2. Membrane Transporter/Ion Channel
  3. Na+/K+ ATPase
  4. SC4453

SC4453 是一种地高辛类似物，其 C17β 上的内酯环被吡嗪环取代。SC4453 在抑制（Na+ + K+）-ATP 酶方面略逊色于地高辛，但对钾离子显示出类似的敏感性。SC4453 对不同物种的心脏和脑组织的敏感性差异主要由其与受体的解离速率不同所致。这些观察结果确认了人类心脏对强心苷的高敏感性。

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SC4453 Chemical Structure

SC4453 Chemical Structure

CAS No. : 59712-21-9

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SC4453 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

SC4453 is a digoxin analogue in which the lactone ring at C17β is replaced by a pyrazine ring. SC4453 is slightly inferior to digoxin in inhibiting (Na+ + K+)-ATPase, but shows similar sensitivity to potassium ions. The differences in the sensitivity of SC4453 to heart and brain tissue from different species are mainly due to differences in its dissociation rate from the receptor. These observations confirm the high sensitivity of the human heart to cardiac glycosides.

分子量

822.98

Formula

C43H66O15
CAS 号
结构分类
初始来源

human heart
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

SC4453 相关分类

  • 摩尔计算器

  • 稀释计算器

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SC445359712-21-9SC 4453SC-4453Na+/K+ ATPaseSodium potassium pumpInhibitorinhibitorinhibit

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