Se-Aspirin (Synonyms: Selenium-acetylsalicylic acid)

目录号: HY-117429: FAQs
Data Sheet 产品使用指南

摩尔计算器

Se-Aspirin 是硒和 Aspirin (HY-14654) 的混合分子。Se-Aspirin 降低了癌细胞系，特别是结直肠癌细胞的活力。

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Se-Aspirin Chemical Structure

CAS No. : 1850293-95-6

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生物活性
纯度 & 产品资料
参考文献

生物活性

Se-Aspirin is a hybrid molecule of selenium and Aspirin (HY-14654). Se-Aspirin reduces the viability of cancer cell lines, particularly colorectal cancer cells^[1].

细胞效力
(Cellular Effect)

Cell Line	Type	Value	Description	References
DU-145	IC₅₀	2.9 μM Compound: 8	Antiproliferative activity against human DU145 cells assessed as reduction in cell viability after 72 hrs by MTT assay Antiproliferative activity against human DU145 cells assessed as reduction in cell viability after 72 hrs by MTT assay	[PMID: 26750401]
DU-145	IC₅₀	3.4 μM Compound: 8	Antiproliferative activity against human DU145 cells assessed as reduction in cell viability after 48 hrs by MTT assay Antiproliferative activity against human DU145 cells assessed as reduction in cell viability after 48 hrs by MTT assay	[PMID: 26750401]
DU-145	IC₅₀	8.2 μM Compound: 8	Antiproliferative activity against human DU145 cells assessed as reduction in cell viability after 24 hrs by MTT assay Antiproliferative activity against human DU145 cells assessed as reduction in cell viability after 24 hrs by MTT assay	[PMID: 26750401]
HCT-116	IC₅₀	16.2 μM Compound: 8	Antiproliferative activity against human HCT116 cells assessed as reduction in cell viability after 24 hrs by MTT assay Antiproliferative activity against human HCT116 cells assessed as reduction in cell viability after 24 hrs by MTT assay	[PMID: 26750401]
HCT-116	IC₅₀	2.1 μM Compound: 8	Antiproliferative activity against human HCT116 cells assessed as reduction in cell viability after 72 hrs by MTT assay Antiproliferative activity against human HCT116 cells assessed as reduction in cell viability after 72 hrs by MTT assay	[PMID: 26750401]
HCT-116	IC₅₀	2.5 μM Compound: 8	Antiproliferative activity against human HCT116 cells assessed as reduction in cell viability after 48 hrs by MTT assay Antiproliferative activity against human HCT116 cells assessed as reduction in cell viability after 48 hrs by MTT assay	[PMID: 26750401]
HepG2	IC₅₀	16 μM Compound: 8	Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability after 24 hrs by MTT assay Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability after 24 hrs by MTT assay	[PMID: 26750401]
HepG2	IC₅₀	4.3 μM Compound: 8	Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability after 72 hrs by MTT assay Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability after 72 hrs by MTT assay	[PMID: 26750401]
HepG2	IC₅₀	5 μM Compound: 8	Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability after 48 hrs by MTT assay Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability after 48 hrs by MTT assay	[PMID: 26750401]
HT-29	IC₅₀	2.1 μM Compound: 8	Antiproliferative activity against human HT-29 cells assessed as reduction in cell viability after 48 hrs by MTT assay Antiproliferative activity against human HT-29 cells assessed as reduction in cell viability after 48 hrs by MTT assay	[PMID: 26750401]
HT-29	IC₅₀	2.1 μM Compound: 8	Antiproliferative activity against human HT-29 cells assessed as reduction in cell viability after 72 hrs by MTT assay Antiproliferative activity against human HT-29 cells assessed as reduction in cell viability after 72 hrs by MTT assay	[PMID: 26750401]
HT-29	IC₅₀	3.4 μM Compound: 8	Antiproliferative activity against human HT-29 cells assessed as reduction in cell viability after 24 hrs by MTT assay Antiproliferative activity against human HT-29 cells assessed as reduction in cell viability after 24 hrs by MTT assay	[PMID: 26750401]
MDA-MB-231	IC₅₀	21.1 μM Compound: 8	Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability after 24 hrs by MTT assay Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability after 24 hrs by MTT assay	[PMID: 26750401]
MDA-MB-231	IC₅₀	5.5 μM Compound: 8	Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability after 48 hrs by MTT assay Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability after 48 hrs by MTT assay	[PMID: 26750401]
MDA-MB-231	IC₅₀	6 μM Compound: 8	Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability after 72 hrs by MTT assay Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability after 72 hrs by MTT assay	[PMID: 26750401]
NCI-H460	IC₅₀	> 50 μM Compound: 8	Antiproliferative activity against human NCI-H460 cells assessed as reduction in cell viability after 24 hrs by MTT assay Antiproliferative activity against human NCI-H460 cells assessed as reduction in cell viability after 24 hrs by MTT assay	[PMID: 26750401]
NCI-H460	IC₅₀	1.3 μM Compound: 8	Antiproliferative activity against human NCI-H460 cells assessed as reduction in cell viability after 72 hrs by MTT assay Antiproliferative activity against human NCI-H460 cells assessed as reduction in cell viability after 72 hrs by MTT assay	[PMID: 26750401]
NCI-H460	IC₅₀	2.4 μM Compound: 8	Antiproliferative activity against human NCI-H460 cells assessed as reduction in cell viability after 48 hrs by MTT assay Antiproliferative activity against human NCI-H460 cells assessed as reduction in cell viability after 48 hrs by MTT assay	[PMID: 26750401]
PANC-1	IC₅₀	12.1 μM Compound: 8	Antiproliferative activity against human PANC1 cells assessed as reduction in cell viability after 24 hrs by MTT assay Antiproliferative activity against human PANC1 cells assessed as reduction in cell viability after 24 hrs by MTT assay	[PMID: 26750401]
PANC-1	IC₅₀	2.1 μM Compound: 8	Antiproliferative activity against human PANC1 cells assessed as reduction in cell viability after 48 hrs by MTT assay Antiproliferative activity against human PANC1 cells assessed as reduction in cell viability after 48 hrs by MTT assay	[PMID: 26750401]
PANC-1	IC₅₀	2.6 μM Compound: 8	Antiproliferative activity against human PANC1 cells assessed as reduction in cell viability after 72 hrs by MTT assay Antiproliferative activity against human PANC1 cells assessed as reduction in cell viability after 72 hrs by MTT assay	[PMID: 26750401]
RKO	IC₅₀	13.3 μM Compound: 8	Antiproliferative activity against human RKO cells assessed as reduction in cell viability after 24 hrs by MTT assay Antiproliferative activity against human RKO cells assessed as reduction in cell viability after 24 hrs by MTT assay	[PMID: 26750401]
RKO	IC₅₀	2.2 μM Compound: 8	Antiproliferative activity against human RKO cells assessed as reduction in cell viability after 48 hrs by MTT assay Antiproliferative activity against human RKO cells assessed as reduction in cell viability after 48 hrs by MTT assay	[PMID: 26750401]
RKO	IC₅₀	2.9 μM Compound: 8	Antiproliferative activity against human RKO cells assessed as reduction in cell viability after 72 hrs by MTT assay Antiproliferative activity against human RKO cells assessed as reduction in cell viability after 72 hrs by MTT assay	[PMID: 26750401]
SK-OV-3	IC₅₀	> 50 μM Compound: 8	Antiproliferative activity against human SKOV3 cells assessed as reduction in cell viability after 24 hrs by MTT assay Antiproliferative activity against human SKOV3 cells assessed as reduction in cell viability after 24 hrs by MTT assay	[PMID: 26750401]
SK-OV-3	IC₅₀	4.4 μM Compound: 8	Antiproliferative activity against human SKOV3 cells assessed as reduction in cell viability after 72 hrs by MTT assay Antiproliferative activity against human SKOV3 cells assessed as reduction in cell viability after 72 hrs by MTT assay	[PMID: 26750401]
SK-OV-3	IC₅₀	5.3 μM Compound: 8	Antiproliferative activity against human SKOV3 cells assessed as reduction in cell viability after 48 hrs by MTT assay Antiproliferative activity against human SKOV3 cells assessed as reduction in cell viability after 48 hrs by MTT assay	[PMID: 26750401]
UACC-903	IC₅₀	2.9 μM Compound: 8	Antiproliferative activity against human UACC-903 cells assessed as reduction in cell viability after 72 hrs by MTT assay Antiproliferative activity against human UACC-903 cells assessed as reduction in cell viability after 72 hrs by MTT assay	[PMID: 26750401]
UACC-903	IC₅₀	24.3 μM Compound: 8	Antiproliferative activity against human UACC-903 cells assessed as reduction in cell viability after 24 hrs by MTT assay Antiproliferative activity against human UACC-903 cells assessed as reduction in cell viability after 24 hrs by MTT assay	[PMID: 26750401]
UACC-903	IC₅₀	4 μM Compound: 8	Antiproliferative activity against human UACC-903 cells assessed as reduction in cell viability after 48 hrs by MTT assay Antiproliferative activity against human UACC-903 cells assessed as reduction in cell viability after 48 hrs by MTT assay	[PMID: 26750401]

