2. Cell Cycle/DNA Damage Stem Cell/Wnt Cytoskeleton TGF-beta/Smad
  3. ROCK
  4. ROCK-IN-9

ROCK-IN-9 (Compound T345) 是一种 ROCK 抑制剂。ROCK-IN-9 在 HepG2 细胞中显示出细胞毒性，IC50 为 40.8 μM。ROCK-IN-9 在小鼠体内具有良好的药代动力学特性，并在较低剂量下表现出较高的体内暴露量和口服生物利用度。

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ROCK-IN-9 Chemical Structure

ROCK-IN-9 Chemical Structure

CAS No. : 2643334-76-1

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ROCK-IN-9 相关抗体

Top Publications Citing Use of Products

查看 ROCK 亚型特异性产品:

查看所有亚型
ROCK ROCK1 ROCK2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

ROCK-IN-9 (Compound T345) is a ROCK inhibitor. ROCK-IN-9 shows cytotoxicity in HepG2 cell, with an IC50 of 40.8 μM. ROCK-IN-9 has good pharmacokinetic properties in mice, and shows high in vivo exposure and oral bioavailability at lower doses[1].

分子量

381.40

Formula

C20H20FN5O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

ROCK-IN-9 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ROCK-IN-92643334-76-1ROCKRho-associated protein kinaseRho-associated kinaseRho-kinaseROKcytotoxicityHepG2ROCK inhibitorInhibitorinhibitorinhibit

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