2. Inhibitory Antibodies
  3. Romosozumab

Romosozumab  (Synonyms: 罗莫单抗)

目录号: HY-P9982 纯度: 99.11%
COA 技术支持

Romosozumab 是人源化抗硬化蛋白单克隆抗体，可通过抑制骨吸收促进骨形成和抑制骨硬化素。Romosozumab 可用于骨质疏松的研究。

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CAS No. : 909395-70-6

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1 mg ￥2800
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5 mg ￥7000
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Romosozumab 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Romosozumab is a humanized monoclonal anti-sclerostin antibody, it promotes bone formation and inhibits bone resorption by inhibiting sclerostin. Romosozumab can be used for the research of osteoporosis[1][2].

同型

Human IgG2 kappa
推荐同型对照抗体
种属

Humanized
体内研究
(In Vivo)

Romosozumab (30 mg/kg; s.c. twice a week for 10 weeks) converts trabecular rods into trabecular plates in cynomolgus monkeys[1].
Romosozumab (3 and 30 mg/kg; s.c. once a week for 6 or 12 months) improves bone mass, architecture, and bone strength, and maintains bone quality at the same time in mature cynomolgus monkeys with 4 months post-ovariectomy[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male cynomolgus monkeys[1]
Dosage: 30 mg/kg
Administration: Subcutaneous injection; 30 mg/kg twice a week for 10 weeks
Result: Increased bone formation and plate-like trabecular morphology, and improved mechanical performance.
Clinical Trial
CAS 号
性状

液体

颜色

Colorless to light yellow

中文名称

罗莫单抗
运输条件

Shipping with dry ice.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG2 kappa
Biological Activity
  • Immobilized SOST Protein, Human can bind Romosozumab. The EC50 for this effect is 12.46 ng/mL.
纯度 & 产品资料

纯度: 99.11%

COA (264 KB)

抗体抑制剂使用指南 (1152 KB)
参考文献

Romosozumab 相关分类

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  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Romosozumab909395-70-6罗莫单抗Othersmonoclonalbone formationbone resorptionsclerostinosteoporosisInhibitorinhibitorinhibit

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