2. Epigenetics TGF-beta/Smad
  3. PKC
  4. (S)-Ro 32-0432 free base

(S)-Ro 32-0432 free base 是一种有效的、选择性的 ATP 竞争性和具有口服活性的 PKC 抑制剂，对 PKCα、PKCβI、PKCβII、PKCγ 和 PKCε 的 IC50 值分别为 9.3 nM，28 nM，30 nM，36.5 nM 和 108.3 nM。(S)-Ro 32-0432 free base 也是一种选择性 GRK5 的抑制剂。(S)-Ro 32-0432 free base 可防止 T 细胞活化，并可用于慢性炎症和自身免疫性疾病的研究。

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(S)-Ro 32-0432 free base Chemical Structure

(S)-Ro 32-0432 free base Chemical Structure

CAS No. : 151342-35-7

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(S)-Ro 32-0432 free base 相关抗体

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PKC PKCα PKCβ PKCγ PKCδ PKCε PKCη PKCζ PKCθ PKCμ PKCι

  • 生物活性

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生物活性

(S)-Ro 32-0432 free base is a potent, selective, ATP-competitive and orally active PKC inhibitor. The IC50 values of (S)-Ro 32-0432 free base for PKCα, PKCβI, PKCβII, PKCγ and PKCε are 9.3 nM, 28 nM, 30 nM, 36.5 nM and 108.3 nM, respectively. (S)-Ro 32-0432 free base is also a selective G protein-coupled receptor kinase 5 (GRK5) inhibitor. (S)-Ro 32-0432 free base prevents T-cell activation and has the potential for chronic inflammatory and autoimmune diseases research[1][2].

分子量

452.55

Formula

C28H28N4O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

(S)-Ro 32-0432 free base 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(S)-Ro 32-0432151342-35-7PKCProtein kinase CAnti-inflammatoryT-cellsATP-competitivePKCαIL-2anti-proliferationsystemicGRK5Inhibitorinhibitorinhibit

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