2. Membrane Transporter/Ion Channel
  3. Apical Sodium-Dependent Bile Acid Transporter
  4. SC-435

SC-435 是一种口服有效的顶端钠依赖性胆汁酸转运蛋白 (ASBT) 抑制剂，通过抑制肠道 ASBT 可有效清除血液中的神经毒性胆汁酸和氨，从而减轻肝功能衰竭引起的肝和脑损伤。SC-435 可以改变肝胆固醇代谢以及降低血浆胆固醇浓度 。

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SC-435 Chemical Structure

SC-435 Chemical Structure

CAS No. : 289037-67-8

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1 mg ￥3500
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Customer Review

SC-435 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

SC-435 is an orally effective apical sodium codependent bile acid transporter (ASBT) inhibitor. SC-435 effectively removes neurotoxic bile acids and ammonia from the blood by inhibiting intestinal ASBT, thereby alleviating liver and brain damage caused by liver failure. SC-435 can alter hepatic cholesterol metabolism and lower plasma low-density lipoprotein-cholesterol concentrations[1] [2] [3].

IC50 & Target

Bile acid transporter[1]
体内研究
(In Vivo)

SC-435 (10 μg/1 g; 口服；5-16 周) 在 Streptozotocin (HY-13753) 诱导的小鼠慢性肝病和 Azoxymethane (HY-111375) 诱导的小鼠急性肝衰竭模型中减轻肝功能衰竭引起的肝和脑损伤[2]。
SC-435（0.03-0.1 g/100 g; 口服; 12 周) 单独或与 Simvastatin (HY-17502) 联合使用可以在豚鼠内源性高胆固醇血症模型中通过改变肝脏胆固醇稳态和血管内脂蛋白加工来降低低密度脂蛋白胆固醇浓度[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Streptozotocin (HY-13753) or Azoxymethane (HY-111375) treated male C57BL/6J mice (25-30 g)[2]
Dosage: 10 μg/1 g, 16 weeks;
10 μg/1 g, 5 days
Administration: Oral administration (p.o.)
Result: Reduced bile acids and ammonia concentrations in the blood and brain.
Alleviated liver and brain damages.
Animal Model: Hartley guinea pigs (250-300 g) with endogenous hypercholesterolemia[3]
Dosage: 0.1 g/100 g SC-435;
0.03 g/100 g SC-435 combined with 0.05 g/100 g Simvastatin (HY-17502)
Administration: Oral administration (p.o.); 12 weeks
Result: Compared to the control group, CETP activity was 34% and 56% lower with SC-435 and the combination of SC-435 and Simvastatin, respectively.
Compared to the control group, Cholesterol 7α-hydroxylase and HMG-CoA reductase activities were increased 2-fold with SC-435 and the combination of SC-435 and Simvastatin, respectively.
Compared to the control group, HMG-CoA reductase mRNA expression was increased 33% with SC-435.
分子量

722.01

Formula

C37H59N3O7S2
CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据
细胞实验： 

DMSO 中的溶解度 : ≥ 50 mg/mL (69.25 mM; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

* "≥" means soluble, but saturation unknown.

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.3850 mL 6.9251 mL 13.8502 mL
5 mM 0.2770 mL 1.3850 mL 2.7700 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

SC-435 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.3850 mL 6.9251 mL 13.8502 mL 34.6256 mL
5 mM 0.2770 mL 1.3850 mL 2.7700 mL 6.9251 mL
10 mM 0.1385 mL 0.6925 mL 1.3850 mL 3.4626 mL
15 mM 0.0923 mL 0.4617 mL 0.9233 mL 2.3084 mL
20 mM 0.0693 mL 0.3463 mL 0.6925 mL 1.7313 mL
25 mM 0.0554 mL 0.2770 mL 0.5540 mL 1.3850 mL
30 mM 0.0462 mL 0.2308 mL 0.4617 mL 1.1542 mL
40 mM 0.0346 mL 0.1731 mL 0.3463 mL 0.8656 mL
50 mM 0.0277 mL 0.1385 mL 0.2770 mL 0.6925 mL
60 mM 0.0231 mL 0.1154 mL 0.2308 mL 0.5771 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SC-435289037-67-8SC435SC 435Apical Sodium-Dependent Bile Acid TransporterASBTIleal Bile Acid TransporterIBATSLC10A2Bile acidBACholesterolLiver failure modelInhibitorinhibitorinhibit

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