2. Membrane Transporter/Ion Channel GPCR/G Protein Neuronal Signaling
  3. nAChR 5-HT Receptor
  4. (S)-PNU-282987 hydrochloride

(S)-PNU-282987 hydrochloride 是 PNU-282987 (HY-12560) 的一种异构体。PNU-282987 (free base) 是一种有效的 α7 烟碱乙酰胆碱受体 (nAChR) 激动剂，EC50 为 154 nM。 PNU-282987 (free base) 也是 5-HT3 受体的功能性拮抗剂，IC50 为 4541 nM。PNU-282987 (free base) 可用于中枢和外周神经系统的研究。

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(S)-PNU-282987 hydrochloride Chemical Structure

(S)-PNU-282987 hydrochloride Chemical Structure

CAS No. : 128311-08-0

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(S)-PNU-282987 hydrochloride 的其他形式现货产品:

Other Forms of (S)-PNU-282987 hydrochloride:

(S)-PNU-282987 hydrochloride 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

(S)-PNU-282987 hydrochloride is an isoform of PNU-282987 (HY-12560). PNU-282987 (free base) is a potent α7 nicotinic acetylcholine receptor (nAChR) agonist with an EC50 of 154 nM. PNU-282987 (free base) is also a functional antagonist of the 5-HT3 receptor with an IC50 of 4541 nM. PNU-282987 (free base) can be used for the research of central and peripheral nervous systems[1].

体外研究
(In Vitro)

PNU-282987 (free base) (Compound C7) 可取代大鼠脑匀浆中的 R7 选择性拮抗剂甲基乌头碱 (MLA)，Ki 为 27 nM[1]。< br/> PNU-282987 具有 α7 nAChR 激动剂活性，EC50 为 154 nM[1]。
PNU-282987 还对 5-HT3 受体具有抑制作用，IC50 值为 4541 nM[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

(S)-PNU-282987 hydrochloride 相关抗体:
体内研究
(In Vivo)

PNU-282987 (free base) (Compound C7) (静脉注射；1, 3 mg/kg) 可逆转门控缺陷[1]。
PNU-282987 (30 μM) 以浓度依赖性和 MLA 可阻断的方式在大鼠海马神经元中激发电流[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

301.21

Formula

C14H18Cl2N2O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

(S)-PNU-282987 hydrochloride 相关分类

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  • Do most proteins show cross-species activity?

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Keywords:

(S)-PNU-282987128311-08-0nAChR5-HT ReceptorNicotinic acetylcholine receptorsSerotonin Receptor5-hydroxytryptamine ReceptorInhibitorinhibitorinhibit

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目录号：
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