分子量

311.20

Formula

C₁₂H₁₂N₂O₃Se

CAS 号

1850293-95-6

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料

产品使用指南 (1538 KB)

参考文献

[1]. Plano D, et al. Design, Synthesis, and Biological Evaluation of Novel Selenium (Se-NSAID) Molecules as Anticancer Agents. J Med Chem. 2016 Mar 10;59(5):1946-59. [Content Brief]

Se-Aspirin 相关分类

Inflammation/Immunology

摩尔计算器
稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量		浓度		体积		分子量 *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

浓度 _(start)	×	体积 _(start)	=	浓度 _(final)	×	体积 _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Se-Aspirin1850293-95-6Selenium-acetylsalicylic acidNF-κBNuclear factor-κBNuclear factor-kappaBanti-inflammatoryCRCcolorectal cancerInhibitorinhibitorinhibit

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上海工商

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Se-Aspirin (Synonyms: Selenium-acetylsalicylic acid)

Se-Aspirin 相关产品

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Se-Aspirin (Synonyms: Selenium-acetylsalicylic acid)

Se-Aspirin 相关抗体

Se-Aspirin 相关产品

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•同靶点蛋白产品:

查看 NF-κB 亚型特异性产品:

生物活性

纯度 & 产品资料

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Se-Aspirin 相关分类

摩尔计算器

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