mL 2.6622 mL
25 mM 0.0852 mL 0.4260 mL 0.8519 mL 2.1298 mL
30 mM 0.0710 mL 0.3550 mL 0.7099 mL 1.7748 mL
40 mM 0.0532 mL 0.2662 mL 0.5324 mL 1.3311 mL
50 mM 0.0426 mL 0.2130 mL 0.4260 mL 1.0649 mL
60 mM 0.0355 mL 0.1775 mL 0.3550 mL 0.8874 mL
80 mM 0.0266 mL 0.1331 mL 0.2662 mL 0.6656 mL
100 mM 0.0213 mL 0.1065 mL 0.2130 mL 0.5324 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

RL711195795-93-7RL 71RL-71OthersInhibitorinhibitorinhibit

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