2. MAPK/ERK Pathway Protein Tyrosine Kinase/RTK Epigenetics TGF-beta/Smad
  3. p38 MAPK Src PKC
  4. SB 220025 (tri(hydrochloride))

SB 220025 (tri(hydrochloride)) 

目录号: HY-112291A
产品使用指南

摩尔计算器

SB 220025 trihydrochloride 是一种可逆的、口服有效的、具有细胞渗透性、ATP 竞争性和选择性的人 p38 MAPK 抑制剂 (IC50 = 60 nM)。SB 220025 trihydrochloride 还能抑 p56Lck 和 PKC，其 IC50 值分别为 3.5 和 2.89 μM。SB 220025 trihydrochloride 能抑制响应球型脂联素 (gAd) 的 IL-8 基因的表达，并减少炎症细胞因子的产生并抑制血管生成。SB 220025 trihydrochloride 在慢性炎症疾病模型中有效地阻止关节炎的进展，可用于炎症的研究。

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SB 220025 (tri(hydrochloride)) Chemical Structure

SB 220025 (tri(hydrochloride)) Chemical Structure

CAS No. : 197446-75-6

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SB 220025 (tri(hydrochloride)) 的其他形式现货产品:

Other Forms of SB 220025 (tri(hydrochloride)):

SB 220025 (tri(hydrochloride)) 相关抗体

Top Publications Citing Use of Products

查看 p38 MAPK 亚型特异性产品:

查看所有亚型
p38 MAPK p38α p38β MAPK13 p38δ p38γ

查看 Src 亚型特异性产品:

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Lck Fyn Blk

查看 PKC 亚型特异性产品:

查看所有亚型
PKC PKCα PKCβ PKCγ PKCδ PKCε PKCη PKCζ PKCθ PKCμ PKCι

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

SB 220025 trihydrochloride is a reversible, orally active, cell-permeable, ATP-competitive and selective human p38 MAPK inhibitor (IC50 = 60 nM). SB 220025 trihydrochloride also inhibits p56Lck and PKC with IC50 values of 3.5 and 2.89 μM, respectively. SB 220025 trihydrochloride inhibits the expression of IL-8 gene in response to globular adiponectin (gAd), reduces inflammatory cytokine production and inhibits angiogenesis. SB 220025 trihydrochloride effectively prevents the progression of arthritis in a chronic inflammatory disease model and can be used in the study of inflammation[1][2].

分子量

447.76

Formula

C18H22Cl3FN6
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

SB 220025 (tri(hydrochloride)) 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SB 220025 (tri(hydrochloride))197446-75-6p38 MAPKSrcPKCProtein kinase CHUVEC cellsinflammationgAdIL-8p56-LckarthritisInhibitorinhibitorinhibit

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