Sabcomeline (Synonyms: SB-202026; Memric)

目录号: HY-106432: FAQs
Data Sheet 产品使用指南

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Sabcomeline (SB-202026) 是一种有效的功能性选择性 M1 毒蕈碱受体受体 ( muscarinic M1 receptor) 部分激动剂，可以改善认知功能。Sabcomeline 可用于阿尔茨海默症的研究。

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Sabcomeline Chemical Structure

CAS No. : 159912-53-5

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Sabcomeline 的其他形式现货产品:

Sabcomeline hydrochloride

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mAChR1 mAChR2 mAChR3 mAChR4 mAChR5

生物活性
纯度 & 产品资料
参考文献

生物活性

Sabcomeline (SB-202026) is a potent and functionally selective muscarinic M1 receptor partial agonist that improve cognition. Sabcomeline can be used for Alzheimer's disease research^[1]^[2].

IC₅₀ & Target

Muscarinic M1 receptor^[1]^[2]

细胞效力
(Cellular Effect)

Cell Line	Type	Value	Description	References
CHO	EC₅₀	117 nM Compound: Sabcomeline	Agonist activity at human muscarinic M3 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay Agonist activity at human muscarinic M3 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	[PMID: 26299349]
CHO	EC₅₀	123 nM Compound: Sabcomeline	Agonist activity at human muscarinic M5 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay Agonist activity at human muscarinic M5 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	[PMID: 26299349]
CHO	EC₅₀	214 nM Compound: Sabcomeline	Agonist activity at human muscarinic M4 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay Agonist activity at human muscarinic M4 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	[PMID: 26299349]
CHO	EC₅₀	5.7 nM Compound: Sabcomeline	Partial agonist activity at human M4 receptor co-expressed with Galpha16 in CHO cells assessed as calcium mobilization after 60 mins by FLIPR assay Partial agonist activity at human M4 receptor co-expressed with Galpha16 in CHO cells assessed as calcium mobilization after 60 mins by FLIPR assay	[PMID: 24900656]
CHO	EC₅₀	62.1 nM Compound: Sabcomeline	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	[PMID: 26299349]
CHO	EC₅₀	63.6 nM Compound: Sabcomeline	Agonist activity at human muscarinic M1 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay Agonist activity at human muscarinic M1 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	[PMID: 26299349]

分子量

193.25

Formula

C₁₀H₁₅N₃O

CAS 号

159912-53-5

中文名称

沙可美林

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料

产品使用指南 (1538 KB)

参考文献

[1]. Hosoi R, et al. Effect of sabcomeline on muscarinic and dopamine receptor binding in intact mouse brain. Ann Nucl Med. 2003;17(2):123-130. [Content Brief]

[2]. Hatcher JP, et al. Sabcomeline (SB-202026), a functionally selective M1 receptor partial agonist, reverses delay-induced deficits in the T-maze. Psychopharmacology (Berl). 1998;138(3-4):275-282. [Content Brief]

Sabcomeline 相关分类

Neurological Disease

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稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量		浓度		体积		分子量 *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

浓度 _(start)	×	体积 _(start)	=	浓度 _(final)	×	体积 _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Sabcomeline159912-53-5SB-202026 Memric沙可美林SB202026SB 202026mAChRMuscarinic acetylcholine receptorAlzheimer's diseaseInhibitorinhibitorinhibit

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

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营业执照（三证合一）

Sabcomeline (Synonyms: SB-202026; Memric)

Customer Review

Other Forms of Sabcomeline:

Sabcomeline 相关产品

•同靶点产品:

•同靶点蛋白产品:

查看 mAChR 亚型特异性产品:

生物活性

纯度 & 产品资料

参考文献

Sabcomeline 相关分类

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Sabcomeline (Synonyms: SB-202026; Memric)

Customer Review

Other Forms of Sabcomeline:

Sabcomeline 相关抗体

Sabcomeline 相关产品

•同靶点产品:

•同靶点蛋白产品:

查看 mAChR 亚型特异性产品:

生物活性

纯度 & 产品资料

参考文献

Sabcomeline 相关分类

摩尔计算器

稀释计算器

The molarity calculator equation

The dilution calculator equation

Keywords:

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