2. Metabolic Enzyme/Protease
  3. Phosphodiesterase (PDE)
  4. RS14203

RS14203 是一种口服活性的 IV 型环核苷酸磷酸二酯酶 (PDE IV) 抑制剂，可以诱导呕吐。

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RS14203 Chemical Structure

RS14203 Chemical Structure

CAS No. : 159925-31-2

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RS14203 相关抗体

Top Publications Citing Use of Products

查看 Phosphodiesterase (PDE) 亚型特异性产品:

查看所有亚型
PDE1 PDE2 PDE3 PDE4 PDE5 PDE6 PDE7 PDE9 PDE10 PDE11 PDE12 PDE8 Autotaxin

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

RS14203 is an orally active type IV cyclic nucleotide phosphodiesterase (PDE IV) inhibitor which can induce emesis[1].

IC50 & Target

PDE4

 

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
Sf9 IC50
5 nM
Compound: 11; CHEMBL127944
Inhibition of recombinant human PDE4D7 catalytic domain expressed in baculovirus infected sf9 cells using cAMP as substrate
Inhibition of recombinant human PDE4D7 catalytic domain expressed in baculovirus infected sf9 cells using cAMP as substrate
[PMID: 26908025]
Sf9 IC50
70 pM
Compound: 11; CHEMBL127944
Inhibition of recombinant human PDE4B catalytic domain expressed in baculovirus infected sf9 cells using cAMP as substrate
Inhibition of recombinant human PDE4B catalytic domain expressed in baculovirus infected sf9 cells using cAMP as substrate
[PMID: 26908025]
分子量

341.36

Formula

C21H15N3O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

RS14203 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

RS14203159925-31-2PMNPQRS 14203RS-14203Phosphodiesterase (PDE)PDE IV inhibitoremesisferretInhibitorinhibitorinhibit

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产品名称：
RS14203
目录号：
HY-69317
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